Search Results - "Ghigna, Claudia"

Alternative splicing in Alzheimer’s disease by Biamonti, Giuseppe, Amato, Angela, Belloni, Elisa, Di Matteo, Anna, Infantino, Lucia, Pradella, Davide, Ghigna, Claudia

“…Alzheimer’s disease (AD) is the most frequent neurodegenerative disorder in the elderly, occurring in approximately 20% of people older than 80. The molecular…”
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A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis by Pradella, Davide, Deflorian, Gianluca, Pezzotta, Alex, Di Matteo, Anna, Belloni, Elisa, Campolungo, Daniele, Paradisi, Andrea, Bugatti, Mattia, Vermi, William, Campioni, Matteo, Chiapparino, Antonella, Scietti, Luigi, Forneris, Federico, Giampietro, Costanza, Volf, Nina, Rehman, Michael, Zacchigna, Serena, Paronetto, Maria Paola, Pistocchi, Anna, Eichmann, Anne, Mehlen, Patrick, Ghigna, Claudia

“…The Netrin-1 receptor UNC5B is an axon guidance regulator that is also expressed in endothelial cells (ECs), where it finely controls developmental and tumor…”
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Making alternative splicing decisions during epithelial-to-mesenchymal transition (EMT) by Biamonti, Giuseppe, Bonomi, Serena, Gallo, Stefania, Ghigna, Claudia

“…Alternative splicing generates multiple mRNAs from a single transcript and is a major contributor to proteomic diversity and to the control of gene expression…”
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SAM68: Signal Transduction and RNA Metabolism in Human Cancer by Ghigna, Claudia, Belloni, Elisa, Di Matteo, Anna, Pradella, Davide, Frisone, Paola, Paronetto, Maria Paola

“…Alterations in expression and/or activity of splicing factors as well as mutations in cis-actingsplicing regulatory sequences contribute to cancer phenotypes…”
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Sam68 regulates EMT through alternative splicing-activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene by Valacca, Cristina, Bonomi, Serena, Buratti, Emanuele, Pedrotti, Simona, Baralle, Francisco Ernesto, Sette, Claudio, Ghigna, Claudia, Biamonti, Giuseppe

“…Epithelial-to-mesenchymal transition (EMT) and its reversal (MET) are crucial cell plasticity programs that act during development and tumor metastasis. We…”
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Diversification of the muscle proteome through alternative splicing by Nakka, Kiran, Ghigna, Claudia, Gabellini, Davide, Dilworth, F Jeffrey

“…Skeletal muscles express a highly specialized proteome that allows the metabolism of energy sources to mediate myofiber contraction. This muscle-specific…”
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Alternative splicing in endothelial cells: novel therapeutic opportunities in cancer angiogenesis by Di Matteo, Anna, Belloni, Elisa, Pradella, Davide, Cappelletto, Ambra, Volf, Nina, Zacchigna, Serena, Ghigna, Claudia

“…Alternative splicing (AS) is a pervasive molecular process generating multiple protein isoforms, from a single gene. It plays fundamental roles during…”
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Alternative Splicing: Recent Insights into Mechanisms and Functional Roles by Ghigna, Claudia, Paronetto, Maria Paola

“…Alternative splicing generates multiple protein isoforms from one primary transcript and represents one of the major drivers of proteomic diversity in human…”
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Alternative Splicing and Tumor Progression by Ghigna, Claudia, Valacca, Cristina, Biamonti, Giuseppe

“…Alternative splicing is a key molecular mechanism for increasing the functional diversity of the eukaryotic proteomes. A large body of experimental data…”
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Relative strength of 5’ splice-site strength defines functions of SRSF2 and SRSF6 in alternative splicing of Bcl-x pre-mRNA by Choi, Namjeong, Liu, Yongchao, Oh, Jagyeong, Ha, Jiyeon, Ghigna, Claudia, Zheng, Xuexiu, Shen, Haihong

“…Bcl-x, a member of the Bcl-2 family, plays a key role in apoptosis. Alternative splicing of Bcl-x pre-mRNA through alternative 5’ splice-site selection…”
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Transcription of Satellite III non-coding RNAs is a general stress response in human cells by Valgardsdottir, Rut, Chiodi, Ilaria, Giordano, Manuela, Rossi, Antonio, Bazzini, Silvia, Ghigna, Claudia, Riva, Silvano, Biamonti, Giuseppe

“…In heat-shocked human cells, heat shock factor 1 activates transcription of tandem arrays of repetitive Satellite III (SatIII) DNA in pericentromeric…”
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Alternative Splicing Changes Promoted by NOVA2 Upregulation in Endothelial Cells and Relevance for Gastric Cancer by Di Matteo, Anna, Belloni, Elisa, Pradella, Davide, Chiaravalli, Anna Maria, Pini, Giacomo Maria, Bugatti, Mattia, Alfieri, Roberta, Barzan, Chiara, Franganillo Tena, Elena, Bione, Silvia, Terenzani, Elisa, Sessa, Fausto, Wyatt, Christopher D R, Vermi, William, Ghigna, Claudia

“…Angiogenesis is crucial for cancer progression. While several anti-angiogenic drugs are in use for cancer treatment, their clinical benefits are…”
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Clinical Significance and Regulation of ERK5 Expression and Function in Cancer by Monti, Matilde, Celli, Jacopo, Missale, Francesco, Cersosimo, Francesca, Russo, Mariapia, Belloni, Elisa, Di Matteo, Anna, Lonardi, Silvia, Vermi, William, Ghigna, Claudia, Giurisato, Emanuele

“…Extracellular signal-regulated kinase 5 (ERK5) is a unique kinase among MAPKs family members, given its large structure characterized by the presence of a…”
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Oncogenic Alternative Splicing Switches: Role in Cancer Progression and Prospects for Therapy by Gallo, Stefania, Bonomi, Serena, Catillo, Morena, Pignataro, Daniela, Biamonti, Giuseppe, Ghigna, Claudia

“…Alterations in the abundance or activities of alternative splicing regulators generate alternatively spliced variants that contribute to multiple aspects of…”
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A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing by Angiolini, Francesca, Belloni, Elisa, Giordano, Marco, Campioni, Matteo, Forneris, Federico, Paronetto, Maria Paola, Lupia, Michela, Brandas, Chiara, Pradella, Davide, Di Matteo, Anna, Giampietro, Costanza, Jodice, Giovanna, Luise, Chiara, Bertalot, Giovanni, Freddi, Stefano, Malinverno, Matteo, Irimia, Manuel, Moulton, Jon D, Summerton, James, Chiapparino, Antonella, Ghilardi, Carmen, Giavazzi, Raffaella, Nyqvist, Daniel, Gabellini, Davide, Dejana, Elisabetta, Cavallaro, Ugo, Ghigna, Claudia

“…The biological players involved in angiogenesis are only partially defined. Here, we report that endothelial cells (ECs) express a novel isoform of the…”
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Regulation of the Ras-MAPK and PI3K-mTOR Signalling Pathways by Alternative Splicing in Cancer by Siegfried, Zahava, Bonomi, Serena, Ghigna, Claudia, Karni, Rotem

“…Alternative splicing is a fundamental step in regulation of gene expression of many tumor suppressors and oncogenes in cancer. Signalling through the Ras-MAPK…”
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Alternative splicing and muscular dystrophy by Pistoni, Mariaelena, Ghigna, Claudia, Gabellini, Davide

“…Alternative splicing of pre-mRNAs is a major contributor to proteomic diversity and to the control of gene expression in higher eukaryotic cells. For this…”
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Widespread Alternative Splicing Changes in Metastatic Breast Cancer Cells by Oh, Jagyeong, Pradella, Davide, Shao, Changwei, Li, Hairi, Choi, Namjeong, Ha, Jiyeon, Ruggiero, Sonia, Fu, Xiang-Dong, Zheng, Xuexiu, Ghigna, Claudia, Shen, Haihong

“…Aberrant alternative splicing (AS) is a hallmark of cancer and a potential target for novel anti-cancer therapeutics. Breast cancer-associated AS events are…”
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SRSF9 Regulates Cassette Exon Splicing of Caspase-2 by Interacting with Its Downstream Exon by Ha, Jiyeon, Jang, Hana, Choi, Namjeong, Oh, Jagyeong, Min, Chanhyuk, Pradella, Davide, Jung, Da-Woon, Williams, Darren R, Park, Daeho, Ghigna, Claudia, Zheng, Xuexiu, Shen, Haihong

“…Alternative splicing (AS) is an important posttranscriptional regulatory process. Damaged or unnecessary cells need to be removed though apoptosis to maintain…”
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Relative strength of 5’ splice-site strength defines functions of SRSF2 and SRSF6 in alternative splicing of Bcl-x pre-mRNA by Choi, Namjeong, Liu, Yongchao, Oh, Jagyeong, Ha, Jiyeon, Ghigna, Claudia, Zheng, Xuexiu, Shen, Haihong

“…Bcl-x, a member of the Bcl-2 family, plays a key role in apoptosis. Alternative splicing of Bcl-x pre-mRNA through alternative 5’ splice-site selection…”
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