Search Results - "Ghetti, Bernardino"
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Structures of filaments from Pick’s disease reveal a novel tau protein fold
Published in Nature (London) (01-09-2018)“…The ordered assembly of tau protein into abnormal filamentous inclusions underlies many human neurodegenerative diseases 1 . Tau assemblies seem to spread…”
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2
Structure of Tau filaments in Prion protein amyloidoses
Published in Acta neuropathologica (01-08-2021)“…In human neurodegenerative diseases associated with the intracellular aggregation of Tau protein, the ordered cores of Tau filaments adopt distinct folds…”
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3
Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease
Published in The New England journal of medicine (30-08-2012)“…In this study of a cohort of adults with genetic mutations that cause autosomal dominant Alzheimer's disease, researchers identified abnormalities in…”
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Structure-based classification of tauopathies
Published in Nature (London) (14-10-2021)“…The ordered assembly of tau protein into filaments characterizes several neurodegenerative diseases, which are called tauopathies. It was previously reported…”
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Astroglial tracer BU99008 detects multiple binding sites in Alzheimer’s disease brain
Published in Molecular psychiatry (01-10-2021)“…With reactive astrogliosis being established as one of the hallmarks of Alzheimer’s disease (AD), there is high interest in developing novel positron emission…”
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6
Brain homogenates from human tauopathies induce tau inclusions in mouse brain
Published in Proceedings of the National Academy of Sciences - PNAS (04-06-2013)“…Filamentous inclusions made of hyperphosphorylated tau are characteristic of numerous human neurodegenerative diseases, including Alzheimer’s disease,…”
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Invited review: Frontotemporal dementia caused by microtubule-associated protein tau gene (MAPT) mutations: a chameleon for neuropathology and neuroimaging
Published in Neuropathology and applied neurobiology (01-02-2015)“…Hereditary frontotemporal dementia associated with mutations in the microtubule‐associated protein tau gene (MAPT) is a protean disorder. Three neuropathologic…”
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Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607
Published in Acta neuropathologica (01-05-2021)“…Tau and Aβ assemblies of Alzheimer’s disease (AD) can be visualized in living subjects using positron emission tomography (PET). Tau assemblies comprise paired…”
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9
Age-dependent formation of TMEM106B amyloid filaments in human brains
Published in Nature (London) (12-05-2022)“…Many age-dependent neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, are characterized by abundant inclusions of amyloid filaments. Filamentous…”
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10
Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease
Published in Acta neuropathologica (01-04-2019)“…Alzheimer disease (AD) and chronic traumatic encephalopathy (CTE) involve the abnormal accumulation in the brain of filaments composed of both three-repeat…”
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11
Phenotypic diversity of genetic Creutzfeldt–Jakob disease: a histo-molecular-based classification
Published in Acta neuropathologica (01-10-2021)“…The current classification of sporadic Creutzfeldt–Jakob disease (sCJD) includes six major clinicopathological subtypes defined by the physicochemical…”
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12
White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network
Published in Annals of neurology (01-06-2016)“…Objective White matter hyperintensities (WMHs) are areas of increased signal on T2‐weighted magnetic resonance imaging (MRI) scans that most commonly reflect…”
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13
Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC
Published in Acta neuropathologica communications (09-02-2018)“…The diagnosis and treatment of synucleinopathies such as Parkinson disease and dementia with Lewy bodies would be aided by the availability of assays for the…”
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14
Ultrasensitive and selective detection of 3-repeat tau seeding activity in Pick disease brain and cerebrospinal fluid
Published in Acta neuropathologica (01-05-2017)“…The diagnosis and treatment of diseases involving tau-based pathology such as Alzheimer disease and certain frontotemporal dementias is hampered by the…”
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15
Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease
Published in Proceedings of the National Academy of Sciences - PNAS (05-12-2017)“…The molecular architecture of amyloids formed in vivo can be interrogated using luminescent conjugated oligothiophenes (LCOs), a unique class of amyloid dyes…”
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16
Million-fold sensitivity enhancement in proteopathic seed amplification assays for biospecimens by Hofmeister ion comparisons
Published in Proceedings of the National Academy of Sciences - PNAS (12-11-2019)“…Recent work with prion diseases and synucleinopathies indicates that accurate diagnostic methods for protein-folding diseases can be based on the…”
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17
Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer's disease: Phase 3 study
Published in Alzheimer's & dementia (01-08-2015)“…Abstract Background Evaluation of brain β-amyloid by positron emission tomography (PET) imaging can assist in the diagnosis of Alzheimer disease (AD) and other…”
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Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains
Published in PLoS pathogens (01-06-2015)“…Prions propagate as multiple strains in a wide variety of mammalian species. The detection of all such strains by a single ultrasensitive assay such as Real…”
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Cryo-EM structures of prion protein filaments from Gerstmann–Sträussler–Scheinker disease
Published in Acta neuropathologica (01-09-2022)“…Prion protein (PrP) aggregation and formation of PrP amyloid (APrP) are central events in the pathogenesis of prion diseases. In the dominantly inherited prion…”
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Dominantly inherited prion protein cerebral amyloidoses - a modern view of Gerstmann-Sträussler-Scheinker
Published in Handbook of clinical neurology (2018)“…Among genetically determined neurodegenerative diseases, the dominantly inherited prion protein cerebral amyloidoses are characterized by deposition of amyloid…”
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