Search Results - "Ghetie, V"

Clinical evaluation of ricin A-chain immunotoxins in patients with Hodgkin’s lymphoma by Schnell, R., Borchmann, P., Staak, J. O., Schindler, J., Ghetie, V., Vitetta, E. S., Engert, A.

“…Background: Immunotoxins (ITs) consist of cell binding ligands coupled to toxins or their subunits. Hodgkin’s lymphoma (HL) is an excellent target for ITs…”
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Expression of functionally active FcRn and the differentiated bidirectional transport of IgG in human placental endothelial cells by Antohe, Felicia, Rădulescu, Luminiţa, Gafencu, Anca, Gheţie, Victor, Simionescu, Maya

“…The mechanism of selective transport of the immunoglobulins G from the placental stroma to the lumen of the fetal blood vessels has not been elucidated yet. It…”
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Delineation of the amino acid residues involved in transcytosis and catabolism of mouse IgG1 by Medesan, C, Matesoi, D, Radu, C, Ghetie, V, Ward, ES

“…The MHC class I-related receptor, FcRn, is involved in both the transcytosis of serum gamma-globulins (IgGs) and in regulating their serum persistence. The…”
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Treatment of SCID human B cell precursor ALL with anti-CD19 and anti-CD22 immunotoxins by HERRERA, L, YARBROUGH, S, GHETIE, V, AQUINO, D. B, VITETTA, E. S

“…The anti-CD19 (HD37-dgRTA) and anti-CD22 (RFB4-dgRTA) immunotoxins (ITs) are murine IgG(1) monoclonal antibodies (Mabs) conjugated to a deglycosylated ricin A…”
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Anti-CD19 immunotoxin enhances the activity of chemotherapy in severe combined immunodeficient mice with human pre-B acute lymphoblastic leukemia by Herrera, L., Stanciu-Herrera, C., Morgan, C., Ghetie, V., Vitetta, E. S.

“…The anti-CD19 immunotoxin (IT) (HD37-dgRTA) is effective in killing B-lineage leukemia cells and in curing severe combined immunodeficient mice with acute…”
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Treatment of refractory Hodgkin's lymphoma patients with an anti-CD25 ricin A-chain immunotoxin by SCHNELL, R, VITETTA, E, SCHINDLER, J, BORCHMANN, P, BARTH, S, GHETIE, V, HELL, K, DRILLICH, S, DIEHL, V, ENGERT, A

“…The anti-CD25 immunotoxin RFT5.dgA was constructed by coupling the monoclonal antibody RFT5 via a sterically hindered disulfide linker to deglycosylated ricin…”
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A phase I study of an anti-CD22-deglycosylated ricin A chain immunotoxin in the treatment of B-cell lymphomas resistant to conventional therapy by AMLOT, P. L, STONE, M. J, RAMILO, O, THORPE, P. E, UHR, J. W, VITETTA, E. S, CUNNINGHAM, D, FAY, J, NEWMAN, J, COLLINS, R, MAY, R, MCCARTHY, M, RICHARDSON, J, GHETIE, V

“…Twenty-six patients, whose B-cell lymphoma had relapsed after conventional therapies, were treated in a phase I dose escalation study with an immunotoxin…”
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Chemical construction of immunotoxins by GHETIE, Victor, VITETTA, Ellen S

“…Immunotoxins are chimeric proteins consisting of an antibody linked to a toxin. The antibodies most frequently used for the preparation of immunotoxins are…”
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Optimized clinical-scale culture conditions for ex vivo selective depletion of host-reactive donor lymphocytes: a strategy for GvHD prophylaxis in allogeneic PBSC transplantation by Solomon, S.R., Tran, T., Carter, C.S., Donnelly, S., Hensel, N., Schindler, J., Bahceci, E., Ghetie, V., Michálek, J., Mavroudis, D., Read, E.J., Vitetta, E.S., Barrett, A.J.

“…Ex vivo selective depletion (SD) is a strategy to prevent GvHD, in which host-reactive donor lymphocytes are selectively eliminated from a PBSC allograft while…”
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Clinical Trials with an Anti-CD25 Ricin A-Chain Experimental and Immunotoxin (RFT5-SMPT-dgA) in Hodgkin's Lymphoma by Schnell, R., Vitetta, E., Schindler, J., Barth, S., Winkler, U., Borchmann, P., Hansmann, M. L., Diehl, V., Ghetie, V., Engert, A.

“…Immunotoxins (ITs) consisting of a cell-binding component and a potent toxin were developed as a new class of biological anti-tumor agents to improve adjuvant…”
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Registration of TTU‐LRC Castor Germplasm with Reduced Levels of Ricin and RCA120 by Auld, D.L., Pinkerton, S.D., Boroda, E., Lombard, K.A., Murphy, C.K., Kenworthy, K.E., Becker, W.D., Rolfe, R.D., Ghetie, V.

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A phase I study of a combination of anti‐CD19 and anti‐CD22 immunotoxins (Combotox) in adult patients with refractory B‐lineage acute lymphoblastic leukaemia by Schindler, John, Gajavelli, Srikanth, Ravandi, Farhad, Shen, YuMin, Parekh, Samir, Braunchweig, Ira, Barta, Stefan, Ghetie, Victor, Vitetta, Ellen, Verma, Amit

“…Summary Novel agents are needed for patients with refractory and relapsed acute lymphoblastic leukaemia (ALL). Combotox is a 1:1 mixture of two immunotoxins…”
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The effector functions of immunoglobulins: implications for therapy by Ward, E S, Ghetie, V

“…The effector functions of immunoglobulins of the G class (IgGs) are essential for their effective use in therapy. The functions that operate following complex…”
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Multiple Roles for the Major Histocompatibility Complex Class I- Related Receptor FcRn by Ghetie, Victor, Ward, E. Sally

“…Multiple functions have recently been identified for the neonatal Fc receptor FcRn. In addition, a human homolog of the rodent forms of FcRn has been…”
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Immunotoxins for the treatment of B-cell lymphomas by Ghetie, M A, Ghetie, V, Vitetta, E S

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Differences in promiscuity for antibody–FcRn interactions across species: implications for therapeutic antibodies by Ober, Raimund J., Radu, Caius G., Ghetie, Victor, Ward, E. Sally

“…Preclinical tests of therapeutic antibodies are frequently carried out in mice to evaluate pharmacokinetics and efficacy. However, the observation that mouse…”
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Good science in the newly emerging European democracies by Ghetie, V

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Interactions of immunoglobulins outside the antigen-combining site by Nezlin, Roald, Ghetie, Victor

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The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of γ-globulin in humans by Firan, Mihail, Bawdon, Roger, Radu, Caius, Ober, Raimund J., Eaken, Darla, Antohe, Felicia, Ghetie, Victor, Ward, E. Sally

“…The transfer of maternal γ-globulin (IgG) provides the neonate with humoral immunity during early life. In humans, maternal IgG is transported across the…”
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Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans by Ward, E. Sally, Zhou, Jinchun, Ghetie, Victor, Ober, Raimund J.

“…IgG is the most abundant serum antibody and is an essential component of the humoral immune response. It is known that the ‘neonatal’ Fc receptor (FcRn) plays…”
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