Search Results - "Ghashghaei, H Troy"

Deep learning-based autofocus method enhances image quality in light-sheet fluorescence microscopy by Li, Chen, Moatti, Adele, Zhang, Xuying, Troy Ghashghaei, H, Greenabum, Alon

“…Light-sheet fluorescence microscopy (LSFM) is a minimally invasive and high throughput imaging technique ideal for capturing large volumes of tissue with…”
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Deep learning-based adaptive optics for light sheet fluorescence microscopy by Rai, Mani Ratnam, Li, Chen, Ghashghaei, H Troy, Greenbaum, Alon

“…Light sheet fluorescence microscopy (LSFM) is a high-speed imaging technique that is often used to image intact tissue-cleared specimens with cellular or…”
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Detection and classification of neurons and glial cells in the MADM mouse brain using RetinaNet by Cai, Yuheng, Zhang, Xuying, Kovalsky, Shahar Z, Ghashghaei, H Troy, Greenbaum, Alon

“…The ability to automatically detect and classify populations of cells in tissue sections is paramount in a wide variety of applications ranging from…”
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Neural Stem Cells to Cerebral Cortex: Emerging Mechanisms Regulating Progenitor Behavior and Productivity by Dwyer, Noelle D, Chen, Bin, Chou, Shen-Ju, Hippenmeyer, Simon, Nguyen, Laurent, Ghashghaei, H Troy

“…This review accompanies a 2016 SFN mini-symposium presenting examples of current studies that address a central question: How do neural stem cells (NSCs)…”
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Ependymal cell contribution to scar formation after spinal cord injury is minimal, local and dependent on direct ependymal injury by Ren, Yilong, Ao, Yan, O’Shea, Timothy M., Burda, Joshua E., Bernstein, Alexander M., Brumm, Andrew J., Muthusamy, Nagendran, Ghashghaei, H. Troy, Carmichael, S. Thomas, Cheng, Liming, Sofroniew, Michael V.

“…Ependyma have been proposed as adult neural stem cells that provide the majority of newly proliferated scar-forming astrocytes that protect tissue and function…”
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Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain by Muthusamy, Nagendran, Brumm, Andrew, Zhang, Xuying, Carmichael, S. Thomas, Ghashghaei, H. Troy

“…The stem cell source of neural and glial progenitors in the periventricular regions of the adult forebrain has remained uncertain and controversial. Using a…”
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FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain by Jacquet, Benoit V, Salinas-Mondragon, Raul, Liang, Huixuan, Therit, Blair, Buie, Justin D, Dykstra, Michael, Campbell, Kenneth, Ostrowski, Lawrence E, Brody, Steven L, Ghashghaei, H Troy

“…Neuronal specification occurs at the periventricular surface of the embryonic central nervous system. During early postnatal periods, radial glial cells in…”
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Unique glycan signatures regulate adeno-associated virus tropism in the developing brain by Murlidharan, Giridhar, Corriher, Travis, Ghashghaei, H Troy, Asokan, Aravind

“…Adeno-associated viruses (AAV) are thought to spread through the central nervous system (CNS) by exploiting cerebrospinal fluid (CSF) flux and hijacking axonal…”
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Neuronal migration in the adult brain: are we there yet? by Anton, E. S, Ghashghaei, H. Troy, Lai, Cary

“…The generation and targeting of appropriate numbers and types of neurons to where they are needed in the brain is essential for the establishment, maintenance…”
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Ependyma‐expressed CCN1 restricts the size of the neural stem cell pool in the adult ventricular‐subventricular zone by Wu, Jun, Tian, Wen‐Jia, Liu, Yang, Wang, Huanhuan J, Zheng, Jiangli, Wang, Xin, Pan, Han, Li, Ji, Luo, Junyu, Yang, Xuerui, Lau, Lester F, Ghashghaei, H Troy, Shen, Qin

“…Adult neural stem cells (NSCs) reside in specialized niches, which hold a balanced number of NSCs, their progeny, and other cells. How niche capacity is…”
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Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning by Muthusamy, Nagendran, Zhang, Xuying, Johnson, Caroline A, Yadav, Prem N, Ghashghaei, H Troy

“…In this study, the authors reveal distinct developmental programs underlying innate and learned olfactory behaviors by demonstrating that chemogenetic…”
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Stomach curvature is generated by left-right asymmetric gut morphogenesis by Davis, Adam, Amin, Nirav M, Johnson, Caroline, Bagley, Kristen, Ghashghaei, H Troy, Nascone-Yoder, Nanette

“…Left-right (LR) asymmetry is a fundamental feature of internal anatomy, yet the emergence of morphological asymmetry remains one of the least understood phases…”
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Regulation of cytokinesis during corticogenesis: focus on the midbody by Johnson, Caroline A., Wright, Catherine E., Ghashghaei, H. Troy

“…Development of the cerebral cortices depends on tight regulation of cell divisions. In this system, stem and progenitor cells undergo symmetric and asymmetric…”
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Influence of Desorption Conditions on Analyte Sensitivity and Internal Energy in Discrete Tissue or Whole Body Imaging by IR-MALDESI by Rosen, Elias P., Bokhart, Mark T., Ghashghaei, H. Troy, Muddiman, David C.

“…Analyte signal in a laser desorption/postionization scheme such as infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) is strongly…”
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Intelligent Beam Optimization for Light-Sheet Fluorescence Microscopy through Deep Learning by Li, Chen, Rai, Mani Ratnam, Cai, Yuheng, Ghashghaei, H Troy, Greenbaum, Alon

“…Light-sheet fluorescence microscopy (LSFM) provides the benefit of optical sectioning coupled with rapid acquisition times, enabling high-resolution…”
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A Nestin-cre transgenic mouse is insufficient for recombination in early embryonic neural progenitors by Liang, Huixuan, Hippenmeyer, Simon, Ghashghaei, H Troy

“…Nestin-cre transgenic mice have been widely used to direct recombination to neural stem cells (NSCs) and intermediate neural progenitor cells (NPCs). Here we…”
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TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus by Sai, Kazuhito, Morioka, Sho, Takaesu, Giichi, Muthusamy, Nagendran, Ghashghaei, H Troy, Hanafusa, Hiroshi, Matsumoto, Kunihiro, Ninomiya-Tsuji, Jun

“…Sustained endoplasmic reticulum (ER) stress disrupts normal cellular homeostasis and leads to the development of many types of human diseases, including…”
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Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain by Zhang, Xuying, Xiao, Guanxi, Johnson, Caroline, Cai, Yuheng, Horowitz, Zachary K., Mennicke, Christine, Coffey, Robert, Haider, Mansoor, Threadgill, David, Eliscu, Rebecca, Oldham, Michael C., Greenbaum, Alon, Ghashghaei, H. Troy

“…The epidermal growth factor receptor (EGFR) plays a role in cell proliferation and differentiation during healthy development and tumor growth; however, its…”
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Clonal Analysis of Gliogenesis in the Cerebral Cortex Reveals Stochastic Expansion of Glia and Cell Autonomous Responses to Egfr Dosage by Zhang, Xuying, Mennicke, Christine V, Xiao, Guanxi, Beattie, Robert, Haider, Mansoor A, Hippenmeyer, Simon, Ghashghaei, H Troy

“…Development of the nervous system undergoes important transitions, including one from neurogenesis to gliogenesis which occurs late during embryonic gestation…”
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Phosphorylation-dependent proteome of Marcks in ependyma during aging and behavioral homeostasis in the mouse forebrain by Muthusamy, Nagendran, Williams, Taufika I., O’Toole, Ryan, Brudvig, Jon J., Adler, Kenneth B., Weimer, Jill M., Muddiman, David C., Ghashghaei, H. Troy

“…Ependymal cells (ECs) line the ventricular surfaces of the mammalian central nervous system (CNS) and their development is indispensable to structural…”
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