Search Results - "Ghafoory, Shahrouz"

In Vitro Generation of Functional Liver Organoid-Like Structures Using Adult Human Cells by Ramachandran, Sarada Devi, Schirmer, Katharina, Münst, Bernhard, Heinz, Stefan, Ghafoory, Shahrouz, Wölfl, Stefan, Simon-Keller, Katja, Marx, Alexander, Øie, Cristina Ionica, Ebert, Matthias P, Walles, Heike, Braspenning, Joris, Breitkopf-Heinlein, Katja

“…In this study we used differentiated adult human upcyte® cells for the in vitro generation of liver organoids. Upcyte® cells are genetically engineered cell…”
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Zonation of nitrogen and glucose metabolism gene expression upon acute liver damage in mouse by Ghafoory, Shahrouz, Breitkopf-Heinlein, Katja, Li, Qi, Scholl, Catharina, Dooley, Steven, Wölfl, Stefan

“…Zonation of metabolic activities within specific structures and cell types is a phenomenon of liver organization and ensures complementarity of variant liver…”
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Platelet TGF-β1 deficiency decreases liver fibrosis in a mouse model of liver injury by Ghafoory, Shahrouz, Varshney, Rohan, Robison, Tyler, Kouzbari, Karim, Woolington, Sean, Murphy, Brennah, Xia, Lijun, Ahamed, Jasimuddin

“…Transforming growth factor-β1 (TGF-β1) signaling in hepatic stellate cells (HSCs) plays a primary role in liver fibrosis, but the source of TGF-β1 is unclear…”
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HIV protease inhibitor-induced cardiac dysfunction and fibrosis is mediated by platelet-derived TGF-β1 and can be suppressed by exogenous carbon monoxide by Laurence, Jeffrey, Elhadad, Sonia, Robison, Tyler, Terry, Hunter, Varshney, Rohan, Woolington, Sean, Ghafoory, Shahrouz, Choi, Mary E, Ahamed, Jasimuddin

“…Human immunodeficiency virus (HIV) infection is an independent risk factor for cardiovascular disease. This risk is magnified by certain antiretrovirals,…”
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Bone morphogenetic protein‐9 induces epithelial to mesenchymal transition in hepatocellular carcinoma cells by Li, Qi, Gu, Xing, Weng, Honglei, Ghafoory, Shahrouz, Liu, Yan, Feng, Teng, Dzieran, Johanna, Li, Li, Ilkavets, Iryna, Kruithof‐ de Julio, Marianna, Munker, Stefan, Marx, Alexander, Piiper, Albrecht, Augusto Alonso, Eduardo, Gretz, Norbert, Gao, Chunfang, Wölfl, Stefan, Dooley, Steven, Breitkopf‐Heinlein, Katja

“…Epithelial‐mesenchymal transition (EMT) is an important mechanism to initiate cancer invasion and metastasis. Bone morphogenetic protein (BMP)‐9 is a member of…”
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Development of an Artificial 3D Liver Phantom for Analysis of Radiotherapeutic Effects In Vitro by Stengl, Christina, Ghafoory, Shahrouz, Weidner, Artur, Murphy, Brennah, Wölfl, Stefan

“…Over recent decades, stereotactic body radiotherapy has garnered increasing popularity. Unfortunately, conventional preclinical 2D in vitro models are often…”
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Oxygen Gradient Induced in Microfluidic Chips Can Be Used as a Model for Liver Zonation by Ghafoory, Shahrouz, Stengl, Christina, Kopany, Stefan, Mayadag, Mert, Mechtel, Nils, Murphy, Brennah, Schattschneider, Sebastian, Wilhelmi, Niklas, Wölfl, Stefan

“…Availability of oxygen plays an important role in tissue organization and cell-type specific metabolism. It is, however, difficult to analyze hypoxia-related…”
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Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs by Cheng, Xinlai, Kim, Jee Young, Ghafoory, Shahrouz, Duvaci, Tijen, Rafiee, Roya, Theobald, Jannick, Alborzinia, Hamed, Holenya, Pavlo, Fredebohm, Johannes, Merz, Karl-Heinz, Mehrabi, Arianeb, Hafezi, Mohammadreza, Saffari, Arash, Eisenbrand, Gerhard, Hoheisel, Jörg D., Wölfl, Stefan

“…Pancreatic ductal adenocarcinoma (PDAC) clinically has a very poor prognosis. No small molecule is available to reliably achieve cures. Meisoindigo is…”
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Inactivation of platelet-derived TGF-β1 attenuates aortic stenosis progression in a robust murine model by Varshney, Rohan, Murphy, Brennah, Woolington, Sean, Ghafoory, Shahrouz, Chen, Sixia, Robison, Tyler, Ahamed, Jasimuddin

“…Aortic stenosis (AS) is a degenerative heart condition characterized by fibrosis and narrowing of aortic valves (AV), resulting in high wall shear stress (WSS)…”
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NHC-gold compounds mediate immune suppression through induction of AHR-TGFβ1 signalling in vitro and in scurfy mice by Cheng, Xinlai, Haeberle, Stefanie, Shytaj, Iart Luca, Gama-Brambila, Rodrigo. A., Theobald, Jannick, Ghafoory, Shahrouz, Wölker, Jessica, Basu, Uttara, Schmidt, Claudia, Timm, Annika, Taškova, Katerina, Bauer, Andrea S., Hoheisel, Jörg, Tsopoulidis, Nikolaos, Fackler, Oliver T., Savarino, Andrea, Andrade-Navarro, Miguel A., Ott, Ingo, Lusic, Marina, Hadaschik, Eva N., Wölfl, Stefan

“…Gold compounds have a long history of use as immunosuppressants, but their precise mechanism of action is not completely understood. Using our recently…”
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Mice with Platelet/Megakaryocyte-Specific Deletion of TGF-β1 Are Partially Protected from Liver Fibrosis in a CCl4-Induced Liver Injury Model by Ghafoory, Shahrouz, Varshney, Rohan, Ahamed, Jasimuddin

“…Platelets contain a high concentration of transforming growth factor β1 (TGFβ1). Platelet TGFβ1 has been shown to contribute to plasma TGFβ1 levels and…”
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TGF-β2 silencing to target biliary-derived liver diseases by Dropmann, Anne, Dooley, Steven, Dewidar, Bedair, Hammad, Seddik, Dediulia, Tatjana, Werle, Julia, Hartwig, Vanessa, Ghafoory, Shahrouz, Woelfl, Stefan, Korhonen, Hanna, Janicot, Michel, Wosikowski, Katja, Itzel, Timo, Teufel, Andreas, Schuppan, Detlef, Stojanovic, Ana, Cerwenka, Adelheid, Nittka, Stefanie, Piiper, Albrecht, Gaiser, Timo, Beraza, Naiara, Milkiewicz, Malgorzata, Milkiewicz, Piotr, Brain, John G, Jones, David E J, Weiss, Thomas S, Zanger, Ulrich M, Ebert, Matthias, Meindl-Beinker, Nadja M

“…TGF-β2 (TGF-β, transforming growth factor beta), the less-investigated sibling of TGF-β1, is deregulated in rodent and human liver diseases. Former data from…”
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pVHL-mediated SMAD3 degradation suppresses TGF-β signaling by Zhou, Jun, Dabiri, Yasamin, Gama-Brambila, Rodrigo A, Ghafoory, Shahrouz, Altinbay, Mukaddes, Mehrabi, Arianeb, Golriz, Mohammad, Blagojevic, Biljana, Reuter, Stefanie, Han, Kang, Seidel, Anna, Đikić, Ivan, Wölfl, Stefan, Cheng, Xinlai

“…Transforming growth factor β (TGF-β) signaling plays a fundamental role in metazoan development and tissue homeostasis. However, the molecular mechanisms…”
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Mice Lacking Platelet TGF-β1 Are Protected from Aortic Stenosis Progression by Varshney, Rohan, Murphy, Brennah, Ghafoory, Shahrouz, Robison, Tyler, Woolington, Sean, Ahamed, Jasimuddin

“…Introduction and Hypothesis: Aortic stenosis (AS) is an age-related disease primarily affecting the elderly and is characterized by accelerated fibrosis in the…”
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HIV protease inhibitor-induced cardiac dysfunction and fibrosis is mediated by platelet-derived TGF-[beta]1 and can be suppressed by exogenous carbon monoxide by Laurence, Jeffrey, Elhadad, Sonia, Robison, Tyler, Terry, Hunter, Varshney, Rohan, Woolington, Sean, Ghafoory, Shahrouz, Choi, Mary E, Ahamed, Jasimuddin

“…Human immunodeficiency virus (HIV) infection is an independent risk factor for cardiovascular disease. This risk is magnified by certain antiretrovirals,…”
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A fast and efficient polymerase chain reaction-based method for the preparation of in situ hybridization probes by Ghafoory, Shahrouz, Breitkopf-Heinlein, Katja, Li, Qi, Dzieran, Johanna, Scholl, Catharina, Dooley, Steven, Wölfl, Stefan

“…Ghafoory S, Breitkopf‐Heinlein K, Li Q, Dzieran J, Scholl C, Dooley S & Wölfl S 
(2012) Histopathology 61, 306–313 A fast and efficient polymerase chain…”
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NHC-gold compounds mediate immune suppression through induction of AHR-TGFβ1 signalling in vitro and in scurfy mice by Cheng, Xinlai, Haeberle, Stefanie, Luca Shytaj, Iart, Gama-Brambila, Rodrigo A, Theobald, Jannick, Ghafoory, Shahrouz, Wölker, Jessica, Basu, Uttara, Schmidt, Claudia, Timm, Annika, Taškova, Katerina, Bauer, Andrea S, Hoheisel, Jörg, Tsopoulidis, Nikolaos, Fackler, Oliver T, Savarino, Andrea, Andrade-Navarro, Miguel A, Ott, Ingo, Lusic, Marina, Hadaschik, Eva N, Wölfl, Stefan

“…Gold compounds have a long history of use as immunosuppressants, but their precise mechanism of action is not completely understood. Using our recently…”
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BMP‐9 induces EMT in hepatocellular carcinoma cells. Immunofluorescent staining against BMP‐9 (green) and E‐cadherin (red) of a hepatocellular carcinoma section from TNFα/cmyc bitransgenic mouse by Li, Qi, Gu, Xing, Weng, Honglei, Ghafoory, Shahrouz, Liu, Yan, Feng, Teng, Dzieran, Johanna, Li, Li, Ilkavets, Iryna, Julio, Marianna Kruithof‐, Munker, Stefan, Marx, Alexander, Piiper, Albrecht, Augusto Alonso, Eduardo, Gretz, Norbert, Gao, Chunfang, Wölfl, Stefan, Dooley, Steven, Breitkopf‐Heinlein, Katja

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Zonation of Nitrogen and Glucose Metabolism Gene Expression upon Acute Liver Damage in Mouse: e78262 by Ghafoory, Shahrouz, Breitkopf-Heinlein, Katja, Li, Qi, Scholl, Catharina, Dooley, Steven, Wolfl, Stefan

“…Zonation of metabolic activities within specific structures and cell types is a phenomenon of liver organization and ensures complementarity of variant liver…”
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