Search Results - "Gherardi, E"

Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding by Sigurdardottir, A G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D, Ascher, D B, Blundell, T L, Gherardi, E

“…The growth/motility factor hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, the tyrosine kinase MET, constitute a signalling system essential…”
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Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors by Kemp, L E, Mulloy, B, Gherardi, E

“…The receptor tyrosine kinase Met and its ligand HGF/SF (hepatocyte growth factor/scatter factor) are essential in the signalling pathways required for…”
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Insights into the Structure/Function of Hepatocyte Growth Factor/Scatter Factor from Studies with Individual Domains by Holmes, O., Pillozzi, S., Deakin, J.A., Carafoli, F., Kemp, L., Butler, P.J.G., Lyon, M., Gherardi, E.

“…Hepatocyte growth factor/scatter factor (HGF/SF), the ligand for the receptor tyrosine kinase encoded by the c-Met proto-oncogene, is a multidomain protein…”
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The structural repertoire of the human V kappa domain by Tomlinson, I. M., Cox, J. P., Gherardi, E., Lesk, A. M., Chothia, C.

“…In humans, the gene for the V kappa domain is produced by the recombination of one of 40 functional V kappa segments and one of five functional J kappa…”
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Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement by Gherardi, E, Gray, J, Stoker, M, Perryman, M, Furlong, R

“…Scatter factor is a fibroblast-derived protein that causes separation of contiguous epithelial cells and increased local mobility of unanchored cells. Highly…”
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Roles of Hepatocyte Growth Factor/Scatter Factor and the Met Receptor in the Early Development of the Metanephros by Woolf, Adrian S., Kolatsi-Joannou, Maria, Hardman, Patricia, Andermarcher, Elisabetta, Moorby, Catriona, Fine, Leon G., Jat, Parmjit S., Noble, Mark D., Gherardi, Ermanno

“…Several lines of evidence suggest that hepatocyte growth factor/scatter factor (HGF/SF), a soluble protein secreted by embryo fibroblasts and several…”
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Molecular evolution and domain structure of plasminogen‐related growth factors (HGF/SF and HGF1/MSP) by Donate, Luis Enrique, Srinivasan, N., Sowdhamini, R., Gherardi, Ermanno, Blundell, Tom L., Aparicio, Samuel

“…Plasminogen‐related growth factors, a new family of polypeptide growth factors with the basic domain organization and mechanism of activation of the blood…”
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A role for HGF/SF in neural induction and its expression in Hensen's node during gastrulation by Streit, A, Stern, C D, Théry, C, Ireland, G W, Aparicio, S, Sharpe, M J, Gherardi, E

“…It was previously shown (Roberts, C., Platt, N., Streit, A., Schachner, M. and Stern, C. D. (1991) Development 112, 959–970) that grafts of Hensen's node…”
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Met, metastasis, motility and more by Vande Woude, George F, Birchmeier, Carmen, Gherardi, Ermanno, Birchmeier, Walter

“…Hepatocyte growth factor/scatter factor and its receptor, the tyrosine kinase Met, arose late in evolution and are unique to vertebrates. In spite of this, Met…”
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Growth factors and cell movement by Gherardi, E

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Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase by Birchmeier, Carmen, Gherardi, Ermanno

“…A number of developmental processes that involve cell migration, growth or morphogenesis depend on extracellular signals. A molecule that provides such…”
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Topography of apolipoprotein B in subcellular fractions of rabbit liver probed with a panel of monoclonal antibodies by WILKINSON, J, HIGGINS, J. A, GROOT, P, GHERARDI, E, BOWYER, D

“…We have used a panel of anti-rabbit apolipoprotein B monoclonal antibodies in a competitive ELISA to probe the availability of apoB in rough endoplasmic…”
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Mutation and Selection During the Secondary Response to 2-Phenyloxazolone by Rada, Cristina, Gupta, Satish K., Gherardi, Ermanno, Milstein, Cesar

“…The most characteristic feature of the mouse antibody response to the hapten 2-phenyloxazolone is the recurrent expression of the light-chain variable region…”
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Universal cloning and direct sequencing of rearranged antibody V genes using C region primers, biotin-captured cDNA and one-side PCR by Heinrichs, A., Milstein, C., Gherardi, E.

“…Polymerase chain reaction (PCR) cloning has greatly facilitated the cloning of heavy and light chain genes from B cells and hybridomas and has been critical…”
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Epithelial scatter factor and development of the chick embryonic axis by STERN, C. D, IRELAND, G. W, HERRICK, S. E, GHERARDI, E, GRAY, J, PERRYMAN, M, STOKER, M

“…Scatter factor, a recently characterised protein secreted by certain embryonic fibroblasts, affects cultured epithelial by increasing cell motility, the…”
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Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB by Niemann, Hartmut H, Jäger, Volker, Butler, P Jonathan G, van den Heuvel, Joop, Schmidt, Sabine, Ferraris, Davide, Gherardi, Ermanno, Heinz, Dirk W

“…The tyrosine kinase Met, the product of the c-met proto-oncogene and the receptor for hepatocyte growth factor/scatter factor (HGF/SF), mediates signals…”
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Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET bindingElectronic supplementary information (ESI) available: Description of fragment library screening and data analysis, compound soaking, X-ray data collection and processing, molecular docking and biological assays. Crystallographic and refinement statistics. See DOI: 10.1039/c5sc02155c by Sigurdardottir, A. G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D, Ascher, D. B, Blundell, T. L, Gherardi, E

“…The growth/motility factor hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, the tyrosine kinase MET, constitute a signalling system essential…”
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The effect of high-frequency random mutagenesis on in vitro protein evolution: a study on TEM-1 beta-lactamase by Zaccolo, M, Gherardi, E

“…For a number of years a major limitation in genetic analysis of protein function has been the inability to introduce multiple substitutions at distant sites…”
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Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding† †Electronic supplementary information (ESI) available: Description of fragment library screening and data analysis, compound soaking, X-ray data collection and processing, molecular docking and biological assays. Crystallographic and refinement statistics. See DOI: 10.1039/c5sc02155c by Sigurdardottir, A. G., Winter, A., Sobkowicz, A., Fragai, M., Chirgadze, D., Ascher, D. B., Blundell, T. L., Gherardi, E.

“…Targeting the lysine-binding pocket of the first kringle domain of HGF/SF using a fragment-based approach identified new chemical entities that can inhibit MET…”
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A single-step procedure for cloning and selection of antibody-secreting hybridomas by Gherardi, E, Pannell, R, Milstein, C

“…A procedure is described which permits high-yield direct cloning of newly established hybridomas on STO fibroblast feeders in soft agarose. Several thousand…”
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