Search Results - "Ghaffari, Seyed H."

The role of toll‐like receptor 4 (TLR4) in cancer progression: A possible therapeutic target? by Kashani, Bahareh, Zandi, Zahra, Pourbagheri‐Sigaroodi, Atieh, Bashash, Davood, Ghaffari, Seyed H.

“…The toll‐like receptor (TLR) family consists of vital receptors responsible for pattern recognition in innate immunity, making them the core proteins involved…”
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Resistance to immunotherapy in human malignancies: Mechanisms, research progresses, challenges, and opportunities by Bashash, Davood, Zandi, Zahra, Kashani, Bahareh, Pourbagheri‐Sigaroodi, Atieh, Salari, Sina, Ghaffari, Seyed H.

“…Despite remarkable advances in different types of cancer therapies, an effective therapeutic strategy is still a major and significant challenge. One of the…”
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The DNA Methylation in Neurological Diseases by Younesian, Samareh, Yousefi, Amir-Mohammad, Momeny, Majid, Ghaffari, Seyed H, Bashash, Davood

“…DNA methylation is critical for the normal development and functioning of the human brain, such as the proliferation and differentiation of neural stem cells,…”
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Lung cancer-associated brain metastasis: Molecular mechanisms and therapeutic options by Yousefi, Meysam, Bahrami, Tayyeb, Salmaninejad, Arash, Nosrati, Rahim, Ghaffari, Parisa, Ghaffari, Seyed H.

“…Background Lung cancer is the most common cause of cancer-related mortality in humans. There are several reasons for this high rate of mortality, including…”
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EGFR Blockade Reverses Cisplatin Resistance in Human Epithelial Ovarian Cancer Cells by Poursheikhani, Arash, Yousefi, Hassan, Tavakoli-bazzaz, Javad, Ghaffari, Seyed H.

“…Background: Epithelial ovarian cancer (EOC) is one of the most lethal gynecological malignancy worldwide. Although the majority of EOC patients achieve…”
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Overexpression of Bromodomain and Extraterminal Domain is Associated with Progression, Metastasis and Unfavorable Outcomes: Highlighting Prognostic and Therapeutic Value of the BET Protein Family in Gastric Cancer by Fard, Shahrzad S, Kouchaki, Shaghayegh, Salimian, Zahra, Sotoudeh, Masoud, Mousavi, Seyed A, Alimoghaddam, Kamran, Ghaffari, Seyed H

“…As epigenetic readers, Bromodomain and extraterminal domain (BET) proteins have attracted immense interest in developing novel therapies targeting this family…”
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The effects of Abemaciclib on cell cycle and apoptosis regulation in anaplastic thyroid cancer cells by Abutorabi, Elaheh S., Poursheikhani, Arash, Kashani, Bahareh, Shamsaiegahkani, Sahar, Haghpanah, Vahid, Bashash, Davood, Mousavi, Seied A., Momeny, Majid, Ghaffari, Seyed H.

“…Background: Anaplastic thyroid cancer (ATC) is an aggressive subtype of thyroid cancer, accounting for 1 to 2% of all cases. Deregulations of cell cycle…”
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Metabolism of Arsenic Trioxide in Acute Promyelocytic Leukemia Cells by Khaleghian, Ali, Ghaffari, Seyed H., Ahmadian, Shahin, Alimoghaddam, Kamran, Ghavamzadeh, Ardeshir

“…Arsenic trioxide (As2O3) effectively induces complete clinical and molecular remissions in acute promyelocytic leukemia (APL) patients and triggers apoptosis…”
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Alteration of PPAR‐GAMMA (PPARG; PPARγ) and PTEN gene expression in acute myeloid leukemia patients and the promising anticancer effects of PPARγ stimulation using pioglitazone on AML cells by Esmaeili, Shadi, Salari, Sina, Kaveh, Vahid, Ghaffari, Seyed H., Bashash, Davood

“…Background In the new era of tailored cancer treatment strategies, finding a molecule to regulate a wide range of intracellular functions is valuable. The…”
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Residual methylation of tumor suppressor gene promoters, RASSF6 and RASSF10, as novel biomarkers for minimal residual disease detection in adult acute lymphoblastic leukemia by Younesian, Samareh, Shahkarami, Sepideh, Ghaffari, Parisa, Alizadeh, Shaban, Mehrasa, Roya, Ghaffari, Seyed H.

“…Aberrant promoter methylation of RASSF6 and RASSF10 occurs at a high frequency in acute lymphoblastic leukemia (ALL). Because of the complexity of the current…”
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IL-6/IL-6R pathway is a therapeutic target in chemoresistant ovarian cancer by Yousefi, Hassan, Momeny, Majid, Ghaffari, Seyed H., Parsanejad, Nazanin, Poursheikhani, Arash, Javadikooshesh, Sepehr, Zarrinrad, Ghazaleh, Esmaeili, Fatemeh, Alishahi, Zivar, Sabourinejad, Zahra, Sankanian, Ghazaleh, Shamsaiegahkani, Sahar, Bashash, Davood, Shahsavani, Narjes, Tavakkoly-Bazzaz, Javad, Alimoghaddam, Kamran, Ghavamzadeh, Ardeshir

“…Introduction: Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy worldwide and despite an initial response to therapeutic agents, the…”
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Synergistic Effects of Arsenic Trioxide and Silibinin on Apoptosis and Invasion in Human Glioblastoma U87MG Cell Line by Dizaji, Majid Zaki, Malehmir, Mohsen, Ghavamzadeh, Ardeshir, Alimoghaddam, Kamran, Ghaffari, Seyed H.

“…Patients with glioblastoma multiforme (GBM) have poor therapeutic outcomes despite their current therapy. In an attempt to increase the efficacy of therapy for…”
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DNA methylation in human diseases by Younesian, Samareh, Mohammadi, Mohammad Hossein, Younesian, Ommolbanin, Momeny, Majid, Ghaffari, Seyed H., Bashash, Davood

“…Aberrant epigenetic modifications, particularly DNA methylation, play a critical role in the pathogenesis and progression of human diseases. The current review…”
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Evaluation of hTERT, KRT7, and survivin in urine for noninvasive detection of bladder cancer using real-time PCR by Yahyazadeh, Reza, Bashash, Davood, Ghaffari, Parisa, Kord, Saeid, Safaroghli-Azar, Ava, Ghaffari, Seyed H

“…Transitional cell carcinoma (TCC) of the bladder is the second most common genitourinary malignancy. Because of the low sensitivity of urinary cytology and the…”
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Dacomitinib, a pan-inhibitor of ErbB receptors, suppresses growth and invasive capacity of chemoresistant ovarian carcinoma cells by Momeny, Majid, Zarrinrad, Ghazaleh, Moghaddaskho, Farima, Poursheikhani, Arash, Sankanian, Ghazaleh, Zaghal, Azam, Mirshahvaladi, Shahab, Esmaeili, Fatemeh, Eyvani, Haniyeh, Barghi, Farinaz, Sabourinejad, Zahra, Alishahi, Zivar, Yousefi, Hassan, Ghasemi, Reza, Dardaei, Leila, Bashash, Davood, Chahardouli, Bahram, Dehpour, Ahmad R., Tavakkoly-Bazzaz, Javad, Alimoghaddam, Kamran, Ghavamzadeh, Ardeshir, Ghaffari, Seyed H.

“…Epithelial ovarian cancer (EOC) is the most lethal gynaecological malignancy worldwide. Development of chemoresistance and peritoneal dissemination of EOC…”
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Demethylation and alterations in the expression level of the cell cycle–related genes as possible mechanisms in arsenic trioxide–induced cell cycle arrest in human breast cancer cells by Moghaddaskho, Farima, Eyvani, Haniyeh, Ghadami, Mohsen, Tavakkoly-Bazzaz, Javad, Alimoghaddam, Kamran, Ghavamzadeh, Ardeshir, Ghaffari, Seyed H

“…Arsenic trioxide (As2O3) has been used clinically as an anti-tumor agent. Its mechanisms are mostly considered to be the induction of apoptosis and cell cycle…”
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Arsenic trioxide Alters the MicroRNA Expression Profile of U87 glioblastoma by Shidfar, Fatemeh, Ghaffari, Seyed H, Tavoosidana, Gholamreza, Hosseini, Elham, Alimoghaddam, Kamran, Ghavamzadeh, Ardeshir

“…MicroRNAs (miRNAs) have a major role in cancer pathogenesis, cells growth and apoptosis. We studied the dysregulation of miRNAs after the induction of…”
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Gene amplification and overexpression of Aurora-C in breast and prostate cancer cell lines by Zekri, Ali, Lesan, Vahid, Ghaffari, Seyed H, Tabrizi, Mina Hajifaraj, Modarressi, Mohammad Hussein

“…Human aurora kinases are three highly conserved serine/threonine kinases with regulatory function in chromosome alignment, chromosome segregation, and…”
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Effects of silibinin on cell growth and invasive properties of a human hepatocellular carcinoma cell line, HepG-2, through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation by Momeny, Majid, Khorramizadeh, Mohammad R., Ghaffari, Seyed H., Yousefi, Mehdi, Yekaninejad, Mir S., Esmaeili, Rezvan, Jahanshiri, Zahra, Nooridaloii, Mohammad R.

“…The purpose of the current study is to evaluate the effect of silibinin on human hepatocellular carcinoma HepG-2 cells. Microculture tetrazolium test (MTT…”
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Azidothymidine hinders arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells by induction of p21 and attenuation of G2/M arrest by Hassani, Saeed, Ghaffari, Seyed H., Zaker, Farhad, Mirzaee, Rohellah, Mardani, Hajar, Bashash, Davood, Zekri, Ali, Yousefi, Meysam, Zaghal, Azam, Alimoghaddam, Kamran, Ghavamzadeh, Ardeshir

“…To enhance anticancer efficacy of the arsenic trioxide (ATO), the combination of ATO and azidothymidine (AZT), with convergence anti-telomerase activity, were…”
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