Search Results - "Ghazoui, Z"

Potentially large post-1505 AD earthquakes in western Nepal revealed by a lake sediment record by Ghazoui, Z., Bertrand, S., Vanneste, K., Yokoyama, Y., Nomade, J., Gajurel, A. P., van der Beek, P. A.

“…According to paleoseismological studies, the last earthquake that ruptured the Main Frontal Thrust in western Nepal occurred in 1505 AD. No evidence of large…”
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Changes in breast cancer biomarkers in the IGF1R/PI3K pathway in recurrent breast cancer after tamoxifen treatment by Drury, S C, Detre, S, Leary, A, Salter, J, Reis-Filho, J, Barbashina, V, Marchio, C, Lopez-Knowles, E, Ghazoui, Z, Habben, K, Arbogast, S, Johnston, S, Dowsett, M

“…Development of resistance to the antioestrogen tamoxifen occurs in a large proportion of patients with oestrogen receptor-positive (ER+) breast cancer and is…”
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An in vitro model showing adaptation to long-term oestrogen deprivation highlights the clinical potential for targeting kinase pathways in combination with aromatase inhibition by Martin, L.-A., Ghazoui, Z., Weigel, M.T., Pancholi, Sunil, Dunbier, A., Johnston, Stephen, Dowsett, M.

“…Aromatase inhibitors (AI) have improved the treatment of oestrogen receptor positive (ER+) breast cancer. Despite the efficacy of these agents over 40% of…”
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Abstract PD01-05: Analysis of patients with ER-positive breast tumors treated with neoadjuvant aromatase inhibition identifies chemokine receptors as potential modulators of endocrine resistance by Ribas, R, Ghazoui, Z, Dowsett, M, Martin, L-A

“…Abstract Background: Most breast cancers (BC) at primary diagnosis are estrogen receptor positive (ER+). Estrogen (E) mediates its effects by binding to the…”
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Endocrine Therapy, New Biologicals, and New Study Designs for Presurgical Studies in Breast Cancer by Dowsett, Mitch, Smith, Ian, Robertson, John, Robison, Laura, Pinhel, Isabel, Johnson, Lindsay, Salter, Janine, Dunbier, Anita, Anderson, Helen, Ghazoui, Zara, Skene, Tony, Evans, Abigail, A'Hern, Roger, Iskender, Amanda, Wilcox, Maggie, Bliss, Judith

“…The preoperative setting is increasingly popular for the clinical investigation of hormonal agents and new biological drugs. The effectiveness of endocrine…”
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Late Quaternary evolution of Lago Castor (Chile, 45.6°S) : timing of the deglaciation in northern Patagonia and evolution of the westerlies during the last 17 kyr by van Daele, M., Bertrand, S., Meyer, I., Moernaut, J., Vandoome, W., Siani, G., Tanghe, N., Ghazoui, Z., Pino, M., Urrutia, R., de Batist, M.

“…Even though Patagonia is ideally located to study climate of the southern mid-latitudes, many questions on the late Quaternary climate evolution remain…”
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Comparison of the Transcriptional Response to Fulvestrant and Oestrogen Deprivation in ER-Positive Breast Cancer in Vitro and in Vivo by Patani, N., Dunbier, A., Anderson, H., Anderson, E., Gao, Q., Mackay, A., Ghazoui, Z., Kuter, I., Martin, L., Dowsett, M.

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Abstract S2-5: Molecular Profiling of Aromatase Inhibitor-Treated Post-Menopausal Breast Tumours Identifies Determinants of Response by Dunbier, AK, Ghazoui, Z, Anderson, H, Smith, IE, Dowsett, M.

“…Abstract Aim: To identify molecular mechanisms and predictors of response to aromatase inhibitors (AIs) in primary ER+ breast cancer. Background: Although AIs…”
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P4-01-01: Preclinical and Clinical Studies of Estrogen Deprivation Support the PDGF/Abl Pathway as a Novel Therapeutic Target for Overcoming Resistance by Weigel, MT, Banerjee, S, A'Hern, R, Arnedos, M, Ghazoui, Z, Dunbier, AK, Dowsett, M, Martin, L-A

“…Abstract Aim: To determine the relevance of PDGF/Abl signaling pathway as a therapeutic target in endocrine resistance in vitro and in vivo. Rationale:…”
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Abstract P1-12-02: Transcriptional Changes Induced by Anastrozole and Fulvestrant Treatment in ER-Positive Breast Cancers by Ghazoui, Z, Anderson, H, Dunbier, A, Anderson, E, Lindemann, J, Wellings, B, Walker, J, Kuter, I, Dowsett, M.

“…Abstract Aim: To compare changes in whole genome transcription elicited by anastrozole (ANA) and fulvestrant (FUL) in estrogen receptor positive (ER+) breast…”
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Aromatase Inhibitors Reduce the Expression of a Hypoxia Metagene in Oestrogen Receptor Positive Breast Cancer in Postmenopausal Women by Ghazoui, Z., Ghazoui, Z., Buffa, F., Dunbier, A., Dunbier, A., Anderson, H., Anderson, H., Dexter, T., Smith, I., Harris, A., Dowsett, M., Dowsett, M.

“…Abstract Aims: To (1) define the effect of oestrogen deprivation on genes related to hypoxia in oestrogen receptor positive (ER+) breast cancer and (2)…”
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Expression of estrogen responsive genes in breast cancers correlates with plasma estradiol levels in postmenopausal women by Dunbier, AK, Anderson, H, Folkerd, E, Ghazoui, Z, Smith, IE, Ellis, MJ, Dowsett, M, Group, Neoadjuvant Letrozole Study

“…Abstract Abstract #63 Background: Estrogen exposure is linked to the development and treatment of the majority of breast cancers. High estradiol (E2) levels…”
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