Search Results - "Ghidewon, Misgana Y"

GIP Receptor Agonism Attenuates GLP-1 Receptor Agonist-Induced Nausea and Emesis in Preclinical Models by Borner, Tito, Geisler, Caroline E, Fortin, Samantha M, Cosgrove, Richard, Alsina-Fernandez, Jorge, Dogra, Mridula, Doebley, Sarah, Sanchez-Navarro, Marcos J, Leon, Rosa M, Gaisinsky, Jane, White, Arianna, Bamezai, Ankur, Ghidewon, Misgana Y, Grill, Harvey J, Crist, Richard C, Reiner, Benjamin C, Ai, Minrong, Samms, Ricardo J, De Jonghe, Bart C, Hayes, Matthew R

“…Glucagon-like peptide 1 receptor (GLP-1R) agonists decrease body weight and improve glycemic control in obesity and diabetes. Patient compliance and maximal…”
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GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss by Borner, Tito, Wald, Hallie S., Ghidewon, Misgana Y., Zhang, Bei, Wu, Zhidan, De Jonghe, Bart C., Breen, Danna, Grill, Harvey J.

“…The anorectic and weight-suppressive effects of growth differentiation factor-15 (GDF15) are attracting considerable attention for treating obesity. Current…”
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Hypophagia induced by salmon calcitonin, but not by amylin, is partially driven by malaise and is mediated by CGRP neurons by Boccia, Lavinia, Borner, Tito, Ghidewon, Misgana Y., Kulka, Patricia, Piffaretti, Chiara, Doebley, Sarah A., De Jonghe, Bart C., Grill, Harvey J., Lutz, Thomas A., Le Foll, Christelle

“…The behavioral mechanisms and the neuronal pathways mediated by amylin and its long-acting analog sCT (salmon calcitonin) are not fully understood and it is…”
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GDF15 Induces Anorexia through Nausea and Emesis by Borner, Tito, Shaulson, Evan D., Ghidewon, Misgana Y., Barnett, Amanda B., Horn, Charles C., Doyle, Robert P., Grill, Harvey J., Hayes, Matthew R., De Jonghe, Bart C.

“…Growth differentiation factor 15 (GDF15) is a cytokine that reduces food intake through activation of hindbrain GFRAL-RET receptors and has become a keen…”
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Hindbrain ghrelin and liver-expressed antimicrobial peptide 2, ligands for growth hormone secretagogue receptor, bidirectionally control food intake by Wald, Hallie S, Ghidewon, Misgana Y, Hayes, Matthew R, Grill, Harvey J

“…Hindbrain growth hormone secretagogue receptor (GHSR) agonism increases food intake, yet the underlying neural mechanisms remain unclear. The functional…”
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Topical application of a P2X2/P2X3 purine receptor inhibitor suppresses the bitter taste of medicines and other taste qualities by Flammer, Linda J., Ellis, Hillary, Rivers, Natasha, Caronia, Lauren, Ghidewon, Misgana Y., Christensen, Carol M., Jiang, Peihua, Breslin, Paul A. S., Tordoff, Michael G.

“…Background and Purpose Many medications taste intensely bitter. The innate aversion to bitterness affects medical compliance, especially in children. There is…”
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Dissociable hindbrain GLP1R circuits for satiety and aversion by Huang, Kuei-Pin, Acosta, Alisha A., Ghidewon, Misgana Y., McKnight, Aaron D., Almeida, Milena S., Nyema, Nathaniel T., Hanchak, Nicholas D., Patel, Nisha, Gbenou, Yenoukoume S. K., Adriaenssens, Alice E., Bolding, Kevin A., Alhadeff, Amber L.

“…The most successful obesity therapeutics, glucagon-like peptide-1 receptor (GLP1R) agonists, cause aversive responses such as nausea and vomiting 1 , 2 ,…”
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