Search Results - "Ghislin, Stephanie"

LFA-1 and ICAM-1 expression induced during melanoma-endothelial cell co-culture favors the transendothelial migration of melanoma cell lines in vitro by Ghislin, Stephanie, Obino, Dorian, Middendorp, Sandrine, Boggetto, Nicole, Alcaide-Loridan, Catherine, Deshayes, Frederique

“…Patients with metastatic melanoma have a poor median rate of survival. It is therefore necessary to increase our knowledge about melanoma cell dissemination…”
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Link between the EZH2 noncanonical pathway and microtubule organization center polarization during early T lymphopoiesis by Deshayes, Frederique, Fradet, Magali, Kaminski, Sandra, Viguier, Mireille, Frippiat, Jean-Pol, Ghislin, Stephanie

“…EZH2 plays an essential role at the β-selection checkpoint of T lymphopoiesis by regulating histone H3 lysine 27 trimethylation (H3K27me3) via its canonical…”
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PHF19 and Akt control the switch between proliferative and invasive states in melanoma by Ghislin, Stephanie, Deshayes, Frederique, Middendorp, Sandrine, Boggetto, Nicole, Alcaide-Loridan, Catherine

“…Melanoma tumor cells shift between proliferative and invasive states based on their plasticity and microenvironmental conditions. Our team has shown that…”
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Nanog and Oct4 overexpression increases motility and transmigration of melanoma cells by Borrull, Aurelie, Ghislin, Stephanie, Deshayes, Frederique, Lauriol, Jessica, Alcaide-Loridan, Catherine, Middendorp, Sandrine

“…Purpose Melanoma tumors are highly heterogeneous and can undergo phenotypic modifications depending on their plasticity and the microenvironment, with shifts…”
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Plasticity of melanoma cells induced by neural cell crest conditions and three-dimensional growth by Ghislin, Stephanie, Deshayes, Frederique, Lauriol, Jessica, Middendorp, Sandrine, Martins, Isabelle, Al-Daccak, Reem, Alcaide-Loridan, Catherine

“…Melanoma tumors have been shown to comprise both invasive and proliferative cell subpopulations. These populations are highly plastic, thus hampering full…”
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Chronic Hypergravity Induces a Modification of Histone H3 Lysine 27 Trimethylation at TCRβ Locus in Murine Thymocytes by Calcagno, Gaetano, Ouzren, Nassima, Kaminski, Sandra, Ghislin, Stéphanie, Frippiat, Jean-Pol

“…Gravity changes are major stressors encountered during spaceflight that affect the immune system. We previously evidenced that hypergravity exposure during…”
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Plasticity of the human IgM repertoire in response to long‐term spaceflight by Buchheim, Judith‐Irina, Ghislin, Stéphanie, Ouzren, Nassima, Albuisson, Eliane, Vanet, Anne, Matzel, Sandra, Ponomarev, Sergey, Rykova, Marina, Choukér, Alexander, Frippiat, Jean‐Pol

“…Immune dysregulation is among the main adverse outcomes of spaceflight. Despite the crucial role of the antibody repertoire in host protection, the effects of…”
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Long-duration head-down tilt bed rest confirms the relevance of the neutrophil to lymphocyte ratio and suggests coupling it with the platelet to lymphocyte ratio to monitor the immune health of astronauts by Jacob, Pauline, Bonnefoy, Julie, Ghislin, Stéphanie, Frippiat, Jean-Pol

“…The identification of safe and easily-determined-inflight biomarkers to monitor the immune system of astronauts is mandatory to ensure their well-being and the…”
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Analysis of femurs from mice embarked on board BION‐M1 biosatellite reveals a decrease in immune cell development, including B cells, after 1 wk of recovery on Earth by Tascher, Georg, Gerbaix, Maude, Maes, Pauline, Chazarin, Blandine, Ghislin, Stéphanie, Antropova, Evgenia, Vassilieva, Galina, Ouzren-Zarhloul, Nassima, Gauquelin-Koch, Guillemette, Vico, Laurence, Frippiat, Jean-Pol, Bertile, Fabrice

“…ABSTRACT Bone loss and immune dysregulation are among the main adverse outcomes of spaceflight challenging astronauts' health and safety. However, consequences…”
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Hindlimb unloading, a physiological model of microgravity, modifies the murine bone marrow IgM repertoire in a similar manner as aging but less strongly by Fonte, Coralie, Jacob, Pauline, Vanet, Anne, Ghislin, Stéphanie, Frippiat, Jean-Pol

“…Background The spaceflight environment is an extreme environment that affects the immune system of approximately 50% of astronauts. With planned long-duration…”
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Gravitational Experimental Platform for Animal Models, a New Platform at ESA's Terrestrial Facilities to Study the Effects of Micro- and Hypergravity on Aquatic and Rodent Animal Models by Bonnefoy, Julie, Ghislin, Stéphanie, Beyrend, Jérôme, Coste, Florence, Calcagno, Gaetano, Lartaud, Isabelle, Gauquelin-Koch, Guillemette, Poussier, Sylvain, Frippiat, Jean-Pol

“…Using rotors to expose animals to different levels of hypergravity is an efficient means of understanding how altered gravity affects physiological functions,…”
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B-Cell Homeostasis Is Maintained During Two Months of Head-Down Tilt Bed Rest With or Without Antioxidant Supplementation by Bonnefoy, Julie, Baselet, Bjorn, Moser, Dominique, Ghislin, Stéphanie, Miranda, Silvana, Riant, Elodie, Vermeesen, Randy, Keiler, Annekathrin M, Baatout, Sarah, Choukér, Alexander, Frippiat, Jean-Pol

“…Alterations of the immune system could seriously impair the ability to combat infections during future long-duration space missions. However, little is known…”
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Modulation of Iberian Ribbed Newt Complement Component C3 by Stressors Similar to those Encountered during a Stay Onboard the International Space Station by Guéguinou, Nathan, Jeandel, Jérémy, Kaminski, Sandra, Baatout, Sarah, Ghislin, Stéphanie, Frippiat, Jean-Pol

“…The complement system plays an important role in inflammation, innate and acquired immunity, as well as homeostasis. Despite these functions, the effects of…”
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Socioenvironmental stressors encountered during spaceflight partially affect the murine TCR‐β repertoire and increase its self‐reactivity by Fonte, Coralie, Kaminski, Sandra, Vanet, Anne, Lanfumey, Laurence, Cohen-Salmon, Charles, Ghislin, Stéphanie, Frippiat, Jean-Pol

“…ABSTRACT Spaceflights are known to affect the immune system. In a previous study, we demonstrated that hypergravity exposure during murine development modified…”
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Hypergravity exposure during gestation modifies the TCRβ repertoire of newborn mice by Ghislin, Stéphanie, Ouzren-Zarhloul, Nassima, Kaminski, Sandra, Frippiat, Jean-Pol

“…During spaceflight, organisms are subjected to mechanical force changes (gravity (G) changes) that affect the immune system. However, gravitational effects on…”
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The urodele amphibian Pleurodeles waltl has a diverse repertoire of immunoglobulin heavy chains with polyreactive and species-specific features by Fonte, Coralie, Gruez, Arnaud, Ghislin, Stéphanie, Frippiat, Jean-Pol

“…Urodele amphibians are an interesting model because although they possess the cardinal elements of the vertebrate immune system, their immune response is…”
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Molecular cloning and expression analysis of Pleurodeles waltl complement component C3 under normal physiological conditions and environmental stresses by Guéguinou, Nathan, Huin-Schohn, Cécile, Ouzren-Zarhloul, Nassima, Ghislin, Stéphanie, Frippiat, Jean-Pol

“…•First complete urodele amphibian C3 complement sequence.•C3 mRNA expression during neurulation.•Environmental stress increase C3 transcription suggesting…”
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Junctional adhesion molecules are required for melanoma cell lines transendothelial migration in vitro by Ghislin, Stephanie, Obino, Dorian, Middendorp, Sandrine, Boggetto, Nicole, Alcaide-Loridan, Catherine, Deshayes, Frederique

“…Summary One of the main steps of metastasis is extravasation, a phenomenon well described in lymphocytes but remaining to be fully uncovered for melanoma…”
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Coexpression of major histocompatibility complex class II with chemokines and nuclear NFκB p50 in melanoma: a rational for their association with poor prognosis by Martins, Isabelle, Sylla, Khaoussou, Deshayes, Frederique, Lauriol, Jessica, Ghislin, Stephanie, Dieu-Nosjean, Marie-Caroline, Viguier, Manuelle, Verola, Olivier, Charron, Dominique, Alcaide-Loridan, Catherine, Al-Daccak, Reem

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Plasticity of the human IgM repertoire in response to long-term spaceflight: Running title: Diversity of cosmonaut IgM repertoire by Buchheim, Judith-Irina, Ghislin, Stéphanie, Ouzren, Nassima, Albuisson, Eliane, Vanet, Anne, Matzel, Sandra, Ponomarev, Sergey, Rykova, Marina, Choukér, Alexander, Frippiat, Jean-Pol

“…Immune dysregulation is among the main adverse outcomes of spaceflight. Despite the crucial role of the antibody repertoire in host protection, the effects of…”
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