Search Results - "Ghetti, Bernardino"

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    Structures of filaments from Pick’s disease reveal a novel tau protein fold by Falcon, Benjamin, Zhang, Wenjuan, Murzin, Alexey G., Murshudov, Garib, Garringer, Holly J., Vidal, Ruben, Crowther, R. Anthony, Ghetti, Bernardino, Scheres, Sjors H. W., Goedert, Michel

    Published in Nature (London) (01-09-2018)
    “…The ordered assembly of tau protein into abnormal filamentous inclusions underlies many human neurodegenerative diseases 1 . Tau assemblies seem to spread…”
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    Structure of Tau filaments in Prion protein amyloidoses by Hallinan, Grace I., Hoq, Md Rejaul, Ghosh, Manali, Vago, Frank S., Fernandez, Anllely, Garringer, Holly J., Vidal, Ruben, Jiang, Wen, Ghetti, Bernardino

    Published in Acta neuropathologica (01-08-2021)
    “…In human neurodegenerative diseases associated with the intracellular aggregation of Tau protein, the ordered cores of Tau filaments adopt distinct folds…”
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    Astroglial tracer BU99008 detects multiple binding sites in Alzheimer’s disease brain by Kumar, Amit, Koistinen, Niina A., Malarte, Mona-Lisa, Nennesmo, Inger, Ingelsson, Martin, Ghetti, Bernardino, Lemoine, Laetitia, Nordberg, Agneta

    Published in Molecular psychiatry (01-10-2021)
    “…With reactive astrogliosis being established as one of the hallmarks of Alzheimer’s disease (AD), there is high interest in developing novel positron emission…”
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    Invited review: Frontotemporal dementia caused by microtubule-associated protein tau gene (MAPT) mutations: a chameleon for neuropathology and neuroimaging by Ghetti, Bernardino, Oblak, Adrian L., Boeve, Bradley F., Johnson, Keith A., Dickerson, Bradford C., Goedert, Michel

    Published in Neuropathology and applied neurobiology (01-02-2015)
    “…Hereditary frontotemporal dementia associated with mutations in the microtubule‐associated protein tau gene (MAPT) is a protean disorder. Three neuropathologic…”
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    Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607 by Shi, Yang, Murzin, Alexey G., Falcon, Benjamin, Epstein, Alexander, Machin, Jonathan, Tempest, Paul, Newell, Kathy L., Vidal, Ruben, Garringer, Holly J., Sahara, Naruhiko, Higuchi, Makoto, Ghetti, Bernardino, Jang, Ming-Kuei, Scheres, Sjors H. W., Goedert, Michel

    Published in Acta neuropathologica (01-05-2021)
    “…Tau and Aβ assemblies of Alzheimer’s disease (AD) can be visualized in living subjects using positron emission tomography (PET). Tau assemblies comprise paired…”
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    Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease by Kraus, Allison, Saijo, Eri, Metrick, Michael A., Newell, Kathy, Sigurdson, Christina J., Zanusso, Gianluigi, Ghetti, Bernardino, Caughey, Byron

    Published in Acta neuropathologica (01-04-2019)
    “…Alzheimer disease (AD) and chronic traumatic encephalopathy (CTE) involve the abnormal accumulation in the brain of filaments composed of both three-repeat…”
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    Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC by Groveman, Bradley R, Orrù, Christina D, Hughson, Andrew G, Raymond, Lynne D, Zanusso, Gianluigi, Ghetti, Bernardino, Campbell, Katrina J, Safar, Jiri, Galasko, Douglas, Caughey, Byron

    Published in Acta neuropathologica communications (09-02-2018)
    “…The diagnosis and treatment of synucleinopathies such as Parkinson disease and dementia with Lewy bodies would be aided by the availability of assays for the…”
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    Ultrasensitive and selective detection of 3-repeat tau seeding activity in Pick disease brain and cerebrospinal fluid by Saijo, Eri, Ghetti, Bernardino, Zanusso, Gianluigi, Oblak, Adrian, Furman, Jennifer L., Diamond, Marc I., Kraus, Allison, Caughey, Byron

    Published in Acta neuropathologica (01-05-2017)
    “…The diagnosis and treatment of diseases involving tau-based pathology such as Alzheimer disease and certain frontotemporal dementias is hampered by the…”
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    Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains by Orrú, Christina D, Groveman, Bradley R, Raymond, Lynne D, Hughson, Andrew G, Nonno, Romolo, Zou, Wenquan, Ghetti, Bernardino, Gambetti, Pierluigi, Caughey, Byron

    Published in PLoS pathogens (01-06-2015)
    “…Prions propagate as multiple strains in a wide variety of mammalian species. The detection of all such strains by a single ultrasensitive assay such as Real…”
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    Cryo-EM structures of prion protein filaments from Gerstmann–Sträussler–Scheinker disease by Hallinan, Grace I., Ozcan, Kadir A., Hoq, Md Rejaul, Cracco, Laura, Vago, Frank S., Bharath, Sakshibeedu R., Li, Daoyi, Jacobsen, Max, Doud, Emma H., Mosley, Amber L., Fernandez, Anllely, Garringer, Holly J., Jiang, Wen, Ghetti, Bernardino, Vidal, Ruben

    Published in Acta neuropathologica (01-09-2022)
    “…Prion protein (PrP) aggregation and formation of PrP amyloid (APrP) are central events in the pathogenesis of prion diseases. In the dominantly inherited prion…”
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    Dominantly inherited prion protein cerebral amyloidoses - a modern view of Gerstmann-Sträussler-Scheinker by Ghetti, Bernardino, Piccardo, Pedro, Zanusso, Gianluigi

    Published in Handbook of clinical neurology (2018)
    “…Among genetically determined neurodegenerative diseases, the dominantly inherited prion protein cerebral amyloidoses are characterized by deposition of amyloid…”
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