Search Results - "Ghanefar, Mohsen"

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation by Ichikawa, Yoshihiko, Ghanefar, Mohsen, Bayeva, Marina, Wu, Rongxue, Khechaduri, Arineh, Naga Prasad, Sathyamangla V, Mutharasan, R Kannan, Naik, Tejaswitha Jairaj, Ardehali, Hossein

“…Doxorubicin is an effective anticancer drug with known cardiotoxic side effects. It has been hypothesized that doxorubicin-dependent cardiotoxicity occurs…”
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Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export by Ichikawa, Yoshihiko, Bayeva, Marina, Ghanefar, Mohsen, Potini, Vishnu, Sun, Lin, Mutharasan, R. Kannan, Wu, Rongxue, Khechaduri, Arineh, Jairaj Naik, Tejaswitha, Ardehali, Hossein

“…Mitochondrial iron levels are tightly regulated, as iron is essential for the synthesis of Fe/S clusters and heme in the mitochondria, but high levels can…”
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Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production by Wu, Rongxue, Wyatt, Eugene, Chawla, Kusum, Tran, Minh, Ghanefar, Mohsen, Laakso, Markku, Epting, Conrad L., Ardehali, Hossein

“…Hexokinase‐II (HKII) is highly expressed in the heart and can bind to the mitochondrial outer membrane. Since cardiac hypertrophy is associated with a…”
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Regulation and cytoprotective role of hexokinase III by Wyatt, Eugene, Wu, Rongxue, Rabeh, Wael, Park, Hee-Won, Ghanefar, Mohsen, Ardehali, Hossein

“…Hexokinases (HKs) catalyze the first step in glucose metabolism. Of the three mammalian 100-kDa HK isoforms, HKI and II can bind to mitochondria and protect…”
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Cardiac-specific ablation of ARNT leads to lipotoxicity and cardiomyopathy by Wu, Rongxue, Chang, Hsiang-Chun, Khechaduri, Arineh, Chawla, Kusum, Tran, Minh, Chai, Xiaomeng, Wagg, Cory, Ghanefar, Mohsen, Jiang, Xinghang, Bayeva, Marina, Gonzalez, Frank, Lopaschuk, Gary, Ardehali, Hossein

“…Patients with type 2 diabetes often present with cardiovascular complications; however, it is not clear how diabetes promotes cardiac dysfunction. In murine…”
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Early long‐term L‐T3 replacement rescues mitochondria and prevents ischemic cardiac remodelling in rats by Forini, Francesca, Lionetti, Vincenzo, Ardehali, Hossein, Pucci, Angela, Cecchetti, Federica, Ghanefar, Mohsen, Nicolini, Giuseppina, Ichikawa, Yoshihiko, Nannipieri, Monica, Recchia, Fabio A., Iervasi, Giorgio

“…3,5,3′‐Levo‐triiodothyronine (L‐T3) is essential for DNA transcription, mitochondrial biogenesis and respiration, but its circulating levels rapidly decrease…”
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Abstract 16841: Cardiac Deletion of Aryl Hydrocarbon Nuclear Translocator (Hypoxia Inducible Factor 1-beta) in the Adult Heart Leads to Cardiomyopathy Due to Lipid Accumulation via Peroxisome Proliferator Activated Receptor Activation by Wu, Rongxue, Chawla, Kusum, Ghanefar, Mohsen, Ardehali, Hossein

“…Abstract only Background: Aryl hydrocarbon receptor nuclear translocator (ARNT), also known as hypoxia-inducible factor 1-beta (HIF1-beta), serves as a binding…”
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Abstract 15414: Ablation of Aryl Hydrocarbon Nuclear Translocator (ARNT) in the Heart Leads to Diabetic Cardiomyopathy Phenotype Through PPARα Activity by Wu, Rongxue, Chang, Hsiang Chun, Tran, Minh, Chawla, Kusum, Khechaduri, Arineh, Chai, Xiaomeng, Ghanefar, Mohsen, Bayeva, Marina, Wagg, Cory, Gonzalez, Frank, Lopaschuk, Gary, Ardehali, Hossein

“…Abstract only Background: Metabolic changes decrease cardiac efficiency and energetics in diabetes. Impaired hypoxia inducible factor (HIF) signaling may…”
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Cardiac-specific ablation of ARNT leads to lipotoxicity and cardiomyopathy by Wu, Rongxue, Chang, Hsiang-Chun, Khechaduri, Arineh, Chawla, Kusum, Tran, Minh, Chai, Xiaomeng, Wagg, Cory, Ghanefar, Mohsen, Jiang, Xinghang, Bayeva, Marina, Gonzalez, Frank, Lopaschuk, Gary, Ardehali, Hossein

“…Patients with type 2 diabetes often present with cardiovascular complications; however, it is not clear how diabetes promotes cardiac dysfunction. In murine…”
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Abstract P214: Reduction of Hexokinase II Exaggerated Cardiac Hypertrophy via Increased ROS Production and Mitochondrial Permeability Transition by Wyatt, Eugene J, Wu, Rongxue, Chawla, Kusum, Ghanefar, Mohsen, Ardehali, Hossein

“…Abstract only Rationale/Objective: Cardiac hypertrophy is associated with a metabolic switch in substrate utilization from fatty acids to glucose. Levels of…”
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