Search Results - "Gharaibeh, Dima"

A potent Lassa virus antiviral targets an arenavirus virulence determinant by Madu, Ikenna G, Files, Megan, Gharaibeh, Dima N, Moore, Amy L, Jung, Kie-Hoon, Gowen, Brian B, Dai, Dongcheng, Jones, Kevin F, Tyavanagimatt, Shanthakumar R, Burgeson, James R, Korth, Marcus J, Bedard, Kristin M, Iadonato, Shawn P, Amberg, Sean M

“…Arenaviruses are a significant cause of hemorrhagic fever, an often-fatal disease for which there is no approved antiviral therapy. Lassa fever in particular…”
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Identification of a coumarin-based antihistamine-like small molecule as an anti-filoviral entry inhibitor by Cheng, Han, Schafer, Adam, Soloveva, Veronica, Gharaibeh, Dima, Kenny, Tara, Retterer, Cary, Zamani, Rouzbeh, Bavari, Sina, Peet, Norton P., Rong, Lijun

“…Filoviruses, consisting of Ebola virus, Marburg virus and Cuevavirus, cause severe hemorrhagic fevers in humans with high mortality rates up to 90%. Currently,…”
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Lead optimization of an acylhydrazone scaffold possessing antiviral activity against Lassa virus by Burgeson, James R., Gharaibeh, Dima N., Moore, Amy L., Larson, Ryan A., Amberg, Sean M., Bolken, Tove’ C., Hruby, Dennis E., Dai, Dongcheng

“…SAR analysis and optimization of an acylhydrazone-linked scaffold for potential treatment of arenavirus derived hemorrhagic fever. Previously we reported the…”
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Identification of agents effective against multiple toxins and viruses by host-oriented cell targeting by Zilbermintz, Leeor, Leonardi, William, Jeong, Sun-Young, Sjodt, Megan, McComb, Ryan, Ho, Chi-Lee C., Retterer, Cary, Gharaibeh, Dima, Zamani, Rouzbeh, Soloveva, Veronica, Bavari, Sina, Levitin, Anastasia, West, Joel, Bradley, Kenneth A., Clubb, Robert T., Cohen, Stanley N., Gupta, Vivek, Martchenko, Mikhail

“…A longstanding and still-increasing threat to the effective treatment of infectious diseases is resistance to antimicrobial countermeasures. Potentially, the…”
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SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity by Burgeson, James R., Moore, Amy L., Boutilier, Jordan K., Cerruti, Natasha R., Gharaibeh, Dima N., Lovejoy, Candace E., Amberg, Sean M., Hruby, Dennis E., Tyavanagimatt, Shanthakumar R., Allen, Robert D., Dai, Dongcheng

“…The SAR study of an acylthiourea scaffold capable of broad-spectrum antiviral activity is reported. A series of acylthiourea derivatives were designed,…”
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Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole by Dai, Dongcheng, Burgeson, James R., Gharaibeh, Dima N., Moore, Amy L., Larson, Ryan A., Cerruti, Natasha R., Amberg, Sean M., Bolken, Tove’ C., Hruby, Dennis E.

“…A chemically diverse library of about 400,000 small molecules was screened for antiviral activity against lentiviral pseudotypes with the Lassa virus envelope…”
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Development of monoclonal antibody-based assays for the detection of Vibrio tubiashii zinc-metalloprotease (VtpA) by Gharaibeh, Dima N., Biel, Frances M., Häse, Claudia C.

“…Vibrio tubiashii has been linked to disease outbreaks in molluscan species, including oysters, geoducks, and clams. In particular, oyster hatcheries in the…”
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Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole and related heterocycles by Burgeson, James R., Moore, Amy L., Gharaibeh, Dima N., Larson, Ryan A., Cerruti, Natasha R., Amberg, Sean M., Hruby, Dennis E., Dai, Dongcheng

“…Modifications to the core scaffold of broad-spectrum arenavirus inhibitors. A series of potent arenavirus inhibitors sharing a benzimidazole core were…”
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Anti-Ebola Activity of Diazachrysene Small Molecules by Selaković, Života, Soloveva, Veronica, Gharaibeh, Dima N, Wells, Jay, Šegan, Sandra, Panchal, Rekha G, Šolaja, Bogdan A

“…Herein we report on a diazachrysene class of small molecules that exhibit potent antiviral activity against the Ebola (EBOV) virus. The antiviral compounds are…”
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Development of a quantitative real-time PCR assay for detection of Vibrio tubiashii targeting the metalloprotease gene by Gharaibeh, Dima N., Hasegawa, Hiroaki, Häse, Claudia C.

“…Vibrio tubiashii has recently re-emerged as a pathogen of bivalve larvae, causing a marked increase in the mortality of these species within shellfish rearing…”
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Virulence of metalloproteases produced by Vibrio species on Pacific oyster Crassostrea gigas larvae by HASEGAWA, Hiroaki, GHARAIBEH, Dima N, LIND, Erin J, HÄSE, Claudia C

“…Vibrio tubiashii, a pathogen of shellfish larvae and juveniles, produces several extracellular products. Here, we document that culture supernatants of several…”
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Discovery of Novel Small-Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1 by Yi, Fei, Guo, Jia, Dabbagh, Deemah, Spear, Mark, He, Sijia, Kehn-Hall, Kylene, Fontenot, Jacque, Yin, Yan, Bibian, Mathieu, Park, Chul Min, Zheng, Ke, Park, Ha Jeung, Soloveva, Veronica, Gharaibeh, Dima, Retterer, Cary, Zamani, Rouzbeh, Pitt, Margaret L, Naughton, John, Jiang, Yongjun, Shang, Hong, Hakami, Ramin M, Ling, Binhua, Young, John A T, Bavari, Sina, Xu, Xuehua, Feng, Yangbo, Wu, Yuntao

“…A dynamic actin cytoskeleton is necessary for viral entry, intracellular migration, and virion release. For HIV-1 infection, during entry, the virus triggers…”
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Retrovirus-Based Surrogate Systems for BSL-2 High-Throughput Screening of Antivirals Targeting BSL-3/4 Hemorrhagic Fever-Causing Viruses by Radoshitzky, Sheli R, Soloveva, Veronica, Gharaibeh, Dima, Kuhn, Jens H, Bavari, Sina

“…The majority of viruses causing hemorrhagic fever in humans are Risk Group 3 or 4 pathogens and, therefore, can only be handled in biosafety level 3 or 4…”
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Bithionol blocks pathogenicity of bacterial toxins, ricin and Zika virus by Leonardi, William, Zilbermintz, Leeor, Cheng, Luisa W., Zozaya, Josue, Tran, Sharon H., Elliott, Jeffrey H., Polukhina, Kseniya, Manasherob, Robert, Li, Amy, Chi, Xiaoli, Gharaibeh, Dima, Kenny, Tara, Zamani, Rouzbeh, Soloveva, Veronica, Haddow, Andrew D., Nasar, Farooq, Bavari, Sina, Bassik, Michael C., Cohen, Stanley N., Levitin, Anastasia, Martchenko, Mikhail

“…Diverse pathogenic agents often utilize overlapping host networks and hub proteins within these networks represent attractive targets for broad-spectrum drugs…”
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Lateral-flow immunoassay for detecting drug-induced inhibition of mitochondrial DNA replication and mtDNA-encoded protein synthesis by Nadanaciva, Sashi, Willis, John H., Barker, Melissa L., Gharaibeh, Dima, Capaldi, Roderick A., Marusich, Michael F., Will, Yvonne

“…Drug-induced mitochondrial toxicity can occur as a result of inhibition of mitochondrial DNA (mtDNA) replication as with certain nucleoside reverse…”
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