Search Results - "Ghislain, M."

Real-time impedance monitoring of oxygen reduction during surface modification of thin film cathodes by Rupp, Ghislain M., Opitz, Alexander K., Nenning, Andreas, Limbeck, Andreas, Fleig, Jürgen

“…Improvement of solid oxide fuel cells strongly relies on the development of cathode materials with high catalytic activity for the oxygen reduction reaction…”
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A Small Molecule Promotes Mitochondrial Fusion in Mammalian Cells by Wang, Danling, Wang, Jianing, Bonamy, Ghislain M. C., Meeusen, Shelly, Brusch, Richard G., Turk, Carolina, Yang, Pengyu, Schultz, Peter G.

“…Mitochondrial dynamics: An image‐based screen identified a small molecule, M1, that specifically promotes the fusion of fragmented mitochondria and protects…”
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A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis by Manjunatha, Ujjini H., Vinayak, Sumiti, Zambriski, Jennifer A., Chao, Alexander T., Sy, Tracy, Noble, Christian G., Bonamy, Ghislain M. C., Kondreddi, Ravinder R., Zou, Bin, Gedeck, Peter, Brooks, Carrie F., Herbert, Gillian T., Sateriale, Adam, Tandel, Jayesh, Noh, Susan, Lakshminarayana, Suresh B., Lim, Siau H., Goodman, Laura B., Bodenreider, Christophe, Feng, Gu, Zhang, Lijun, Blasco, Francesca, Wagner, Juergen, Leong, F. Joel, Striepen, Boris, Diagana, Thierry T.

“…Diarrhoeal disease is responsible for 8.6% of global child mortality. Recent epidemiological studies found the protozoan parasite Cryptosporidium to be a…”
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How To Get Mechanistic Information from Partial Pressure-Dependent Current–Voltage Measurements of Oxygen Exchange on Mixed Conducting Electrodes by Schmid, Alexander, Rupp, Ghislain M, Fleig, Jürgen

“…The oxygen incorporation and evolution reaction on mixed conducting electrodes of solid oxide fuel or electrolysis cells involves gas molecules as well as…”
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Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery by Meister, Stephan, Plouffe, David M., Kuhen, Kelli L., Bonamy, Ghislain M. C., Wu, Tao, Barnes, S. Whitney, Bopp, Selina E., Borboa, Rachel, Bright, A. Taylor, Che, Jianwei, Cohen, Steve, Dharia, Neekesh V., Gagaring, Kerstin, Gettayacamin, Montip, Gordon, Perry, Groessl, Todd, Kato, Nobutaka, Lee, Marcus C. S., McNamara, Case W., Fidock, David A., Nagle, Advait, Nam, Tae-gyu, Richmond, Wendy, Roland, Jason, Rottmann, Matthias, Zhou, Bin, Froissard, Patrick, Glynne, Richard J., Mazier, Dominique, Sattabongkot, Jetsumon, Schultz, Peter G., Tuntland, Tove, Walker, John R., Zhou, Yingyao, Chatterjee, Arnab, Diagana, Thierry T., Winzeler, Elizabeth A.

“…Most malaria drug development focuses on parasite stages detected in red blood cells, even though, to achieve eradication, next-generation drugs active against…”
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The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα by Britschgi, Adrian, Duss, Stephan, Kim, Sungeun, Couto, Joana Pinto, Brinkhaus, Heike, Koren, Shany, De Silva, Duvini, Mertz, Kirsten D., Kaup, Daniela, Varga, Zsuzsanna, Voshol, Hans, Vissieres, Alexandra, Leroy, Cedric, Roloff, Tim, Stadler, Michael B., Scheel, Christina H., Miraglia, Loren J., Orth, Anthony P., Bonamy, Ghislain M. C., Reddy, Venkateshwar A., Bentires-Alj, Mohamed

“…Ablation of the large tumour suppressor kinases 1 and 2 promotes a luminal breast cell phenotype through stabilization of oestrogen receptor-α, thereby…”
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A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi by Voorberg-van der Wel, Annemarie, Roma, Guglielmo, Gupta, Devendra Kumar, Schuierer, Sven, Nigsch, Florian, Carbone, Walter, Zeeman, Anne-Marie, Lee, Boon Heng, Hofman, Sam O, Faber, Bart W, Knehr, Judith, Pasini, Erica, Kinzel, Bernd, Bifani, Pablo, Bonamy, Ghislain M C, Bouwmeester, Tewis, Kocken, Clemens H M, Diagana, Thierry Tidiane

“…liver hypnozoites, which cause disease relapse, are widely considered to be the last barrier towards malaria eradication. The biology of this quiescent form of…”
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The Chemical Evolution of the La0.6Sr0.4CoO3−δ Surface Under SOFC Operating Conditions and Its Implications for Electrochemical Oxygen Exchange Activity by Opitz, Alexander K., Rameshan, Christoph, Kubicek, Markus, Rupp, Ghislain M., Nenning, Andreas, Götsch, Thomas, Blume, Raoul, Hävecker, Michael, Knop-Gericke, Axel, Rupprechter, Günther, Klötzer, Bernhard, Fleig, Jürgen

“…Owing to its extraordinary high activity for catalysing the oxygen exchange reaction, strontium doped LaCoO 3 (LSC) is one of the most promising materials for…”
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FGFR2 promotes breast tumorigenicity through maintenance of breast tumor-initiating cells by Kim, Sungeun, Dubrovska, Anna, Salamone, Richard J, Walker, John R, Grandinetti, Kathryn B, Bonamy, Ghislain M C, Orth, Anthony P, Elliott, Jimmy, Porta, Diana Graus, Garcia-Echeverria, Carlos, Reddy, Venkateshwar A

“…Emerging evidence suggests that some cancers contain a population of stem-like TICs (tumor-initiating cells) and eliminating TICs may offer a new strategy to…”
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Bioengineering potato plants to produce benzylglucosinolate for improved broad-spectrum pest and disease resistance by González-Romero, M. E., Rivera, C., Cancino, K., Geu-Flores, F., Cosio, E. G., Ghislain, M., Halkier, B. A.

“…In traditional, small-scale agriculture in the Andes, potatoes are frequently co-cultivated with the Andean edible tuber Tropaeolum tuberosum, commonly known…”
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Imidazolopiperazines Kill both Rings and Dormant Rings in Wild-Type and K13 Artemisinin-Resistant Plasmodium falciparum In Vitro by Dembele, Laurent, Gupta, Devendra Kumar, Lim, Michelle Yi-Xiu, Ang, Xiaoman, Selva, Jeremy J, Chotivanich, Kesinee, Nguon, Chea, Dondorp, Arjen M, Bonamy, Ghislain M C, Diagana, Thierry T, Bifani, Pablo

“…Artemisinin (ART) resistance has spread through Southeast Asia, posing a serious threat to the control and elimination of malaria. ART resistance has been…”
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A Chemical Genomic Analysis of Decoquinate, a Plasmodium falciparum Cytochrome b Inhibitor by Nam, Tae-gyu, McNamara, Case W, Bopp, Selina, Dharia, Neekesh V, Meister, Stephan, Bonamy, Ghislain M. C, Plouffe, David M, Kato, Nobutaka, McCormack, Susan, Bursulaya, Badry, Ke, Hangjun, Vaidya, Akhil B, Schultz, Peter G, Winzeler, Elizabeth A

“…Decoquinate has single-digit nanomolar activity against in vitro blood stage Plasmodium falciparum parasites, the causative agent of human malaria. In vitro…”
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Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication by König, Renate, Zhou, Yingyao, Elleder, Daniel, Diamond, Tracy L., Bonamy, Ghislain M.C., Irelan, Jeffrey T., Chiang, Chih-yuan, Tu, Buu P., De Jesus, Paul D., Lilley, Caroline E., Seidel, Shannon, Opaluch, Amanda M., Caldwell, Jeremy S., Weitzman, Matthew D., Kuhen, Kelli L., Bandyopadhyay, Sourav, Ideker, Trey, Orth, Anthony P., Miraglia, Loren J., Bushman, Frederic D., Young, John A., Chanda, Sumit K.

“…Human Immunodeficiency Viruses (HIV-1 and HIV-2) rely upon host-encoded proteins to facilitate their replication. Here, we combined genome-wide siRNA analyses…”
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Efficacy of HD201 vs Referent Trastuzumab in Patients With ERBB2-Positive Breast Cancer Treated in the Neoadjuvant Setting: A Multicenter Phase 3 Randomized Clinical Trial by Pivot, Xavier, Georgievich, M A, Shamrai, Volodymyr, Dzagnidze, Giorgi, Soo Hoo, Hwoei Fen, Kaewkangsadan, Viriya, Petrelli, Fausto, Villanueva, Cristian, Nikolaevich, Lipatov O, Hii, Jocelyn, Kim, Jamie, Pradhan, Sumita, Jaison, Litha, Feyaerts, Peggy, Kaufman, Leonard, Derde, Marie-Paule, Bonamy, Ghislain M C, Deforce, Filip, Cox, David G

“…The drug HD201 is a biosimilar candidate for breast cancer treatment as the reference trastuzumab. To compare the efficacy of HD201 with referent trastuzumab…”
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The Natural Product Cavinafungin Selectively Interferes with Zika and Dengue Virus Replication by Inhibition of the Host Signal Peptidase by Estoppey, David, Lee, Chia Min, Janoschke, Marco, Lee, Boon Heng, Wan, Kah Fei, Dong, Hongping, Mathys, Philippe, Filipuzzi, Ireos, Schuhmann, Tim, Riedl, Ralph, Aust, Thomas, Galuba, Olaf, McAllister, Gregory, Russ, Carsten, Spiess, Martin, Bouwmeester, Tewis, Bonamy, Ghislain M.C., Hoepfner, Dominic

“…Flavivirus infections by Zika and dengue virus impose a significant global healthcare threat with no US Food and Drug Administration (FDA)-approved vaccination…”
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Operando X‑ray Investigation of Electrode/Electrolyte Interfaces in Model Solid Oxide Fuel Cells by Volkov, Sergey, Vonk, Vedran, Khorshidi, Navid, Franz, Dirk, Kubicek, Markus, Kilic, Volkan, Felici, Roberto, Huber, Tobias M, Navickas, Edvinas, Rupp, Ghislain M, Fleig, Jürgen, Stierle, Andreas

“…We employed operando anomalous surface X-ray diffraction to investigate the buried interface between the cathode and the electrolyte of a model solid oxide…”
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UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes by Lim, Michelle Yi-Xiu, LaMonte, Gregory, Lee, Marcus C. S., Reimer, Christin, Tan, Bee Huat, Corey, Victoria, Tjahjadi, Bianca F., Chua, Adeline, Nachon, Marie, Wintjens, René, Gedeck, Peter, Malleret, Benoit, Renia, Laurent, Bonamy, Ghislain M. C., Ho, Paul Chi-Lui, Yeung, Bryan K. S., Chow, Eric D., Lim, Liting, Fidock, David A., Diagana, Thierry T., Winzeler, Elizabeth A., Bifani, Pablo

“…A molecular understanding of drug resistance mechanisms enables surveillance of the effectiveness of new antimicrobial therapies during development and…”
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Correction to: Bioengineering potato plants to produce benzylglucosinolate for improved broad-spectrum pest and disease resistance by González-Romero, M. E., Rivera, C., Cancino, K., Geu-Flores, F., Cosio, E. G., Ghislain, M., Halkier, B. A.

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Botanical from the medicinal spice, Piper capense is safe as demonstrated by oral acute and subchronic toxicity investigations by Wamba, Brice E.N., Mbaveng, Armelle T., Tazoho, Ghislain M., Kuete, Victor

“…Piper capense Linn is a plant used in Cameroon to treat cancer and several other diseases such as urinary tract disorder, fever, stomach-ache and to improve…”
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Discovery of 2-oxopiperazine dengue inhibitors by scaffold morphing of a phenotypic high-throughput screening hit by Kounde, Cyrille S., Yeo, Hui-Quan, Wang, Qing-Yin, Wan, Kah Fei, Dong, Hongping, Karuna, Ratna, Dix, Ina, Wagner, Trixie, Zou, Bin, Simon, Oliver, Bonamy, Ghislain M.C., Yeung, Bryan K.S., Yokokawa, Fumiaki

“…[Display omitted] A series of 2-oxopiperazine derivatives were designed from the pyrrolopiperazinone cell-based screening hit 4 as a dengue virus inhibitor…”
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