Search Results - "Gherardin, Nicholas A."

The biology and functional importance of MAIT cells by Godfrey, Dale I., Koay, Hui-Fern, McCluskey, James, Gherardin, Nicholas A.

“…In recent years, a population of unconventional T cells called ‘mucosal-associated invariant T cells’ (MAIT cells) has captured the attention of immunologists…”
Get full text

Human blood MAIT cell subsets defined using MR1 tetramers by Gherardin, Nicholas A, Souter, Michael NT, Koay, Hui‐Fern, Mangas, Kirstie M, Seemann, Torsten, Stinear, Timothy P, Eckle, Sidonia BG, Berzins, Stuart P, d'Udekem, Yves, Konstantinov, Igor E, Fairlie, David P, Ritchie, David S, Neeson, Paul J, Pellicci, Daniel G, Uldrich, Adam P, McCluskey, James, Godfrey, Dale I

“…Mucosal‐associated invariant T (MAIT) cells represent up to 10% of circulating human T cells. They are usually defined using combinations of…”
Get full text

Diverse MR1-restricted T cells in mice and humans by Koay, Hui-Fern, Gherardin, Nicholas A., Xu, Calvin, Seneviratna, Rebecca, Zhao, Zhe, Chen, Zhenjun, Fairlie, David P., McCluskey, James, Pellicci, Daniel G., Uldrich, Adam P., Godfrey, Dale I.

“…Mucosal-associated invariant T (MAIT) cells express an invariant TRAV1/TRAJ33 TCR-α chain and are restricted to the MHC-I-like molecule, MR1. Whether MAIT cell…”
Get full text

Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition by Gherardin, Nicholas A., Keller, Andrew N., Woolley, Rachel E., Le Nours, Jérôme, Ritchie, David S., Neeson, Paul J., Birkinshaw, Richard W., Eckle, Sidonia B.G., Waddington, John N., Liu, Ligong, Fairlie, David P., Uldrich, Adam P., Pellicci, Daniel G., McCluskey, James, Godfrey, Dale I., Rossjohn, Jamie

“…A characteristic of mucosal-associated invariant T (MAIT) cells is the expression of TRAV1-2+ T cell receptors (TCRs) that are activated by riboflavin…”
Get full text

Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed multiple myeloma by Gherardin, Nicholas A., Loh, Liyen, Admojo, Lorenztino, Davenport, Alexander J., Richardson, Kelden, Rogers, Amy, Darcy, Phillip K., Jenkins, Misty R., Prince, H. Miles, Harrison, Simon J., Quach, Hang, Fairlie, David P., Kedzierska, Katherine, McCluskey, James, Uldrich, Adam P., Neeson, Paul J., Ritchie, David S., Godfrey, Dale I.

“…Mucosal-associated invariant T (MAIT) cells are T cells that recognise vitamin-B derivative Ag presented by the MHC-related-protein 1 (MR1) antigen-presenting…”
Get full text

Direct recognition of an intact foreign protein by an αβ T cell receptor by Almeida, Catarina F., Gully, Benjamin S., Jones, Claerwen M., Kedzierski, Lukasz, Gunasinghe, Sachith D., Rice, Michael T., Berry, Richard, Gherardin, Nicholas A., Nguyen, Trang T., Mok, Yee-Foong, Reijneveld, Josephine F., Moody, D. Branch, Van Rhijn, Ildiko, La Gruta, Nicole L., Uldrich, Adam P., Rossjohn, Jamie, Godfrey, Dale I.

“…αβ T cell receptors (αβTCRs) co-recognise antigens when bound to Major Histocompatibility Complex (MHC) or MHC class I-like molecules. Additionally, some…”
Get full text

Intracellular radar: Understanding γδ T cell immune surveillance and implications for clinical strategies in oncology by Cherry, Anne B. C., Gherardin, Nicholas A., Sikder, Hafiz I.

“…T cells play a key role in anticancer immunity, with responses mediated through a diversity of αβ or γδ T cell receptors. Although αβ and γδ T cells stem from…”
Get full text

Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens by Le Nours, Jérôme, Praveena, T., Pellicci, Daniel G., Gherardin, Nicholas A., Ross, Fiona J., Lim, Ricky T., Besra, Gurdyal S., Keshipeddy, Santosh, Richardson, Stewart K., Howell, Amy R., Gras, Stephanie, Godfrey, Dale I., Rossjohn, Jamie, Uldrich, Adam P.

“…Crucial to Natural Killer T (NKT) cell function is the interaction between their T-cell receptor (TCR) and CD1d-antigen complex. However, the diversity of the…”
Get full text

Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2 by Wines, Bruce D, Kurtovic, Liriye, Trist, Halina M, Esparon, Sandra, Lopez, Ester, Chappin, Klasina, Chan, Li-Jin, Mordant, Francesca L, Lee, Wen Shi, Gherardin, Nicholas A, Patel, Sheila K, Hartley, Gemma E, Pymm, Phillip, Cooney, James P, Beeson, James G, Godfrey, Dale I, Burrell, Louise M, van Zelm, Menno C, Wheatley, Adam K, Chung, Amy W, Tham, Wai-Hong, Subbarao, Kanta, Kent, Stephen J, Hogarth, P Mark

“…Joining a function-enhanced Fc-portion of human IgG to the SARS-CoV-2 entry receptor ACE2 produces an antiviral decoy with strain transcending virus…”
Get full text

Corrigendum: Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2 by Wines, Bruce D, Kurtovic, Liriye, Trist, Halina M, Esparon, Sandra, Lopez, Ester, Chappin, Klasina, Chan, Li-Jin, Mordant, Francesca L, Lee, Wen Shi, Gherardin, Nicholas A, Patel, Sheila K, Hartley, Gemma E, Pymm, Phillip, Cooney, James P, Beeson, James G, Godfrey, Dale I, Burrell, Louise M, van Zelm, Menno C, Wheatley, Adam K, Chung, Amy W, Tham, Wai-Hong, Subbarao, Kanta, Kent, Stephen J, Hogarth, P Mark

“…[This corrects the article .]…”
Get full text

Simultaneous evaluation of antibodies that inhibit SARS-CoV-2 variants via multiplex assay by Lopez, Ester, Haycroft, Ebene R., Adair, Amy, Mordant, Francesca L., O’Neill, Matthew T., Pymm, Phillip, Redmond, Samuel J., Lee, Wen Shi, Gherardin, Nicholas A., Wheatley, Adam K., Juno, Jennifer A., Selva, Kevin J., Davis, Samantha K., Grimley, Samantha L., Harty, Leigh, Purcell, Damian F.J., Subbarao, Kanta, Godfrey, Dale I., Kent, Stephen J., Tham, Wai-Hong, Chung, Amy W.

“…The SARS-CoV-2 receptor binding domain (RBD) is both the principal target of neutralizing antibodies and one of the most rapidly evolving domains, which can…”
Get full text

Heterologous SARS‐CoV‐2 IgA neutralising antibody responses in convalescent plasma by Davis, Samantha K, Selva, Kevin John, Lopez, Ester, Haycroft, Ebene R, Lee, Wen Shi, Wheatley, Adam K, Juno, Jennifer A, Adair, Amy, Pymm, Phillip, Redmond, Samuel J, Gherardin, Nicholas A, Godfrey, Dale I, Tham, Wai‐Hong, Kent, Stephen J, Chung, Amy W

“…Objectives Following infection with SARS‐CoV‐2, virus‐specific antibodies are generated, which can both neutralise virions and clear infection via Fc effector…”
Get full text

Biparatopic nanobodies targeting the receptor binding domain efficiently neutralize SARS-CoV-2 by Pymm, Phillip, Redmond, Samuel J., Dolezal, Olan, Mordant, Francesca, Lopez, Ester, Cooney, James P., Davidson, Kathryn C., Haycroft, Ebene R., Tan, Chee Wah, Seneviratna, Rebecca, Grimley, Samantha L., Purcell, Damian F.J., Kent, Stephen J., Wheatley, Adam K., Wang, Lin-Fa, Leis, Andrew, Glukhova, Alisa, Pellegrini, Marc, Chung, Amy W., Subbarao, Kanta, Uldrich, Adam P., Tham, Wai-Hong, Godfrey, Dale I., Gherardin, Nicholas A.

“…The development of therapeutics to prevent or treat COVID-19 remains an area of intense focus. Protein biologics, including monoclonal antibodies and…”
Get full text

The Diverse Family of MR1-Restricted T Cells by Gherardin, Nicholas A, McCluskey, James, Rossjohn, Jamie, Godfrey, Dale I

“…Mucosal-associated invariant T (MAIT) cells are characterized by a semi-invariant TCR that recognizes vitamin B metabolite Ags presented by the MHC-related…”
Get full text

Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells by Rigau, Marc, Ostrouska, Simone, Fulford, Thomas S, Johnson, Darryl N, Woods, Katherine, Ruan, Zheng, McWilliam, Hamish E G, Hudson, Christopher, Tutuka, Candani, Wheatley, Adam K, Kent, Stephen J, Villadangos, Jose A, Pal, Bhupinder, Kurts, Christian, Simmonds, Jason, Pelzing, Matthias, Nash, Andrew D, Hammet, Andrew, Verhagen, Anne M, Vairo, Gino, Maraskovsky, Eugene, Panousis, Con, Gherardin, Nicholas A, Cebon, Jonathan, Godfrey, Dale I, Behren, Andreas, Uldrich, Adam P

“…Gamma delta (γδ) T cells are essential to protective immunity. In humans, most γδ T cells express Vγ9Vδ2 T cell receptors (TCRs) that respond to…”
Get full text

Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19 by Juno, Jennifer A., Tan, Hyon-Xhi, Lee, Wen Shi, Reynaldi, Arnold, Kelly, Hannah G., Wragg, Kathleen, Esterbauer, Robyn, Kent, Helen E., Batten, C. Jane, Mordant, Francesca L., Gherardin, Nicholas A., Pymm, Phillip, Dietrich, Melanie H., Scott, Nichollas E., Tham, Wai-Hong, Godfrey, Dale I., Subbarao, Kanta, Davenport, Miles P., Kent, Stephen J., Wheatley, Adam K.

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has dramatically expedited global vaccine development efforts 1 – 3 , most targeting…”
Get full text

CD1 and MR1: An update after a long-awaited reunion by Gherardin, Nicholas A., Legoux, Francois, Consonni, Michela, Paget, Christophe

“…CD1 molecules and the MHC-related protein 1 (MR1) present lipid and small molecule antigens, respectively, for T cell surveillance. The biology of these…”
Get full text

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage by Koay, Hui-Fern, Gherardin, Nicholas A, Enders, Anselm, Loh, Liyen, Mackay, Laura K, Almeida, Catarina F, Russ, Brendan E, Nold-Petry, Claudia A, Nold, Marcel F, Bedoui, Sammy, Chen, Zhenjun, Corbett, Alexandra J, Eckle, Sidonia B G, Meehan, Bronwyn, d'Udekem, Yves, Konstantinov, Igor E, Lappas, Martha, Liu, Ligong, Goodnow, Chris C, Fairlie, David P, Rossjohn, Jamie, Chong, Mark M, Kedzierska, Katherine, Berzins, Stuart P, Belz, Gabrielle T, McCluskey, James, Uldrich, Adam P, Godfrey, Dale I, Pellicci, Daniel G

“…Godfrey, Pellicci and colleagues define the developmental stages and checkpoints for the development of mucosal-associated invariant T cells in humans and…”
Get full text

CD1d-lipid antigen recognition by the γδ TCR by Uldrich, Adam P, Le Nours, Jérôme, Pellicci, Daniel G, Gherardin, Nicholas A, McPherson, Kirsty G, Lim, Ricky T, Patel, Onisha, Beddoe, Travis, Gras, Stephanie, Rossjohn, Jamie, Godfrey, Dale I

“…How γδ TCRs bind antigen presented by antigen-presenting molecules remains unclear. Godfrey and colleagues describe a population of human γδ T cells that…”
Get full text

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells by Reantragoon, Rangsima, Corbett, Alexandra J, Sakala, Isaac G, Gherardin, Nicholas A, Furness, John B, Chen, Zhenjun, Eckle, Sidonia B G, Uldrich, Adam P, Birkinshaw, Richard W, Patel, Onisha, Kostenko, Lyudmila, Meehan, Bronwyn, Kedzierska, Katherine, Liu, Ligong, Fairlie, David P, Hansen, Ted H, Godfrey, Dale I, Rossjohn, Jamie, McCluskey, James, Kjer-Nielsen, Lars

“…Mucosal-associated invariant T cells (MAIT cells) express a semi-invariant T cell receptor (TCR) α-chain, TRAV1-2-TRAJ33, and are activated by vitamin B…”
Get full text