Search Results - "Ghazi, Terisha"

Fusaric acid decreases p53 expression by altering promoter methylation and m6A RNA methylation in human hepatocellular carcinoma (HepG2) cells by Ghazi, Terisha, Nagiah, Savania, Chuturgoon, Anil A.

“…Fusaric acid (FA) is a food-borne mycotoxin that mediates toxicity with limited information on its epigenetic properties. p53 is a tumour suppressor protein…”
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Malnutrition and Dietary Habits Alter the Immune System Which May Consequently Influence SARS-CoV-2 Virulence: A Review by Foolchand, Ashmika, Ghazi, Terisha, Chuturgoon, Anil A

“…COVID-19, resulting from the SARS-CoV-2 virus, is a major pandemic that the world is fighting. SARS-CoV-2 primarily causes lung infection by attaching to the…”
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A Critical Review of the Biochemical Mechanisms and Epigenetic Modifications in HIV- and Antiretroviral-Induced Metabolic Syndrome by Mohan, Jivanka, Ghazi, Terisha, Chuturgoon, Anil A

“…Metabolic syndrome (MetS) is a non-communicable disease characterised by a cluster of metabolic irregularities. Alarmingly, the prevalence of MetS in people…”
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The Potential of Spirulina platensis to Ameliorate the Adverse Effects of Highly Active Antiretroviral Therapy (HAART) by Sibiya, Thabani, Ghazi, Terisha, Chuturgoon, Anil

“…The human immunodeficiency virus (HIV) is one of the most prevalent diseases globally. It is estimated that 37.7 million people are infected with HIV globally,…”
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Fumonisin B1 alters global m6A RNA methylation and epigenetically regulates Keap1-Nrf2 signaling in human hepatoma (HepG2) cells by Arumugam, Thilona, Ghazi, Terisha, Chuturgoon, Anil A.

“…FB 1 is a common contaminant of cereal grains that affects human and animal health. It has become increasingly evident that epigenetic changes are implicated…”
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Fumonisin B1 Epigenetically Regulates PTEN Expression and Modulates DNA Damage Checkpoint Regulation in HepG2 Liver Cells by Arumugam, Thilona, Ghazi, Terisha, Chuturgoon, Anil

“…Fumonisin B1 (FB1), a Fusarium-produced mycotoxin, is found in various foods and feeds. It is a well-known liver carcinogen in experimental animals; however,…”
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Fusaric acid induces hepatic global m6A RNA methylation and differential expression of m6A regulatory genes in vivo - a pilot study by Ghazi, Terisha, Nagiah, Savania, Chuturgoon, Anil A.

“…N6-methyladenosine (m6A) is an abundant epitranscriptomic mark that regulates gene expression to execute cellular developmental programmes and environmental…”
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A Review: Highlighting the Links between Epigenetics, COVID-19 Infection, and Vitamin D by Foolchand, Ashmika, Mazaleni, Siyanda, Ghazi, Terisha, Chuturgoon, Anil A

“…The highly transmittable and infectious COVID-19 remains a major threat worldwide, with the elderly and comorbid individuals being the most vulnerable. While…”
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The Effect of Organoselenium Compounds on Histone Deacetylase Inhibition and Their Potential for Cancer Therapy by Adimulam, Theolan, Arumugam, Thilona, Foolchand, Ashmika, Ghazi, Terisha, Chuturgoon, Anil A

“…Genetic and epigenetic changes alter gene expression, contributing to cancer. Epigenetic changes in cancer arise from alterations in DNA and histone…”
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Fusaric Acid Induces DNA Damage and Post‐Translational Modifications of p53 in Human Hepatocellular Carcinoma (HepG2) Cells by Ghazi, Terisha, Nagiah, Savania, Tiloke, Charlette, Sheik Abdul, Naeem, Chuturgoon, Anil A.

“…ABSTRACT Fusaric acid (FA), a common fungal contaminant of maize, is known to mediate toxicity in plants and animals; however, its mechanism of action is…”
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Prenatal Air Pollution Exposure and Placental DNA Methylation Changes: Implications on Fetal Development and Future Disease Susceptibility by Ghazi, Terisha, Naidoo, Pragalathan, Naidoo, Rajen N, Chuturgoon, Anil A

“…The Developmental Origins of Health and Disease (DOHaD) concept postulates that in utero exposures influence fetal programming and health in later life…”
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Antiretrovirals Promote Insulin Resistance in HepG2 Liver Cells through miRNA Regulation and Transcriptional Activation of the NLRP3 Inflammasome by Mohan, Jivanka, Ghazi, Terisha, Mazibuko, Makabongwe S, Chuturgoon, Anil A

“…Metabolic syndrome (MetS) is a non-communicable disease characterized by a cluster of metabolic irregularities. Alarmingly, the prevalence of MetS in people…”
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SARS-CoV-2 and helminth co-infections, and environmental pollution exposure: An epidemiological and immunological perspective by Naidoo, Pragalathan, Ghazi, Terisha, Chuturgoon, Anil A., Naidoo, Rajen N., Ramsuran, Veron, Mpaka-Mbatha, Miranda N., Bhengu, Khethiwe N., Nembe, Nomzamo, Duma, Zamathombeni, Pillay, Roxanne, Singh, Ravesh, Mkhize-Kwitshana, Zilungile L.

“…•Cytokine storms are exacerbated in people co-exposed to COVID-19 and air pollution.•Helminths are potent activators of Th2 and Th3 anti-inflammatory immune…”
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Fusaric acid-induced promoter methylation of DNA methyltransferases triggers DNA hypomethylation in human hepatocellular carcinoma (HepG2) cells by Ghazi, Terisha, Nagiah, Savania, Naidoo, Pragalathan, Chuturgoon, Anil A.

“…Fusaric acid (FA), a mycotoxin contaminant of maize, displays toxicity in plants and animals; however, its epigenetic mechanism is unknown. DNA methylation, an…”
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Antiretrovirals Promote Metabolic Syndrome through Mitochondrial Stress and Dysfunction: An In Vitro Study by Mohan, Jivanka, Ghazi, Terisha, Sibiya, Thabani, Chuturgoon, Anil A

“…The prevalence of metabolic syndrome MetS in HIV-infected patients on chronic antiretroviral (ARV) therapy continues to rise rapidly, with an estimated 21%…”
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The Impact of Natural Dietary Compounds and Food-Borne Mycotoxins on DNA Methylation and Cancer by Ghazi, Terisha, Arumugam, Thilona, Foolchand, Ashmika, Chuturgoon, Anil A

“…Cancer initiation and progression is an accumulation of genetic and epigenetic modifications. DNA methylation is a common epigenetic modification that…”
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Spirulina platensis Ameliorates Oxidative Stress Associated with Antiretroviral Drugs in HepG2 Cells by Sibiya, Thabani, Ghazi, Terisha, Mohan, Jivanka, Nagiah, Savania, Chuturgoon, Anil A

“…Lately, Spirulina platensis (SP), as an antioxidant, has exhibited high potency in the treatment of oxidative stress, diabetes, immune disorder, inflammatory…”
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Fumonisin B2 Induces Mitochondrial Stress and Mitophagy in Human Embryonic Kidney (Hek293) Cells—A Preliminary Study by Mohan, Jivanka, Sheik Abdul, Naeem, Nagiah, Savania, Ghazi, Terisha, Chuturgoon, Anil A.

“…Ubiquitous soil fungi parasitise agricultural commodities and produce mycotoxins. Fumonisin B2 (FB2), the structural analogue of the commonly studied Fumonisin…”
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Moringa oleifera Lam Leaf Extract Stimulates NRF2 and Attenuates ARV-Induced Toxicity in Human Liver Cells (HepG2) by Ndlovu, Siqiniseko S, Chuturgoon, Anil A, Ghazi, Terisha

“…The World Health Organization (WHO) reported that there are 37 million individuals living with the human immunodeficiency virus (HIV) worldwide, with the…”
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Patulin activates the NRF2 pathway by modulation of miR-144 expression in HEK293 cells by Pillay, Yashodani, Ghazi, Terisha, Raghubeer, Shanel, Nagiah, Savania, Chuturgoon, Anil A.

“…Patulin (PAT) is a mycotoxin produced by various fungal species that commonly contaminate apples and other fruit products. PAT is associated with glutathione…”
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