Search Results - "Ghesquière, Bart"

Metabolism of stromal and immune cells in health and disease by Ghesquière, Bart, Wong, Brian W., Kuchnio, Anna, Carmeliet, Peter

“…This Review discusses stromal and immune cell metabolism and its implications for health and disease. Stromal and immune cells in disease This Review focuses…”
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Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase by Palmieri, Erika M., Gonzalez-Cotto, Marieli, Baseler, Walter A., Davies, Luke C., Ghesquière, Bart, Maio, Nunziata, Rice, Christopher M., Rouault, Tracey A., Cassel, Teresa, Higashi, Richard M., Lane, Andrew N., Fan, Teresa W.-M., Wink, David A., McVicar, Daniel W.

“…Profound metabolic changes are characteristic of macrophages during classical activation and have been implicated in this phenotype. Here we demonstrate that…”
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Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis by Wenes, Mathias, Shang, Min, Di Matteo, Mario, Goveia, Jermaine, Martín-Pérez, Rosa, Serneels, Jens, Prenen, Hans, Ghesquière, Bart, Carmeliet, Peter, Mazzone, Massimiliano

“…Hypoxic tumor-associated macrophages (TAMs) acquire angiogenic and immunosuppressive properties. Yet it remains unknown if metabolic changes influence these…”
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A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity by Knobloch, Marlen, Pilz, Gregor-Alexander, Ghesquière, Bart, Kovacs, Werner J., Wegleiter, Thomas, Moore, Darcie L., Hruzova, Martina, Zamboni, Nicola, Carmeliet, Peter, Jessberger, Sebastian

“…Hippocampal neurogenesis is important for certain forms of cognition, and failing neurogenesis has been implicated in neuropsychiatric diseases. The neurogenic…”
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Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy by Cantelmo, Anna Rita, Conradi, Lena-Christin, Brajic, Aleksandra, Goveia, Jermaine, Kalucka, Joanna, Pircher, Andreas, Chaturvedi, Pallavi, Hol, Johanna, Thienpont, Bernard, Teuwen, Laure-Anne, Schoors, Sandra, Boeckx, Bram, Vriens, Joris, Kuchnio, Anna, Veys, Koen, Cruys, Bert, Finotto, Lise, Treps, Lucas, Stav-Noraas, Tor Espen, Bifari, Francesco, Stapor, Peter, Decimo, Ilaria, Kampen, Kim, De Bock, Katrien, Haraldsen, Guttorm, Schoonjans, Luc, Rabelink, Ton, Eelen, Guy, Ghesquière, Bart, Rehman, Jalees, Lambrechts, Diether, Malik, Asrar B., Dewerchin, Mieke, Carmeliet, Peter

“…Abnormal tumor vessels promote metastasis and impair chemotherapy. Hence, tumor vessel normalization (TVN) is emerging as an anti-cancer treatment. Here, we…”
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Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis by Palmieri, Erika M., Menga, Alessio, Martín-Pérez, Rosa, Quinto, Annamaria, Riera-Domingo, Carla, De Tullio, Giacoma, Hooper, Douglas C., Lamers, Wouter H., Ghesquière, Bart, McVicar, Daniel W., Guarini, Attilio, Mazzone, Massimiliano, Castegna, Alessandra

“…Glutamine-synthetase (GS), the glutamine-synthesizing enzyme from glutamate, controls important events, including the release of inflammatory mediators,…”
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Role of glutamine and interlinked asparagine metabolism in vessel formation by Huang, Hongling, Vandekeere, Saar, Kalucka, Joanna, Bierhansl, Laura, Zecchin, Annalisa, Brüning, Ulrike, Visnagri, Asjad, Yuldasheva, Nadira, Goveia, Jermaine, Cruys, Bert, Brepoels, Katleen, Wyns, Sabine, Rayport, Stephen, Ghesquière, Bart, Vinckier, Stefan, Schoonjans, Luc, Cubbon, Richard, Dewerchin, Mieke, Eelen, Guy, Carmeliet, Peter

“…Endothelial cell (EC) metabolism is emerging as a regulator of angiogenesis, but the precise role of glutamine metabolism in ECs is unknown. Here, we show that…”
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Metabolites released from apoptotic cells act as tissue messengers by Medina, Christopher B., Mehrotra, Parul, Arandjelovic, Sanja, Perry, Justin S. A., Guo, Yizhan, Morioka, Sho, Barron, Brady, Walk, Scott F., Ghesquière, Bart, Krupnick, Alexander S., Lorenz, Ulrike, Ravichandran, Kodi S.

“…Caspase-dependent apoptosis accounts for approximately 90% of homeostatic cell turnover in the body 1 , and regulates inflammation, cell proliferation, and…”
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Fatty acid carbon is essential for dNTP synthesis in endothelial cells by Schoors, Sandra, Bruning, Ulrike, Missiaen, Rindert, Queiroz, Karla C. S., Borgers, Gitte, Elia, Ilaria, Zecchin, Annalisa, Cantelmo, Anna Rita, Christen, Stefan, Goveia, Jermaine, Heggermont, Ward, Goddé, Lucica, Vinckier, Stefan, Van Veldhoven, Paul P., Eelen, Guy, Schoonjans, Luc, Gerhardt, Holger, Dewerchin, Mieke, Baes, Myriam, De Bock, Katrien, Ghesquière, Bart, Lunt, Sophia Y., Fendt, Sarah-Maria, Carmeliet, Peter

“…The metabolism of endothelial cells during vessel sprouting remains poorly studied. Here we report that endothelial loss of CPT1A, a rate-limiting enzyme of…”
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Tumor Vessel Normalization by Chloroquine Independent of Autophagy by Maes, Hannelore, Kuchnio, Anna, Peric, Aleksandar, Moens, Stijn, Nys, Kris, De Bock, Katrien, Quaegebeur, Annelies, Schoors, Sandra, Georgiadou, Maria, Wouters, Jasper, Vinckier, Stefan, Vankelecom, Hugo, Garmyn, Marjan, Vion, Anne-Clémence, Radtke, Freddy, Boulanger, Chantal, Gerhardt, Holger, Dejana, Elisabetta, Dewerchin, Mieke, Ghesquière, Bart, Annaert, Wim, Agostinis, Patrizia, Carmeliet, Peter

“…Chloroquine (CQ) has been evaluated as an autophagy blocker for cancer treatment, but it is unknown if it acts solely by inhibiting cancer cell autophagy. We…”
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Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells by Vandekeere, Saar, Dubois, Charlotte, Kalucka, Joanna, Sullivan, Mark R., García-Caballero, Melissa, Goveia, Jermaine, Chen, Rongyuan, Diehl, Frances F., Bar-Lev, Libat, Souffreau, Joris, Pircher, Andreas, Kumar, Saran, Vinckier, Stefan, Hirabayashi, Yoshio, Furuya, Shigeki, Schoonjans, Luc, Eelen, Guy, Ghesquière, Bart, Keshet, Eli, Li, Xuri, Vander Heiden, Matthew G., Dewerchin, Mieke, Carmeliet, Peter

“…The role of phosphoglycerate dehydrogenase (PHGDH), a key enzyme of the serine synthesis pathway (SSP), in endothelial cells (ECs) remains poorly…”
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ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress by Vrijsen, Stephanie, Besora-Casals, Laura, van Veen, Sarah, Zielich, Jeffrey, Van den Haute, Chris, Hamouda, Norin Nabil, Fischer, Christian, Ghesquière, Bart, Tournev, Ivailo, Agostinis, Patrizia, Baekelandt, Veerle, Eggermont, Jan, Lambie, Eric, Martin, Shaun, Vangheluwe, Peter

“…Recessive loss-of-function mutations in ATP13A2 (PARK9) are associated with a spectrum of neurodegenerative disorders, including Parkinson’s disease (PD). We…”
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Codon-specific translation reprogramming promotes resistance to targeted therapy by Rapino, Francesca, Delaunay, Sylvain, Rambow, Florian, Zhou, Zhaoli, Tharun, Lars, De Tullio, Pascal, Sin, Olga, Shostak, Kateryna, Schmitz, Sebastian, Piepers, Jolanda, Ghesquière, Bart, Karim, Latifa, Charloteaux, Benoit, Jamart, Diane, Florin, Alexandra, Lambert, Charles, Rorive, Andrée, Jerusalem, Guy, Leucci, Eleonora, Dewaele, Michael, Vooijs, Marc, Leidel, Sebastian A., Georges, Michel, Voz, Marianne, Peers, Bernard, Büttner, Reinhard, Marine, Jean-Christophe, Chariot, Alain, Close, Pierre

“…Reprogramming of mRNA translation has a key role in cancer development and drug resistance 1 . However, the molecular mechanisms that are involved in this…”
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ATP13A2 deficiency disrupts lysosomal polyamine export by van Veen, Sarah, Martin, Shaun, Van den Haute, Chris, Benoy, Veronick, Lyons, Joseph, Vanhoutte, Roeland, Kahler, Jan Pascal, Decuypere, Jean-Paul, Gelders, Géraldine, Lambie, Eric, Zielich, Jeffrey, Swinnen, Johannes V., Annaert, Wim, Agostinis, Patrizia, Ghesquière, Bart, Verhelst, Steven, Baekelandt, Veerle, Eggermont, Jan, Vangheluwe, Peter

“…ATP13A2 (PARK9) is a late endolysosomal transporter that is genetically implicated in a spectrum of neurodegenerative disorders, including Kufor-Rakeb…”
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Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation by Bruning, Ulrike, Morales-Rodriguez, Francisco, Kalucka, Joanna, Goveia, Jermaine, Taverna, Federico, Queiroz, Karla C.S., Dubois, Charlotte, Cantelmo, Anna Rita, Chen, Rongyuan, Loroch, Stefan, Timmerman, Evy, Caixeta, Vanessa, Bloch, Katarzyna, Conradi, Lena-Christin, Treps, Lucas, Staes, An, Gevaert, Kris, Tee, Andrew, Dewerchin, Mieke, Semenkovich, Clay F., Impens, Francis, Schilling, Birgit, Verdin, Eric, Swinnen, Johannes V., Meier, Jordan L., Kulkarni, Rhushikesh A., Sickmann, Albert, Ghesquière, Bart, Schoonjans, Luc, Li, Xuri, Mazzone, Massimiliano, Carmeliet, Peter

“…The role of fatty acid synthesis in endothelial cells (ECs) remains incompletely characterized. We report that fatty acid synthase knockdown (FASNKD) in ECs…”
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Proteomics methods to study methionine oxidation by Ghesquière, Bart, Gevaert, Kris

“…The oxidation and consequent reduction of protein‐bound methionine residues is of great interest in understanding different aspects of how oxidative stress…”
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Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis by Meçe, Odeta, Houbaert, Diede, Sassano, Maria-Livia, Durré, Tania, Maes, Hannelore, Schaaf, Marco, More, Sanket, Ganne, Maarten, García-Caballero, Melissa, Borri, Mila, Verhoeven, Jelle, Agrawal, Madhur, Jacobs, Kathryn, Bergers, Gabriele, Blacher, Silvia, Ghesquière, Bart, Dewerchin, Mieke, Swinnen, Johan V., Vinckier, Stefan, Soengas, María S., Carmeliet, Peter, Noël, Agnès, Agostinis, Patrizia

“…Autophagy has vasculoprotective roles, but whether and how it regulates lymphatic endothelial cells (LEC) homeostasis and lymphangiogenesis is unknown. Here,…”
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Partial and Transient Reduction of Glycolysis by PFKFB3 Blockade Reduces Pathological Angiogenesis by Schoors, Sandra, De Bock, Katrien, Cantelmo, Anna Rita, Georgiadou, Maria, Ghesquière, Bart, Cauwenberghs, Sandra, Kuchnio, Anna, Wong, Brian W., Quaegebeur, Annelies, Goveia, Jermaine, Bifari, Francesco, Wang, Xingwu, Blanco, Raquel, Tembuyser, Bieke, Cornelissen, Ivo, Bouché, Ann, Vinckier, Stefan, Diaz-Moralli, Santiago, Gerhardt, Holger, Telang, Sucheta, Cascante, Marta, Chesney, Jason, Dewerchin, Mieke, Carmeliet, Peter

“…Strategies targeting pathological angiogenesis have focused primarily on blocking vascular endothelial growth factor (VEGF), but resistance and insufficient…”
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Macrophage-derived glutamine boosts satellite cells and muscle regeneration by Shang, Min, Cappellesso, Federica, Amorim, Ricardo, Serneels, Jens, Virga, Federico, Eelen, Guy, Carobbio, Stefania, Rincon, Melvin Y., Maechler, Pierre, De Bock, Katrien, Ho, Ping-Chih, Sandri, Marco, Ghesquière, Bart, Carmeliet, Peter, Di Matteo, Mario, Berardi, Emanuele, Mazzone, Massimiliano

“…Muscle regeneration is sustained by infiltrating macrophages and the consequent activation of satellite cells 1 – 4 . Macrophages and satellite cells…”
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The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming by Hochrein, Sophia M., Wu, Hao, Eckstein, Miriam, Arrigoni, Laura, Herman, Josip S., Schumacher, Fabian, Gerecke, Christian, Rosenfeldt, Mathias, Grün, Dominic, Kleuser, Burkhard, Gasteiger, Georg, Kastenmüller, Wolfgang, Ghesquière, Bart, Van den Bossche, Jan, Abel, E. Dale, Vaeth, Martin

“…Metabolic reprogramming is a hallmark of activated T cells. The switch from oxidative phosphorylation to aerobic glycolysis provides energy and intermediary…”
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