Search Results - "Ghanta, Krishna S"

Melting dsDNA Donor Molecules Greatly Improves Precision Genome Editing in Caenorhabditis elegans by Ghanta, Krishna S, Mello, Craig C

“…Abstract Melting and fast cooling double stranded DNA donor molecules prior to injection dramatically increases the frequency of homology-directed repair for…”
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Stromal response to Hedgehog signaling restrains pancreatic cancer progression by Lee, John J, Perera, Rushika M, Wang, Huaijun, Wu, Dai-Chen, Liu, X Shawn, Han, Shiwei, Fitamant, Julien, Jones, Phillip D, Ghanta, Krishna S, Kawano, Sally, Nagle, Julia M, Deshpande, Vikram, Boucher, Yves, Kato, Tomoyo, Chen, James K, Willmann, Jürgen K, Bardeesy, Nabeel, Beachy, Philip A

“…Pancreatic ductal adenocarcinoma (PDA) is the most lethal of common human malignancies, with no truly effective therapies for advanced disease. Preclinical…”
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Bacterial processing of glucose modulates C. elegans lifespan and healthspan by Kingsley, Samuel F., Seo, Yonghak, Allen, Calista, Ghanta, Krishna S., Finkel, Steven, Tissenbaum, Heidi A.

“…Intestinal microbiota play an essential role in the health of a host organism. Here, we define how commensal Escherichia coli (E. coli) alters its host after…”
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Microinjection for precision genome editing in Caenorhabditis elegans by Ghanta, Krishna S., Ishidate, Takao, Mello, Craig C.

“…In Caenorhabditis elegans, targeted genome editing techniques are now routinely used to generate germline edits. The remarkable ease of C. elegans germline…”
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5'-Modifications improve potency and efficacy of DNA donors for precision genome editing by Ghanta, Krishna S, Chen, Zexiang, Mir, Aamir, Dokshin, Gregoriy A, Krishnamurthy, Pranathi M, Yoon, Yeonsoo, Gallant, Judith, Xu, Ping, Zhang, Xiao-Ou, Ozturk, Ahmet Rasit, Shin, Masahiro, Idrizi, Feston, Liu, Pengpeng, Gneid, Hassan, Edraki, Alireza, Lawson, Nathan D, Rivera-Pérez, Jaime A, Sontheimer, Erik J, Watts, Jonathan K, Mello, Craig C

“…Nuclease-directed genome editing is a powerful tool for investigating physiology and has great promise as a therapeutic approach to correct mutations that…”
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Robust Genome Editing with Short Single-Stranded and Long, Partially Single-Stranded DNA Donors in Caenorhabditis elegans by Dokshin, Gregoriy A, Ghanta, Krishna S, Piscopo, Katherine M, Mello, Craig C

“…CRISPR-based genome editing using ribonucleoprotein complexes and synthetic single-stranded oligodeoxynucleotide (ssODN) donors can be highly effective…”
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A co-CRISPR strategy for efficient genome editing in Caenorhabditis elegans by Kim, Heesun, Ishidate, Takao, Ghanta, Krishna S, Seth, Meetu, Conte, Jr, Darryl, Shirayama, Masaki, Mello, Craig C

“…Genome editing based on CRISPR (clustered regularly interspaced short palindromic repeats)-associated nuclease (Cas9) has been successfully applied in dozens…”
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Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer by Saha, Supriya K., Parachoniak, Christine A., Ghanta, Krishna S., Fitamant, Julien, Ross, Kenneth N., Najem, Mortada S., Gurumurthy, Sushma, Akbay, Esra A., Sia, Daniela, Cornella, Helena, Miltiadous, Oriana, Walesky, Chad, Deshpande, Vikram, Zhu, Andrew X., Hezel, Aram F., Yen, Katharine E., Straley, Kimberly S., Travins, Jeremy, Popovici-Muller, Janeta, Gliser, Camelia, Ferrone, Cristina R., Apte, Udayan, Llovet, Josep M., Wong, Kwok-Kin, Ramaswamy, Sridhar, Bardeesy, Nabeel

“…Gain-of-function mutations in isocitrate dehydrogenase ( IDH ) are among the most common genetic alterations in intrahepatic cholangiocarcinoma (IHCC), a…”
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A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors by Chen, Zexiang, Kwan, Suet-Yan, Mir, Aamir, Hazeltine, Max, Shin, Minwook, Liang, Shun-Qing, Chan, Io Long, Kelly, Karen, Ghanta, Krishna S, Gaston, Nicholas, Cao, Yueying, Xie, Jun, Gao, Guangping, Xue, Wen, Sontheimer, Erik J, Watts, Jonathan K

“…CRISPR-based genome-editing technologies, including nuclease editing, base editing, and prime editing, have recently revolutionized the development of…”
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Melting dsDNA Donor Molecules Greatly Improves Precision Genome Editing in Caenorhabditis elegans by Ghanta, Krishna S, Mello, Craig C

“…Melting and fast cooling double stranded DNA donor molecules prior to injection dramatically increases the frequency of homology-directed repair for edits such…”
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Correction: Corrigendum: Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer by Saha, Supriya K., Parachoniak, Christine A., Ghanta, Krishna S., Fitamant, Julien, Ross, Kenneth N., Najem, Mortada S., Gurumurthy, Sushma, Akbay, Esra A., Sia, Daniela, Cornella, Helena, Miltiadous, Oriana, Walesky, Chad, Deshpande, Vikram, Zhu, Andrew X., Hezel, Aram F., Yen, Katharine E., Straley, Kimberly S., Travins, Jeremy, Popovici-Muller, Janeta, Gliser, Camelia, Ferrone, Cristina R., Apte, Udayan, Llovet, Josep M., Wong, Kwok-Kin, Ramaswamy, Sridhar, Bardeesy, Nabeel

“…Nature 513, 110–114 (2014); doi:10.1038/nature13441 corrigendum Nature 519, 118 (2015); doi:10.1038/nature14149 In Extended Data Fig. 1b of this Letter, the…”
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Erratum: Corrigendum: Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer by Saha, Supriya K., Parachoniak, Christine A., Ghanta, Krishna S., Fitamant, Julien, Ross, Kenneth N., Najem, Mortada S., Gurumurthy, Sushma, Akbay, Esra A., Sia, Daniela, Cornella, Helena, Miltiadous, Oriana, Walesky, Chad, Deshpande, Vikram, Zhu, Andrew X., Hezel, Aram F., Yen, Katharine E., Straley, Kimberly S., Travins, Jeremy, Popovici-Muller, Janeta, Gliser, Camelia, Ferrone, Cristina R., Apte, Udayan, Llovet, Josep M., Wong, Kwok-Kin, Ramaswamy, Sridhar, Bardeesy, Nabeel

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Correction: Corrigendum: Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer by Saha, Supriya K., Parachoniak, Christine A., Ghanta, Krishna S., Fitamant, Julien, Ross, Kenneth N., Najem, Mortada S., Gurumurthy, Sushma, Akbay, Esra A., Sia, Daniela, Cornella, Helena, Miltiadous, Oriana, Walesky, Chad, Deshpande, Vikram, Zhu, Andrew X., Hezel, Aram F., Yen, Katharine E., Straley, Kimberly S., Travins, Jeremy, Popovici-Muller, Janeta, Gliser, Camelia, Ferrone, Cristina R., Apte, Udayan, Llovet, Josep M., Wong, Kwok-Kin, Ramaswamy, Sridhar, Bardeesy, Nabeel

“…Nature 513, 110–114 (2014); doi:10.1038/nature13441 In this Article, the last line of the Acknowledgements should read: J.M.L. and D.S. are supported by the…”
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Mutant IDH inhibits HNF-4[alpha] to block hepatocyte differentiation and promote biliary cancer by Saha, Supriya K, Parachoniak, Christine A, Ghanta, Krishna S, Fitamant, Julien, Ross, Kenneth N, Najem, Mortada S, Gurumurthy, Sushma, Akbay, Esra A, Sia, Daniela, Cornella, Helena, Miltiadous, Oriana, Walesky, Chad, Deshpande, Vikram, Zhu, Andrew X, Hezel, Aram F, Yen, Katharine E, Straley, Kimberly S, Travins, Jeremy, Popovici-Muller, Janeta, Gliser, Camelia, Ferrone, Cristina R, Apte, Udayan, Llovet, Josep M, Wong, Kwok-Kin, Ramaswamy, Sridhar, Bardeesy, Nabeel

“…Mutations inisocitrate dehydrogenase 1 (IDH1) and IDH2 are among the most common genetic alterations in intrahepatic cholangiocarcinoma (IHCC), a deadly liver…”
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Stromal response to Hedgehog signaling restrains pancreatic cancer progression by Lee, John J., Perera, Rushika M., Wang, Huaijun, Wu, Dai-Chen, Liu, X. Shawn, Han, Shiwei, Fitamant, Julien, Jones, Phillip D., Ghanta, Krishna S., Kawano, Sally, Nagle, Julia M., Deshpande, Vikram, Boucher, Yves, Kato, Tomoyo, Chen, James K., Willmann, Jürgen K., Bardeesy, Nabeel, Beachy, Philip A.

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Mutant IDH inhibits HNF4α to block hepatocyte differentiation and promote biliary cancer by Saha, Supriya K., Parachoniak, Christine A., Ghanta, Krishna S., Fitamant, Julien, Ross, Kenneth N., Najem, Mortada S., Gurumurthy, Sushma, Akbay, Esra A., Sia, Daniela, Cornella, Helena, Miltiadous, Oriana, Walesky, Chad, Deshpande, Vikram, Zhu, Andrew X., Hezel, Aram F., Yen, Katharine, Straley, Kim, Travins, Jeremy, Popovici-Muller, Janeta, Gliser, Camelia, Ferrone, Cristina R., Apte, Udayan, Llovet, Josep M., Wong, Kwok-Kin, Ramaswamy, Sridhar, Bardeesy, Nabeel

“…Mutations in Isocitrate dehydrogenase 1 ( IDH1 ) and IDH2 are among the most common genetic alterations in intrahepatic cholangiocarcinoma (IHCC), a deadly…”
Get full text

Corrigendum: Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer by Saha, Supriya K, Parachoniak, Christine A, Ghanta, Krishna S, Fitamant, Julien, Ross, Kenneth N, Najem, Mortada S, Gurumurthy, Sushma, Akbay, Esra A, Sia, Daniela, Cornella, Helena, Miltiadous, Oriana, Walesky, Chad, Deshpande, Vikram, Zhu, Andrew X, Hezel, Aram F, Yen, Katharine E, Straley, Kimberly S, Travins, Jeremy, Popovici-Muller, Janeta, Gliser, Camelia, Ferrone, Cristina R, Apte, Udayan, Llovet, Josep M, Wong, Kwok-Kin, Ramaswamy, Sridhar, Bardeesy, Nabeel

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