Comparison of Treatment Response Achieved by Tablet Splitting Versus Whole Tablet Administration of Levothyroxine in Patients with Thyroid Cancer

Comparison of Treatment Response Achieved by Tablet Splitting Versus Whole Tablet Administration of Levothyroxine in Patients with Thyroid Cancer

Objective(s):TSH suppression by Levothyroxine consumption is a mainstay of thyroid cancer treatment. Tablet-splitting is a worldwide approach in dose adjustment in patients. However, it is highly recommended to evaluate the validity of tablet splitting for each distinctive drug by clinical trials be...

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Bibliographic Details
Published in:Asia oceania journal of nuclear medicine and biology Vol. 6; no. 2; pp. 108 - 112
Main Authors: Ashrafpour Ramin, ayati Narjess, Sadeghi Ramin, Zare, Namdar Samira, Nayyereh, Ayati, Ghahremani Somayyeh, Zakavi, Seyed Rasoul
Format: Journal Article
Language:English
Published: Mashhad Mashhad University of Medical Sciences 01-01-2018
Subjects:
Age composition
Clinical trials
Differentiated thyroid cancer, TSH, Levothyroxine, suppressive therapy
Drug dosages
Iodine
Original
Patients
Preferences
Serum levels
Splitting
Tablet splitting
Tablets
Thyroid cancer
Thyroid-stimulating hormone
Thyroxine
Triiodothyronine
Iran
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Summary:Objective(s):TSH suppression by Levothyroxine consumption is a mainstay of thyroid cancer treatment. Tablet-splitting is a worldwide approach in dose adjustment in patients. However, it is highly recommended to evaluate the validity of tablet splitting for each distinctive drug by clinical trials before routinely using tablet halves in clinical practice. In this study we compared the effect of 150 µg dose of Levothyroxine by use of a100 and a 50 µg tablets or one and half 100 µg tablets in Differentiated thyroid cancer (DTC) patients.Methods:One hundred DTC patients treated with one and half 100 µg Levothyroxine tablets were randomly divided into two groups. The first group continued taking medication as before and the second group received the same daily dose by taking one 100 and one 50 microgram Levothyroxine tablets. The mean changes in TSH and T3 levels and patients weight were compared between the groups.Results:91 patients completed the study. Levothyroxine consumption pattern, age, gender distribution, weight and TSH levels were comparable between groups at the beginning of the study. The mean change of body weights, serum levels of T3 and TSH showed no significant difference between groups in different time points during the study (P>0.05). Conclusion:This study showed similar efficacy of tablet splitting and two tablets administration for Levothyroxine; however, patients preferred two tablets at the end of the study. It can be concluded that tablet splitting can be used as an alternative way when the 50 µg tablet is not available.
ISSN:2322-5718
2322-5726
DOI:10.22038/aojnmb.2018.26793.1187