Search Results - "Ghoreschi, Kamran"

Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis by Ghoreschi, Kamran, Balato, Anna, Enerbäck, Charlotta, Sabat, Robert

“…Psoriasis is a chronic inflammatory disease characterised by sharply demarcated erythematous and scaly skin lesions accompanied by systemic manifestations…”
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Emerging Topical and Systemic JAK Inhibitors in Dermatology by Solimani, Farzan, Meier, Katharina, Ghoreschi, Kamran

“…Accumulating data on cellular and molecular pathways help to develop novel therapeutic strategies in skin inflammation and autoimmunity. Examples are psoriasis…”
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Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis by Herster, Franziska, Bittner, Zsofia, Archer, Nathan K., Dickhöfer, Sabine, Eisel, David, Eigenbrod, Tatjana, Knorpp, Thomas, Schneiderhan-Marra, Nicole, Löffler, Markus W., Kalbacher, Hubert, Vierbuchen, Tim, Heine, Holger, Miller, Lloyd S., Hartl, Dominik, Freund, Lukas, Schäkel, Knut, Heister, Martin, Ghoreschi, Kamran, Weber, Alexander N. R.

“…Psoriasis is an inflammatory skin disease with strong neutrophil (PMN) infiltration and high levels of the antimicrobial peptide, LL37. LL37 in complex with…”
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Janus kinases in immune cell signaling by Ghoreschi, Kamran, Laurence, Arian, O'Shea, John J

“…The Janus family kinases (Jaks), Jak1, Jak2, Jak3, and Tyk2, form one subgroup of the non-receptor protein tyrosine kinases. They are involved in cell growth,…”
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IL-17A in Psoriasis and Beyond: Cardiovascular and Metabolic Implications by von Stebut, Esther, Boehncke, Wolf-Henning, Ghoreschi, Kamran, Gori, Tommaso, Kaya, Ziya, Thaci, Diamant, Schäffler, Andreas

“…Interleukin 17A (IL-17A) is one of the currently known six members of the IL-17 cytokine family and is implicated in immune responses to infectious pathogens…”
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A review of the mechanisms of action of dimethylfumarate in the treatment of psoriasis by Brück, Jürgen, Dringen, Ralf, Amasuno, Adriana, Pau‐Charles, Ignasi, Ghoreschi, Kamran

“…Fumaric acid esters (FAEs) such as dimethylfumarate (DMF) are used for the treatment of adults with moderate‐to‐severe psoriasis. The mode of action of FAEs is…”
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Angiogenesis drives psoriasis pathogenesis by Heidenreich, Regina, Röcken, Martin, Ghoreschi, Kamran

“…Summary Psoriasis pathogenesis is closely associated with disease‐inducing Th1 and Th17 cells. Yet, several studies suggest that aberrant keratinocyte or…”
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Lichen planus – a clinical guide by Solimani, Farzan, Forchhammer, Stephan, Schloegl, Alexandra, Ghoreschi, Kamran, Meier, Katharina

“…Summary Lichen planus (LP) is a chronic lichenoid inflammatory disorder of the skin, mucosa and of the appendages. LP is classically characterized by the…”
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Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5 by Laurence, Arian, Yang, Xiang-Ping, Ghoreschi, Kamran, Steward-Tharp, Scott M, Rodriguez-Canales, Jaime, Zhu, Jinfang, Grainger, John R, Hirahara, Kiyoshi, Sun, Hong-Wei, Wei, Lai, Vahedi, Golnaz, Kanno, Yuka, O'Shea, John J

“…Loss of IL-2 signaling results in autoimmunity. Laurence and colleagues show that the IL-2–STAT5 axis counteracts STAT3 activation of Il17 to dampen IL-17…”
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An intensified dosing schedule of subcutaneous methotrexate in patients with moderate to severe plaque-type psoriasis (METOP): a 52 week, multicentre, randomised, double-blind, placebo-controlled, phase 3 trial by Warren, Richard B, MD, Mrowietz, Ulrich, Prof, von Kiedrowski, Ralph, MD, Niesmann, Johannes, MD, Wilsmann-Theis, Dagmar, MD, Ghoreschi, Kamran, MD, Zschocke, Ina, PhD, Falk, Thomas M, PhD, Blödorn-Schlicht, Norbert, MD, Reich, Kristian, Prof

“…Summary Background Methotrexate is one of the most commonly used systemic drugs for the treatment of moderate to severe psoriasis; however, high-quality…”
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Case Report: Apremilast for Therapy-Resistant Pemphigus Vulgaris by Meier, Katharina, Holstein, Julia, Solimani, Farzan, Waschke, Jens, Ghoreschi, Kamran

“…In pemphigus, elucidating the disease-causing immune mechanism and developing new therapeutic strategies are needed. In this context, the second messenger…”
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Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells by Ghoreschi, Kamran, Brück, Jürgen, Kellerer, Christina, Deng, Caishu, Peng, Haiyan, Rothfuss, Oliver, Hussain, Rehana Z, Gocke, Anne R, Respa, Annedore, Glocova, Ivana, Valtcheva, Nadejda, Alexander, Eva, Feil, Susanne, Feil, Robert, Schulze-Osthoff, Klaus, Rupec, Rudolf A, Lovett-Racke, Amy E, Dringen, Ralf, Racke, Michael K, Röcken, Martin

“…Fumarates improve multiple sclerosis (MS) and psoriasis, two diseases in which both IL-12 and IL-23 promote pathogenic T helper (Th) cell differentiation…”
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IL-4 abrogates TH17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells by Guenova, Emmanuella, Skabytska, Yuliya, Hoetzenecker, Wolfram, Weindl, Günther, Sauer, Karin, Tham, Manuela, Kim, Kyu-Won, Park, Ji-Hyeon, Seo, Ji Hae, Ignatova, Desislava, Cozzio, Antonio, Levesque, Mitchell P., Volz, Thomas, Köberle, Martin, Kaesler, Susanne, Thomas, Peter, Mailhammer, Reinhard, Ghoreschi, Kamran, Schäkel, Knut, Amarov, Boyko, Eichner, Martin, Schaller, Martin, Clark, Rachael A., Röcken, Martin, Biedermann, Tilo

“…Interleukin 4 (IL-4) can suppress delayed-type hypersensitivity reactions (DTHRs), including organ-specific autoimmune diseases in mice and humans. Despite the…”
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Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550) by Ghoreschi, Kamran, Jesson, Michael I, Li, Xiong, Lee, Jamie L, Ghosh, Sarbani, Alsup, Jason W, Warner, James D, Tanaka, Masao, Steward-Tharp, Scott M, Gadina, Massimo, Thomas, Craig J, Minnerly, John C, Storer, Chad E, LaBranche, Timothy P, Radi, Zaher A, Dowty, Martin E, Head, Richard D, Meyer, Debra M, Kishore, Nandini, O'Shea, John J

“…Inhibitors of the JAK family of nonreceptor tyrosine kinases have demonstrated clinical efficacy in rheumatoid arthritis and other inflammatory disorders;…”
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Signal transduction pathways and transcriptional regulation in Th17 cell differentiation by Hirahara, Kiyoshi, Ghoreschi, Kamran, Laurence, Arian, Yang, Xiang-Ping, Kanno, Yuka, O'Shea, John J

“…Abstract Over the last decade, our understanding of helper/effector T cell differentiation has changed dramatically. The discovery of interleukin…”
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Phytotherapeuthics Affecting the IL-1/IL-17/G-CSF Axis: A Complementary Treatment Option for Hidradenitis Suppurativa? by Witte, Katrin, Sabat, Robert, Witte-Händel, Ellen, Ghoreschi, Kamran, Wolk, Kerstin

“…Hidradenitis suppurativa (HS; also designated as acne inversa) is a chronic inflammatory disease characterized by painful skin lesions that occur in the…”
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Blood T Helper Memory Cells: A Tool for Studying Skin Inflammation in HS? by Witte, Katrin, Schneider-Burrus, Sylke, Salinas, Gabriela, Mössner, Rotraut, Ghoreschi, Kamran, Wolk, Kerstin, Sabat, Robert

“…Hidradenitis suppurativa (HS) is an inflammatory skin disease characterized by painful lesions on intertriginous body areas such as the axillary, inguinal, and…”
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Recent advances in understanding psoriasis [version 1; peer review: 2 approved] by Eberle, Franziska C, Brück, Jürgen, Holstein, Julia, Hirahara, Kiyoshi, Ghoreschi, Kamran

“…T helper (Th) cells producing interleukin (IL)-17, IL-22, and tumor necrosis factor (TNF) form the key T cell population driving psoriasis pathogenesis. They…”
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Editorial: JAK inhibition in autoimmune and inflammatory diseases by Telliez, Jean-Baptiste, Gadina, Massimo, Ghoreschi, Kamran, Silvennoinen, Olli, Spinelli, Francesca Romana

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Skin manifestations in spondyloarthritis by Meier, Katharina, Schloegl, Alexandra, Poddubnyy, Denis, Ghoreschi, Kamran

“…Spondyloarthritides (SpA) like psoriatic arthritis, axial spondyloarthritis/ankylosing spondylitis, reactive arthritis and inflammatory bowel disease…”
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