Search Results - "Ghirardello, Mattia"

Carbon Dots as an Emergent Class of Antimicrobial Agents by Ghirardello, Mattia, Ramos-Soriano, Javier, Galan, M Carmen

“…Antimicrobial resistance is a recognized global challenge. Tools for bacterial detection can combat antimicrobial resistance by facilitating evidence-based…”
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Recent Advances on Multivalent Carbon Nanoform-Based Glycoconjugates by Ramos-Soriano, Javier, Ghirardello, Mattia, Galan, M Carmen

“…Multivalent carbohydrate-mediated interactions are key to many biological processes including disease mechanisms. In order to study these important…”
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Author Correction: Molecular basis for bacterial N-glycosylation by a soluble HMW1C-like N-glycosyltransferase by Piniello, Beatriz, Macías-León, Javier, Miyazaki, Shun, García-García, Ana, Compañón, Ismael, Ghirardello, Mattia, Taleb, Víctor, Veloz, Billy, Corzana, Francisco, Miyagawa, Atsushi, Rovira, Carme, Hurtado-Guerrero, Ramon

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Molecular basis for bacterial N-glycosylation by a soluble HMW1C-like N-glycosyltransferase by Piniello, Beatriz, Macías-León, Javier, Miyazaki, Shun, García-García, Ana, Compañón, Ismael, Ghirardello, Mattia, Taleb, Víctor, Veloz, Billy, Corzana, Francisco, Miyagawa, Atsushi, Rovira, Carme, Hurtado-Guerrero, Ramon

“…Soluble HMW1C-like N -glycosyltransferases (NGTs) catalyze the glycosylation of Asn residues in proteins, a process fundamental for bacterial autoaggregation,…”
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Glioma Stem-Like Cells and Metabolism: Potential for Novel Therapeutic Strategies by Harland, Abigail, Liu, Xia, Ghirardello, Mattia, Galan, M. Carmen, Perks, Claire M., Kurian, Kathreena M.

“…Glioma stem-like cells (GSCs) were first described as a population which may in part be resistant to traditional chemotherapeutic therapies and responsible for…”
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Rational Design of Dual-Domain Binding Inhibitors for N‑Acetylgalactosamine Transferase 2 with Improved Selectivity over the T1 and T3 Isoforms by Compañón, Ismael, Ballard, Collin J., Lira-Navarrete, Erandi, Santos, Tanausú, Monaco, Serena, Muñoz-García, Juan C., Delso, Ignacio, Angulo, Jesus, Gerken, Thomas A., Schjoldager, Katrine T., Clausen, Henrik, Tejero, Tomás, Merino, Pedro, Corzana, Francisco, Hurtado-Guerrero, Ramon, Ghirardello, Mattia

“…The GalNAc-transferase (GalNAc-T) family, consisting of 20 isoenzymes, regulates the O-glycosylation process of mucin glycopeptides by transferring GalNAc…”
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Recent advances on the enantioselective synthesis of C-nucleosides inhibitors of inosine monophosphate dehydrogenase (IMPDH) by Merino, Pedro, Ghirardello, Mattia, Tejero, Tomas, Delso, Ignacio, Matute, Rosa

“…This review will describe the recent advances in the synthesis of C-nucleosides with inhibitory activity of inosine monophosphate dehydrogenase (IMPDH), a key…”
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Carbon-based glyco-nanoplatforms: towards the next generation of glycan-based multivalent probes by Ramos-Soriano, Javier, Ghirardello, Mattia, Galan, M Carmen

“…Cell surface carbohydrates mediate a wide range of carbohydrate-protein interactions key to healthy and disease mechanisms. Many of such interactions are…”
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Reengineering of cancer cell surface charges can modulate cell migration by Ghirardello, Mattia, Shyam, Radhe, Galan, M Carmen

“…The ability to modulate the cell surface structure provides a powerful tool to understand fundamental processes and also to elicit desired cellular responses…”
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Recent applications of ionic liquid-based tags in glycoscience by Ghirardello, Mattia, Zhang, Yao-Yao, Voglmeir, Josef, Galan, M. Carmen

“…The functionalization of glycosides with ionic compounds such as ionic liquids provides enhanced polarity for the labelled glycans thanks to the presence of a…”
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Synthesis of Chiral Ionic Liquids from Natural Monosaccharides by Ghirardello, Mattia, Costantini, Maira, Vecchi, Alessandra, Pacifico, Salvatore, Pazzi, Daniele, Castiglione, Franca, Mele, Andrea, Marra, Alberto

“…Three series of new ionic liquids (ILs), namely imidazolium‐, pyrazolium‐, and bis‐benzimidazolium‐containing ILs, were prepared from low‐cost, unprotected…”
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High sensitivity profiling of N-glycans from mouse serum using fluorescent imidazolium tags by HILIC electrospray ionisation spectrometry by Zhang, Yao-Yao, Zhang, Si-Yu, Hu, Zi-Xuan, Voglmeir, Josef, Liu, Li, Galan, M. Carmen, Ghirardello, Mattia

“…N-linked glycosylation is a ubiquitous protein post-translational modification in which aberrant glycan biosynthesis has been linked to severe conditions like…”
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Non-natural MUC1 Glycopeptide Homogeneous Cancer Vaccine with Enhanced Immunogenicity and Therapeutic Activity by Guerreiro, Ana, Compañón, Ismael, Lazaris, Foivos S, Labão-Almeida, Carlos, Oroz, Paula, Ghirardello, Mattia, Marques, Marta C, Corzana, Francisco, Bernardes, Gonçalo J L

“…Glycopeptides derived from the glycoprotein mucin-1 (MUC1) have shown potential as tumor-associated antigens for cancer vaccine development. However, their low…”
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Exploiting structure-activity relationships of QS-21 in the design and synthesis of streamlined saponin vaccine adjuvants by Ghirardello, Mattia, Ruiz-de-Angulo, Ane, Sacristan, Nagore, Barriales, Diego, Jiménez-Barbero, Jesús, Poveda, Ana, Corzana, Francisco, Anguita, Juan, Fernández-Tejada, Alberto

“…We report the design, synthesis, immunological evaluation, and conformational analysis of new saponin variants as promising vaccine adjuvants. These studies…”
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Chemo-selective Rh-catalysed hydrogenation of azides into amines by Ghirardello, Mattia, Ledru, Helene, Sau, Abhijit, Galan, M. Carmen

“…Rh/Al2O3 can be used as an effective chemo-selective reductive catalyst that combines the mild conditions of catalytic hydrogenation with high selectivity for…”
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Imidazolium labelling permits the sensitive mass-spectrometric detection of N -glycosides directly from serum by Zhang, Yao-Yao, Ghirardello, Mattia, Wang, Ting, Lu, Ai-Min, Liu, Li, Voglmeir, Josef, Galan, M Carmen

“…A novel imidazolium derivative (GITag) shows superior ionisation and consequently allows increased mass spectrometric detection capabilities of…”
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Benefits of Chemical Sugar Modifications Introduced by Click Chemistry for Glycoproteomic Analyses by Calle, Beatriz, Bineva-Todd, Ganka, Marchesi, Andrea, Flynn, Helen, Ghirardello, Mattia, Tastan, Omur Y, Roustan, Chloe, Choi, Junwon, Galan, M. Carmen, Schumann, Benjamin, Malaker, Stacy A

“…Mucin-type O-glycosylation is among the most complex post-translational modifications. Despite mediating many physiological processes, O-glycosylation remains…”
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Multicolor Photoluminescent Carbon Dots à La Carte for Biomedical Applications by Garcia-Millan, Teodoro, Ramos-Soriano, Javier, Ghirardello, Mattia, Liu, Xia, Santi, Cristina Manuela, Eloi, Jean-Charles, Pridmore, Natalie, Harniman, Robert L., Morgan, David J., Hughes, Stephen, Davis, Sean A., Oliver, Thomas A. A., Kurian, Kathreena M., Galan, M. Carmen

“…Dual-emission fluorescence probes that provide high sensitivity are key for biomedical diagnostic applications. Nontoxic carbon dots (CDs) are an emerging…”
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Microfluidics-Based Ionic Catch and Release Oligosaccharide Synthesis (ICROS-Microflow) to Expedite Glycosylation Chemistry by Zhang, Yao-Yao, Ghirardello, Mattia, Williams, Ryan, Diaz, Adrian Silva, Rojo, Javier, Voglmeir, Josef, Ramos-Soriano, Javier, Galan, M. Carmen

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Reverse thiophosphorylase activity of a glycoside phosphorylase in the synthesis of an unnatural Manβ1,4GlcNAc library by Keenan, Tessa, Hatton, Natasha E, Porter, Jack, Vendeville, Jean-Baptiste, Wheatley, David E, Ghirardello, Mattia, Wahart, Alice. J. C, Ahmadipour, Sanaz, Walton, Julia, Galan, M. Carmen, Linclau, Bruno, Miller, Gavin J, Fascione, Martin A

“…β-Mannosides are ubiquitous in nature, with diverse roles in many biological processes. Notably, Manβ1,4GlcNAc a constituent of the core N -glycan in…”
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