Search Results - "Ghadiri, M Reza"

Directed remodeling of the mouse gut microbiome inhibits the development of atherosclerosis by Chen, Poshen B., Black, Audrey S., Sobel, Adam L., Zhao, Yannan, Mukherjee, Purba, Molparia, Bhuvan, Moore, Nina E., Aleman Muench, German R., Wu, Jiejun, Chen, Weixuan, Pinto, Antonio F. M., Maryanoff, Bruce E., Saghatelian, Alan, Soroosh, Pejman, Torkamani, Ali, Leman, Luke J., Ghadiri, M. Reza

“…The gut microbiome is a malleable microbial community that can remodel in response to various factors, including diet, and contribute to the development of…”
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Peptide Macrocyclization Inspired by Non-Ribosomal Imine Natural Products by Malins, Lara R, deGruyter, Justine N, Robbins, Kevin J, Scola, Paul M, Eastgate, Martin D, Ghadiri, M. Reza, Baran, Phil S

“…A thermodynamic approach to peptide macrocyclization inspired by the cyclization of non-ribosomal peptide aldehydes is presented. The method provides access to…”
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Carbonyl Sulfide:Mediated Prebiotic Formation of Peptides by Leman, Luke, Orgel, Leslie, Ghadiri, M. Reza

“…Almost all discussions of prebiotic chemistry assume that amino acids, nucleotides, and possibly other monomers were first formed on the Earth or brought to it…”
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Design of Self-Assembling Peptide Nanotubes with Delocalized Electronic States by Ashkenasy, Nurit, Horne, W. Seth, Ghadiri, M. Reza

“…Electronically active biomaterials via directed peptide self‐assembly: Redox‐promoted self‐assembly of an eight‐residue cyclic D,L‐α‐peptide bearing four…”
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Boolean Logic Functions of a Synthetic Peptide Network by Ashkenasy, Gonen, Ghadiri, M. Reza

“…Living cells can process rapidly and simultaneously multiple extracellular input signals through the complex networks of evolutionary selected biomolecular…”
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Probing the Bioactive Conformation of an Archetypal Natural Product HDAC Inhibitor with Conformationally Homogeneous Triazole-Modified Cyclic Tetrapeptides by Horne, W. Seth, Olsen, Christian A, Beierle, John M, Montero, Ana, Ghadiri, M. Reza

“…Fooling enzymes with mock amides: Analogues of apicidin, a cyclic-tetrapeptide inhibitor of histone deacetylase (HDAC), were designed with a 1,4- or…”
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Self-Assembling Sequence-Adaptive Peptide Nucleic Acids by Ura, Yasuyuki, Beierle, John M, Leman, Luke J, Orgel, Leslie E, Ghadiri, M. Reza

“…Several classes of nucleic acid analogs have been reported, but no synthetic informational polymer has yet proven responsive to selection pressures under…”
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Mimicry of High-Density Lipoprotein: Functional Peptide–Lipid Nanoparticles Based on Multivalent Peptide Constructs by Zhao, Yannan, Imura, Tomohiro, Leman, Luke J., Curtiss, Linda K., Maryanoff, Bruce E., Ghadiri, M. Reza

“…We describe an approach for engineering peptide–lipid nanoparticles that function similarly to high-density lipoprotein (HDL). Branched, multivalent…”
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A Heterocyclic Peptide Nanotube by Horne, W. Seth, Stout, C. David, Ghadiri, M. Reza

“…An open-ended hollow tubular structure is designed based on hydrogen-bond-directed self-assembly of a chimeric cyclic peptide subunit comprised of alternating…”
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In vivo efficacy of HDL-like nanolipid particles containing multivalent peptide mimetics of apolipoprotein A-I[S] by Zhao, Yannan, Black, Audrey S., Bonnet, David J., Maryanoff, Bruce E., Curtiss, Linda K., Leman, Luke J., Ghadiri, M. Reza

“…We have observed that molecular constructs based on multiple apoA-I mimetic peptides attached to a branched scaffold display promising anti-atherosclerosis…”
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Design of Molecular Logic Devices Based on a Programmable DNA-Regulated Semisynthetic Enzyme by Gianneschi, Nathan C., Ghadiri, M. Reza

“…Informed decisions: Logic operations (AND, OR, NOR) can be performed with an enzyme by tagging it and its inhibitor with single‐strand DNA. By adding…”
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Universal Translators for Nucleic Acid Diagnosis by Picuri, John M, Frezza, Brian M, Ghadiri, M. Reza

“…Defined broadly, molecular translators are constructs that can convert any designated molecular input into a unique output molecule. In particular, the…”
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Design of a Directed Molecular Network by Ashkenasy, Gonen, Jagasia, Reshma, Yadav, Maneesh, Ghadiri, M. Reza, Orgel, Leslie

“…An ability to rationally design complex networks from the bottom up can offer valuable quantitative model systems for use in gaining a deeper appreciation for…”
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A Porous Silicon-Based Optical Interferometric Biosensor by Victor S.-Y. Lin, Motesharei, Kianoush, Dancil, Keiki-Pua S., Sailor, Michael J., Ghadiri, M. Reza

“…A biosensor has been developed based on induced wavelength shifts in the Fabry-Perot fringes in the visible-light reflection spectrum of appropriately…”
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Systemic Antibacterial Activity of Novel Synthetic Cyclic Peptides by DARTOIS, Véronique, SANCHEZ-QUESADA, Jorge, PARR, Thomas R, CABEZAS, Edelmira, CHI, Ellen, DUBBELDE, Chad, DUNN, Carrie, GRANJA, Juan, GRITZEN, Colleen, WEINBERGER, Dana, REZA GHADIRI, M

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Modulating Ion Channel Properties of Transmembrane Peptide Nanotubes through Heteromeric Supramolecular Assemblies by Sánchez-Quesada, Jorge, Isler, Markus P, Ghadiri, M. Reza

“…A selective heteromeric supramolecular assembly process is devised to create functional single channels of altered ion conductance, charge selectivity, and…”
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Conformationally Homogeneous Heterocyclic Pseudotetrapeptides as Three‐Dimensional Scaffolds for Rational Drug Design: Receptor‐Selective Somatostatin Analogues by Beierle, John M., Horne, W. Seth, van Maarseveen, Jan H., Waser, Beatrice, Reubi, Jean Claude, Ghadiri, M. Reza

“…A would‐be amide: A 1,4‐disubstituted 1,2,3‐triazole was used as a surrogate for a trans amide bond to create a library of 16 diastereomeric…”
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Recognizing a Single Base in an Individual DNA Strand: A Step Toward DNA Sequencing in Nanopores by Ashkenasy, Nurit, Sánchez-Quesada, Jorge, Bayley, Hagan, Ghadiri, M. Reza

“…The capture of single strands of DNA inside the α‐hemolysin (α‐HL) transmembrane pore protein upon application of a positive potential leads to single α‐HL⋅DNA…”
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DNA Detection and Signal Amplification via an Engineered Allosteric Enzyme by Saghatelian, Alan, Guckian, Kevin M, Thayer, Desiree A, Ghadiri, M. Reza

“…Rapid, sensitive, and sequence-specific DNA detection can be achieved in one step using an engineered intrasterically regulated enzyme. The semi-synthetic…”
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DNA-Based Photonic Logic Gates:  AND, NAND, and INHIBIT by Saghatelian, Alan, Völcker, Nicolas H, Guckian, Kevin M, Lin, Victor S.-Y, Ghadiri, M. Reza

“…Conventional microprocessors use elementary logic gates to perform complex computational tasks. Mimicking such computational processes using purely molecular…”
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