Search Results - "Ghonem, Nisanne S."

Fibrates and cholestasis by Ghonem, Nisanne S., Assis, David N., Boyer, James L.

“…Cholestasis, including primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), results from an impairment or disruption of bile production…”
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Treprostinil alleviates hepatic mitochondrial injury during rat renal ischemia-reperfusion injury by Hou, Joyce, Tolbert, Evelyn, Birkenbach, Mark, Ghonem, Nisanne S.

“…Renal ischemia-reperfusion injury (IRI) causes acute kidney injury as well as liver injury. Renal IRI depletes hepatic antioxidants, promotes hepatic…”
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Treprostinil reduces mitochondrial injury during rat renal ischemia-reperfusion injury by Ding, Meiwen, Tolbert, Evelyn, Birkenbach, Mark, Gohh, Reginald, Akhlaghi, Fatemeh, Ghonem, Nisanne S.

“…Renal ischemia-reperfusion injury (IRI) is a major factor contributing to acute kidney injury and it is associated with a high morbidity and mortality if…”
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Fibrates as adjuvant therapy for chronic cholestatic liver disease: Its time has come by Ghonem, Nisanne S., Boyer, James L.

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PPAR-Mediated Bile Acid Glucuronidation: Therapeutic Targets for the Treatment of Cholestatic Liver Diseases by Gallucci, Gina M, Hayes, Colleen M, Boyer, James L, Barbier, Olivier, Assis, David N, Ghonem, Nisanne S

“…Cholestatic liver diseases, including primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), result from an impairment of bile flow that…”
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Adjunct Fenofibrate Up‐regulates Bile Acid Glucuronidation and Improves Treatment Response For Patients With Cholestasis by Gallucci, Gina M., Trottier, Jocelyn, Hemme, Christopher, Assis, David N., Boyer, James L., Barbier, Olivier, Ghonem, Nisanne S.

“…Accumulation of cytotoxic bile acids (BAs) during cholestasis can result in liver failure. Glucuronidation, a phase II metabolism pathway responsible for BA…”
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Treprostinil, a prostacyclin analog, ameliorates renal ischemia-reperfusion injury: preclinical studies in a rat model of acute kidney injury by Ding, Meiwen, Tolbert, Evelyn, Birkenbach, Mark, Akhlaghi, Fatemeh, Gohh, Reginald, Ghonem, Nisanne S

“…Renal ischemia-reperfusion injury (IRI) is a major factor causing acute kidney injury (AKI). No pharmacological treatments for prevention or amelioration of…”
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Quantification of treprostinil concentration in rat and human using a novel validated and rapid liquid chromatography-tandem mass spectrometry method: Experimental and clinical applications in ischemia–reperfusion injury by Gallucci, Gina M., Agbabiaka, Mariam Oladepo, Ding, Meiwen, Gohh, Reginald, Ghonem, Nisanne S.

“…Overview of biological sample preparation and quantification of treprostinil by LC-MS/MS. [Display omitted] •Renal ischemia–reperfusion injury (IRI) is…”
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Peroxisome proliferator‐activated receptor α activates human multidrug resistance transporter 3/ATP‐binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion by Ghonem, Nisanne S., Ananthanarayanan, Meenakshisundaram, Soroka, Carol J., Boyer, James L.

“…Multidrug resistance transporter 3/ATP‐binding cassette protein subfamily B4 (MDR3/ABCB4) is a critical determinant of biliary phosphatidylcholine (PC)…”
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Fenofibrate Improves Liver Function and Reduces the Toxicity of the Bile Acid Pool in Patients With Primary Biliary Cholangitis and Primary Sclerosing Cholangitis Who Are Partial Responders to Ursodiol by Ghonem, Nisanne S., Auclair, Adam M., Hemme, Christopher L., Gallucci, Gina M., Rosa Rodriguez, Randolph, Boyer, James L., Assis, David N.

“…Cholestatic liver diseases result in the hepatic retention of bile acids, causing subsequent liver toxicity. Peroxisome proliferator‐activated receptor alpha…”
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Fenofibrate Downregulates NF-κB Signaling to Inhibit Pro-inflammatory Cytokine Secretion in Human THP-1 Macrophages and During Primary Biliary Cholangitis by Gallucci, Gina M., Alsuwayt, Bader, Auclair, Adam M., Boyer, James L., Assis, David N., Ghonem, Nisanne S.

“…Chronic liver diseases, e.g., cholestasis, are negatively impacted by inflammation, which further aggravates liver injury. Pharmacotherapy targeting the…”
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Treprostinil Improves Mitochondrial Dynamics and Reduces Oxidative Stress During Renal Ischemia-Reperfusion Injury in Rats: PO0346 by Ding, Meiwen, Tolbert, Evelyn, Birkenbach, Mark, Gohh, Reginald Y., Ghonem, Nisanne S.

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Treprostinil Inhibits Mitochondria-Mediated Apoptosis During Renal Ischemia-Reperfusion Injury in Rats: PO0169 by Ding, Meiwen, Tolbert, Evelyn, Birkenbach, Mark, Gohh, Reginald Y., Akhlaghi, Fatemeh, Ghonem, Nisanne S.

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On Fibrates and Cholestasis: A review by Ghonem, Nisanne S., Assis, David N., Boyer, James L.

“…Cholestasis, including primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), results from an impairment or disruption of bile production…”
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Peroxisome proliferator-activated receptor [alpha] activates human multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion by Ghonem, Nisanne S, Ananthanarayanan, Meenakshisundaram, Soroka, Carol J, Boyer, James L

“…Multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 (MDR3/ABCB4) is a critical determinant of biliary phosphatidylcholine (PC)…”
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Treprostinil for protection of liver grafts against ischemia and reperfusion injury during orthotopic liver transplantation - A translational study by Ghonem, Nisanne S

“…Orthotopic liver transplantation (OLT) is the only curative therapy for end-stage liver diseases. To overcome organ shortage, organs from extended criteria…”
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