Search Results - "Ghebeh, Hazem"

PD-L1 promotes OCT4 and Nanog expression in breast cancer stem cells by sustaining PI3K/AKT pathway activation by Almozyan, Sheema, Colak, Dilek, Mansour, Fatmah, Alaiya, Ayodele, Al-Harazi, Olfat, Qattan, Amal, Al-Mohanna, Falah, Al-Alwan, Monther, Ghebeh, Hazem

“…The expression of PD-L1 in breast cancer is associated with estrogen receptor negativity, chemoresistance and epithelial-to-mesenchymal transition (EMT), all…”
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Bidirectional crosstalk between PD-L1 expression and epithelial to mesenchymal transition: significance in claudin-low breast cancer cells by Alsuliman, Abdullah, Colak, Dilek, Al-Harazi, Olfat, Fitwi, Hanaa, Tulbah, Asma, Al-Tweigeri, Taher, Al-Alwan, Monther, Ghebeh, Hazem

“…The T-cell inhibitory molecule PD-L1 (B7-H1, CD274) is expressed on tumor cells of a subset of breast cancer patients. However, the mechanism that regulates…”
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Weekly Paclitaxel given concurrently with Durvalumab has a favorable safety profile in triple-negative metastatic breast cancer by Ghebeh, Hazem, Al-Sayed, Adher, Eiada, Riham, Cabangon, Leilani, Ajarim, Dahish, Suleman, Kausar, Tulbah, Asma, Al-Tweigeri, Taher

“…Therapeutic anti-PD-L1 antibodies are safe as a monotherapy, albeit with minimal efficacy in triple-negative breast cancer (TNBC). This trial aimed to test the…”
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PD-L1 is overexpressed on breast cancer stem cells through notch3/mTOR axis by Mansour, Fatmah A., Al-Mazrou, Amer, Al-Mohanna, Falah, Al-Alwan, Monther, Ghebeh, Hazem

“…The T-cell inhibitory molecule PD-L1 is expressed on a fraction of breast cancer cells. The distribution of PD-L1 on the different subpopulations of breast…”
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Fascin Is Critical for the Maintenance of Breast Cancer Stem Cell Pool Predominantly via the Activation of the Notch Self‐Renewal Pathway by Barnawi, Rayanah, Al‐Khaldi, Samiyah, Majed Sleiman, Ghida, Sarkar, Abdullah, Al‐Dhfyan, Abdullah, Al‐Mohanna, Falah, Ghebeh, Hazem, Al‐Alwan, Monther

“…An emerging dogma shows that tumors are initiated and maintained by a subpopulation of cancer cells that hijack some stem cell features and thus referred to as…”
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Fascin is a key regulator of breast cancer invasion that acts via the modification of metastasis-associated molecules by Al-Alwan, Monther, Olabi, Safiah, Ghebeh, Hazem, Barhoush, Eman, Tulbah, Asma, Al-Tweigeri, Taher, Ajarim, Dahish, Adra, Chaker

“…The actin-bundling protein, fascin, is a member of the cytoskeletal protein family that has restricted expression in specialized normal cells. However, many…”
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FOXP3+ Tregs and B7-H1+/PD-1+ T lymphocytes co-infiltrate the tumor tissues of high-risk breast cancer patients: Implication for immunotherapy by Ghebeh, Hazem, Barhoush, Eman, Tulbah, Asma, Elkum, Naser, Al-Tweigeri, Taher, Dermime, Said

“…Recent studies have demonstrated a direct involvement of B7-H1, PD-1 and FOXP3 molecules in the immune escape of cancer. B7-H1 is an inhibitory molecule that…”
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CD3+T-lymphocyte infiltration is an independent prognostic factor for advanced nasopharyngeal carcinoma by Al-Rajhi, Nasser, Soudy, Hussein, Ahmed, Shoaib A, Elhassan, Tusneem, Mohammed, Shamayel F, Khoja, Hatim A, Ghebeh, Hazem

“…Locally advanced nasopharyngeal carcinoma (LA-NPC) is a relatively rare disease in the west but more common in East Asia and areas of the Middle East like…”
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Fascin Activates β-Catenin Signaling and Promotes Breast Cancer Stem Cell Function Mainly Through Focal Adhesion Kinase (FAK): Relation With Disease Progression by Barnawi, Rayanah, Al-Khaldi, Samiyah, Bakheet, Tala, Fallatah, Mohannad, Alaiya, Ayodele, Ghebeh, Hazem, Al-Alwan, Monther

“…Cancer stem cells (CSCs), a rare population of tumor cells with high self-renewability potential, have gained increasing attention due to their contribution to…”
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Comparative Analysis of Breast Cancer Metabolomes Highlights Fascin's Central Role in Regulating Key Pathways Related to Disease Progression by AlMalki, Reem H, Al-Nasrallah, Huda K, Aldossry, Alanoud, Barnawi, Rayanah, Al-Khaldi, Samiyah, Almozyan, Sheema, Al-Ansari, Mysoon M, Ghebeh, Hazem, Abdel Rahman, Anas M, Al-Alwan, Monther

“…Omics technologies provide useful tools for the identification of novel biomarkers in many diseases, including breast cancer, which is the most diagnosed…”
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Novel CARMIL2 Mutations in Patients with Variable Clinical Dermatitis, Infections, and Combined Immunodeficiency by Alazami, Anas M, Al-Helale, Maryam, Alhissi, Safa, Al-Saud, Bandar, Alajlan, Huda, Monies, Dorota, Shah, Zeeshan, Abouelhoda, Mohamed, Arnaout, Rand, Al-Dhekri, Hasan, Al-Numair, Nouf S, Ghebeh, Hazem, Sheikh, Farrukh, Al-Mousa, Hamoud

“…Combined immunodeficiencies are a heterogeneous collection of primary immune disorders that exhibit defects in T cell development or function, along with…”
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A unique STK4 mutation truncating only the C-terminal SARAH domain results in a mild clinical phenotype despite severe T cell lymphopenia: Case report by Al-Saud, Bandar, Alajlan, Huda, Alruwaili, Hibah, Almoaibed, Latifa, Al-Mazrou, Amer, Ghebeh, Hazem, Al-Alwan, Monther, Alazami, Anas M

“…Mutations in STK4 (MST1) are implicated in a form of autosomal recessive combined immunodeficiency, resulting in recurrent infections (especially Epstein-Barr…”
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The B7-H1 (PD-L1) T Lymphocyte-Inhibitory Molecule Is Expressed in Breast Cancer Patients with Infiltrating Ductal Carcinoma: Correlation with Important High-Risk Prognostic Factors by Ghebeh, Hazem, Mohammed, Shamayel, Al-Omair, Abeer, Qattant, Amal, Lehe, Cynthia, Al-Qudaihi, Ghofran, Elkum, Naser, Alshabanah, Mohamed, Bin Amer, Suad, Tulbah, Asma, Ajarim, Dahish, Al-Tweigeri, Taher, Dermime, Said

“…B7-H1 molecule increases the apoptosis of tumorreactive T lymphocytes and reduces their immunogenicity. Breast cancer is the second most common cause of…”
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PD-L1 intrinsically promotes the proliferation of breast cancer cells through the SKP2-p27/p21 axis by Elfoly, Marwa, Mirza, Jumanah Y, Alaiya, Ayodele, Al-Hazzani, Amal A, Tulbah, Asma, Al-Alwan, Monther, Ghebeh, Hazem

“…PD-L1 intrinsically promotes tumor progression through multiple mechanisms, which potentially leads to resistance to anti-PD-1/PD-L1 therapies. The intrinsic…”
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Locally advanced nasopharyngeal carcinoma in adolescents treated with tomotherapy: Experience at King Faisal Specialist Hospital and Research Centre by Aldakheel, Abdulrahman, Aldehaim, Mohammed, Alwhaid, Mohammed Saleh, Alhabib, Renda, Anwar, Muhammad Suhail, Alzayed, Balqees, Shehzad, Khurram, Ghebeh, Hazem, Al-Rajhi, Nasser

“…Nasopharyngeal carcinoma (NPC) is a rare disease worldwide; To the best of our knowledge, there is no established standard of care specifically tailored for…”
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AUF1 promotes stemness in human mammary epithelial cells through stabilization of the EMT transcription factors TWIST1 and SNAIL1 by AlAhmari, Manar M., Al-Khalaf, Huda H., Al-Mohanna, Falah H., Ghebeh, Hazem, Aboussekhra, Abdelilah

“…The AU-rich element RNA-binding protein 1 (AUF1) is an RNA-binding protein, which can both stabilize and destabilize the transcripts of several cancer-related…”
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Comprehensive Transcriptome and Pathway Analyses Revealed Central Role for Fascin in Promoting Triple-Negative Breast Cancer Progression by Barnawi, Rayanah, Al-Khaldi, Samiyah, Majid, Salma, Qattan, Amal, Bakheet, Tala, Fallatah, Mohannad, Ghebeh, Hazem, Alajez, Nehad M, Al-Alwan, Monther

“…Recent years have witnessed major progress in development of novel therapeutic agents such as chemotherapy, targeted therapy and immune checkpoint inhibitors…”
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Metformin inhibits 7,12-dimethylbenz[a]anthracene-induced breast carcinogenesis and adduct formation in human breast cells by inhibiting the cytochrome P4501A1/aryl hydrocarbon receptor signaling pathway by Maayah, Zaid H., Ghebeh, Hazem, Alhaider, Abdulqader A., El-Kadi, Ayman O.S., Soshilov, Anatoly A., Denison, Michael S., Ansari, Mushtaq Ahmad, Korashy, Hesham M.

“…Recent studies have established that metformin (MET), an oral anti-diabetic drug, possesses antioxidant activity and is effective against different types of…”
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Neoadjuvant concurrent chemoradiotherapy using infusional gemcitabine in locally advanced rectal cancer: A phase II trial by Bazarbashi, Shouki, Elshenawy, Mahmoud A., Badran, Ahmed, Aljubran, Ali, Alzahrani, Ahmed, Almanea, Hadeel, Alsuhaibani, Abdullah, Alashwah, Ahmed, Neimatallah, Mohamed, Abduljabbar, Alaa, Ashari, Luai, Alhomoud, Samar, Ghebeh, Hazem, Elhassan, Tusneem, Alsanea, Nasser, Mohiuddin, Mohammed

“…Introduction Gemcitabine is a well‐known radiosensitizer. Herein, we tested the efficacy and toxicity of preoperative concurrent infusional gemcitabine and…”
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Higher PD-L1 Immunohistochemical Detection Signal in Frozen Compared to Matched Paraffin-Embedded Formalin-Fixed Tissues by Ghebeh, Hazem, Mansour, Fatmah A., Colak, Dilek, Alfuraydi, Akram A., Al-Thubiti, Amal A., Monies, Dorota, Al-Alwan, Monther, Al-Tweigeri, Taher, Tulbah, Asma

“…Purpose: Response to anti-PD-L1/PD-1 immunotherapy correlates with PD-L1 expression in breast cancer. However, the prevalence of PD-L1 positive breast cancer…”
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