Search Results - "Ghiasvand, Shabnam"
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Kinase Inhibitors with Antiepileptic Properties Identified with a Novel in Vitro Screening Platform
Published in International journal of molecular sciences (21-05-2019)“…Kinase signaling plays an important role in acquired epilepsy, but only a small percentage of the total kinome has been investigated in this context. A major…”
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Journal Article -
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Neuroprotective levels of IGF-1 exacerbate epileptogenesis after brain injury
Published in Scientific reports (26-08-2016)“…Exogenous Insulin-Like Growth Factor-1 (IGF-1) is neuroprotective in animal models of brain injury, and has been considered as a potential therapeutic…”
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Journal Article -
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Variability of seizure-like activity in an in vitro model of epilepsy depends on the electrical recording method
Published in Heliyon (01-11-2020)“…Hippocampal and cortical slice-based models are widely used to study seizures and epilepsy. Seizure detection and quantification are essential components for…”
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In-Vitro Assessment of Post-Traumatic Epileptogenesis
Published 01-01-2021“…An injury to the brain results in many different pathological processes that can eventually develop into an epilepsy etiology best known as posttraumatic…”
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Dissertation -
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Neural layer self-assembly in geometrically confined rat and human 3D cultures
Published in Biofabrication (01-08-2019)“…Neurological disorders affect millions of Americans and this number is expected to rise with the aging population. Development of drugs to treat these…”
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Journal Article -
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Epilepsy-on-a-Chip System for Antiepileptic Drug Discovery
Published in IEEE transactions on biomedical engineering (01-05-2019)“…Objective: Hippocampal slice cultures spontaneously develop chronic epilepsy several days after slicing and are used as an in vitro model of post-traumatic…”
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Journal Article