Search Results - "Ghanem, N."

CHIPing away at immunity: the role of clonal hematopoiesis of indeterminate potential in bacterial pneumonia by Bou Ghanem, Elsa N

“…The occurrence of clonal hematopoiesis of indeterminate potential (CHIP), in which advantageous somatic mutations result in the clonal expansion of blood…”
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Noninvasive electrocardiographic imaging for cardiac electrophysiology and arrhythmia by Rudy, Yoram, Ramanathan, Charulatha, Ghanem, Raja N, Jia, Ping, Ryu, Kyungmoo

“…Over 7 million people worldwide die annually from erratic heart rhythms (cardiac arrhythmias), and many more are disabled. Yet there is no imaging modality to…”
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Mitochondrial ROS production by neutrophils is required for host antimicrobial function against Streptococcus pneumoniae and is controlled by A2B adenosine receptor signaling by Herring, Sydney E, Mao, Sovathiro, Bhalla, Manmeet, Tchalla, Essi Y. I, Kramer, Jill M, Bou Ghanem, Elsa N

“…Polymorphonuclear cells (PMNs) control Streptococcus pneumoniae (pneumococcus) infection through various antimicrobial activities. We previously found that…”
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Extracellular Adenosine Protects against Streptococcus pneumoniae Lung Infection by Regulating Pulmonary Neutrophil Recruitment by Bou Ghanem, Elsa N, Clark, Stacie, Roggensack, Sara E, McIver, Sally R, Alcaide, Pilar, Haydon, Philip G, Leong, John M

“…An important determinant of disease following Streptococcus pneumoniae (pneumococcus) lung infection is pulmonary inflammation mediated by polymorphonuclear…”
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The prostaglandin D2 antagonist asapiprant ameliorates clinical severity in young hosts infected with invasive Streptococcus pneumoniae by Bhalla, Manmeet, Herring, Sydney, Lenhard, Alexsandra, Wheeler, Joshua R, Aswad, Fred, Klumpp, Klaus, Rebo, Justin, Wang, Yan, Wilhelmsen, Kevin, Fortney, Kristen, Bou Ghanem, Elsa N

“…(pneumococcus) remains a serious cause of pulmonary and systemic infections globally, and host-directed therapies are lacking. The aim of this study was to…”
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EP19.16: Sonographic assessment of a Caesarean scar following vaginal birth after Caesarean section: a prospective trial by Ashkar‐Majadla, N., Haj, H., Hasan, D., Sgayer, I., Ghanem, N., Lowenstein, L., Odeh, M.

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The α-tocopherol form of vitamin E reverses age-associated susceptibility to streptococcus pneumoniae lung infection by modulating pulmonary neutrophil recruitment by Bou Ghanem, Elsa N, Clark, Stacie, Du, Xiaogang, Wu, Dayong, Camilli, Andrew, Leong, John M, Meydani, Simin N

“…Streptococcus pneumoniae infections are an important cause of morbidity and mortality in older patients. Uncontrolled neutrophil-driven pulmonary inflammation…”
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Transcriptome Profiling Reveals CD73 and Age-Driven Changes in Neutrophil Responses against Streptococcus pneumoniae by Bhalla, Manmeet, Heinzinger, Lauren R, Morenikeji, Olanrewaju B, Marzullo, Brandon, Thomas, Bolaji N, Bou Ghanem, Elsa N

“…Neutrophils are required for host resistance against Streptococcus pneumoniae, but their function declines with age. We previously found that CD73, an enzyme…”
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Older but Not Wiser: the Age-Driven Changes in Neutrophil Responses during Pulmonary Infections by Simmons, Shaunna R, Bhalla, Manmeet, Herring, Sydney E, Tchalla, Essi Y I, Bou Ghanem, Elsa N

“…Elderly individuals are at increased risk of life-threatening pulmonary infections. Neutrophils are a key determinant of the disease course of pathogen-induced…”
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Venous thromboembolism and the utility of the Padua Prediction Score in patients with sepsis admitted to internal medicine departments by Vardi, M., Ghanem‐Zoubi, N. O., Zidan, R., Yurin, V., Bitterman, H.

“…Summary Background Sepsis is prevalent in internal medicine (IM) departments. Elderly patients with sepsis and chronic medical conditions are at an increased…”
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InlA promotes dissemination of Listeria monocytogenes to the mesenteric lymph nodes during food borne infection of mice by Bou Ghanem, Elsa N, Jones, Grant S, Myers-Morales, Tanya, Patil, Pooja D, Hidayatullah, Achmad N, D'Orazio, Sarah E F

“…Intestinal Listeria monocytogenes infection is not efficient in mice and this has been attributed to a low affinity interaction between the bacterial surface…”
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Extracellular adenosine enhances the ability of PMNs to kill Streptococcus pneumoniae by inhibiting IL‐10 production by Siwapornchai, Nalat, Lee, James N., Tchalla, Essi Y. I., Bhalla, Manmeet, Yeoh, Jun Hui, Roggensack, Sara E., Leong, John M., Bou Ghanem, Elsa N.

“…Polymorphonuclear leukocytes (PMNs) are crucial for initial control of Streptococcus pneumoniae (pneumococcus) lung infection; however, as the infection…”
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Extracellular adenosine signaling reverses the age‐driven decline in the ability of neutrophils to kill Streptococcus pneumoniae by Bhalla, Manmeet, Simmons, Shaunna R., Abamonte, Alexsandra, Herring, Sydney E., Roggensack, Sara E., Bou Ghanem, Elsa N.

“…Extracellular adenosine production by CD73 and signaling via A1 adenosine receptors is crucial for the ability of PMNs to kill engulfed Streptococcus…”
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Pneumolysin Induces 12-Lipoxygenase-Dependent Neutrophil Migration during Streptococcus pneumoniae Infection by Adams, Walter, Bhowmick, Rudra, Bou Ghanem, Elsa N, Wade, Kristin, Shchepetov, Mikhail, Weiser, Jeffrey N, McCormick, Beth A, Tweten, Rodney K, Leong, John M

“…is a major cause of pneumonia, wherein infection of respiratory mucosa drives a robust influx of neutrophils. We have previously shown that infection of the…”
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Activating A1 adenosine receptor signaling boosts early pulmonary neutrophil recruitment in aged mice in response to Streptococcus pneumoniae infection by Simmons, Shaunna R, Herring, Sydney E, Tchalla, Essi Y I, Lenhard, Alexsandra P, Bhalla, Manmeet, Bou Ghanem, Elsa N

“…Streptococcus pneumoniae (pneumococcus) is a leading cause of pneumonia in older adults. Successful control of pneumococci requires robust pulmonary neutrophil…”
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Editorial: Transmission, colonization, and molecular pathogenesis of pneumococcus by Vidal, Jorge E., Bou Ghanem, Elsa N., Wu, Xueqing, Wu, Kaifeng, Bai, Guangchun, Hammerschmidt, Sven

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The Age-Driven Decline in Neutrophil Function Contributes to the Reduced Efficacy of the Pneumococcal Conjugate Vaccine in Old Hosts by Simmons, Shaunna R, Tchalla, Essi Y I, Bhalla, Manmeet, Bou Ghanem, Elsa N

“…Despite the availability of vaccines, (pneumococcus) remains a serious cause of infections in the elderly. The efficacy of anti-pneumococcal vaccines declines…”
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Nasopharyngeal Exposure to Streptococcus pneumoniae Induces Extended Age-Dependent Protection against Pulmonary Infection Mediated by Antibodies and CD138 + Cells by Bou Ghanem, Elsa N, Maung, Nang H Tin, Siwapornchai, Nalat, Goodwin, Aaron E, Clark, Stacie, Muñoz-Elías, Ernesto J, Camilli, Andrew, Gerstein, Rachel M, Leong, John M

“…commonly resides asymptomatically in the nasopharyngeal (NP) cavity of healthy individuals but can cause life-threatening pulmonary and systemic infections,…”
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Combination of drug and stem cells neurotherapy: Potential interventions in neurotrauma and traumatic brain injury by Zibara, Kazem, Ballout, Nissrine, Mondello, Stefania, Karnib, Nabil, Ramadan, Naify, Omais, Saad, Nabbouh, Ali, Caliz, Daniela, Clavijo, Angelica, Hu, Zhen, Ghanem, Noël, Gajavelli, Shyam, Kobeissy, Firas

“…Traumatic brain injury (TBI) has been recognized as one of the major public health issues that leads to devastating neurological disability. As a consequence…”
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A1 adenosine receptor signaling reduces Streptococcus pneumoniae adherence to pulmonary epithelial cells by targeting expression of platelet‐activating factor receptor by Bhalla, Manmeet, Hui Yeoh, Jun, Lamneck, Claire, Herring, Sydney E., Tchalla, Essi Y.I., Heinzinger, Lauren R., Leong, John M., Bou Ghanem, Elsa N.

“…Extracellular adenosine production is crucial for host resistance against Streptococcus pneumoniae (pneumococcus) and is thought to affect antibacterial immune…”
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