Search Results - "Ghadieh, Hilda E."

Role of Insulin Clearance in Insulin Action and Metabolic Diseases by Ghadieh, Hilda E, Gastaldelli, Amalia, Najjar, Sonia M

“…The year 2021 marked the centenary of the discovery of insulin [...]…”
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Editorial: Mechanistic and physiological implications of insulin resistance in metabolic diseases by Ghadieh, Hilda E, Infante, Marco, Sponton, Carlos H

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Garlic and Hypertension: Efficacy, Mechanism of Action, and Clinical Implications by Sleiman, Christopher, Daou, Rose-Mary, Al Hazzouri, Antonio, Hamdan, Zahi, Ghadieh, Hilda E, Harbieh, Bernard, Romani, Maya

“…Hypertension is a major risk factor for heart disease and stroke. Garlic has a long history of use in traditional medicine for various conditions, including…”
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Exploring the World of Membrane Proteins: Techniques and Methods for Understanding Structure, Function, and Dynamics by Boulos, Imad, Jabbour, Joy, Khoury, Serena, Mikhael, Nehme, Tishkova, Victoria, Candoni, Nadine, Ghadieh, Hilda E, Veesler, Stéphane, Bassim, Youssef, Azar, Sami, Harb, Frédéric

“…In eukaryotic cells, membrane proteins play a crucial role. They fall into three categories: intrinsic proteins, extrinsic proteins, and proteins that are…”
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Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice by Villa-Pérez, Pablo, Merino, Beatriz, Fernández-Díaz, Cristina M., Cidad, Pilar, Lobatón, Carmen D., Moreno, Alfredo, Muturi, Harrison T., Ghadieh, Hilda E., Najjar, Sonia M., Leissring, Malcolm A., Cózar-Castellano, Irene, Perdomo, Germán

“…The role of insulin-degrading enzyme (IDE), a metalloprotease with high affinity for insulin, in insulin clearance remains poorly understood. OBJECTIVE: This…”
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Aortic Fibrosis in Insulin-Sensitive Mice with Endothelial Cell-Specific Deletion of Ceacam1 Gene by Abu Helal, Raghd, Muturi, Harrison T, Lee, Abraham D, Li, Wei, Ghadieh, Hilda E, Najjar, Sonia M

“…(1) Background: Mice with global deletion developed plaque-like aortic lesions even on C57BL/6J background in the presence of increased endothelial cell…”
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CYP450 Mediates Reactive Oxygen Species Production in a Mouse Model of β-Thalassemia through an Increase in 20-HETE Activity by Bou-Fakhredin, Rayan, Dia, Batoul, Ghadieh, Hilda E, Rivella, Stefano, Cappellini, Maria Domenica, Eid, Assaad A, Taher, Ali T

“…Oxidative damage by reactive oxygen species (ROS) is one of the main contributors to cell injury and tissue damage in thalassemia patients. Recent studies…”
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Exploring the complexities of 1C metabolism: implications in aging and neurodegenerative diseases by Bou Ghanem, Ayman, Hussayni, Yaman, Kadbey, Raghid, Ratel, Yara, Yehya, Shereen, Khouzami, Lara, Ghadieh, Hilda E, Kanaan, Amjad, Azar, Sami, Harb, Frederic

“…The intricate interplay of one-carbon metabolism (OCM) with various cellular processes has garnered substantial attention due to its fundamental implications…”
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Nicotinamide Mononucleotide Prevents Free Fatty Acid-Induced Reduction in Glucose Tolerance by Decreasing Insulin Clearance by Nahle, Ashraf, Joseph, Yemisi Deborah, Pereira, Sandra, Mori, Yusaku, Poon, Frankie, Ghadieh, Hilda E, Ivovic, Aleksandar, Desai, Tejas, Ghanem, Simona S, Asalla, Suman, Muturi, Harrison T, Jentz, Emelien M, Joseph, Jamie W, Najjar, Sonia M, Giacca, Adria

“…The NAD-dependent deacetylase SIRT1 improves β cell function. Accordingly, nicotinamide mononucleotide (NMN), the product of the rate-limiting step in NAD…”
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High-fat diet amplifies renal renin angiotensin system expression, blood pressure elevation, and renal dysfunction caused by Ceacam1 null deletion by Li, Caixia, Culver, Silas A, Quadri, Syed, Ledford, Kelly L, Al-Share, Qusai Y, Ghadieh, Hilda E, Najjar, Sonia M, Siragy, Helmy M

“…Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAMl), a substrate of the insulin receptor tyrosine kinase, regulates insulin action by promoting…”
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Involvement of a battery of investigated genes in lipid droplet pathophysiology and associated comorbidities by Al Harake, Sami N, Abedin, Yasamin, Hatoum, Fatema, Nassar, Nour Zahraa, Ali, Ali, Nassar, Aline, Kanaan, Amjad, Bazzi, Samer, Azar, Sami, Harb, Frederic, Ghadieh, Hilda E

“…Lipid droplets (LDs) are highly specialized energy storage organelles involved in the maintenance of lipid homoeostasis by regulating lipid flux within white…”
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Conditional deletion of CEACAM1 in hepatic stellate cells causes their activation by Muturi, Harrison T., Ghadieh, Hilda E., Asalla, Suman, Lester, Sumona G., Belew, Getachew D., Zaidi, Sobia, Abdolahipour, Raziyeh, Shrestha, Abhishek P., Portuphy, Agnes O., Stankus, Hannah L., Helal, Raghd Abu, Verhulst, Stefaan, Duarte, Sergio, Zarrinpar, Ali, van Grunsven, Leo A., Friedman, Scott L., Schwabe, Robert F., Hinds, Terry D., Kumarasamy, Sivarajan, Najjar, Sonia M.

“…Hepatic CEACAM1 expression declines with advanced hepatic fibrosis stage in patients with metabolic dysfunction-associated steatohepatitis (MASH). Global and…”
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Uncovering the Therapeutic Potential of Lithium Chloride in Type 2 Diabetic Cardiomyopathy: Targeting Tau Hyperphosphorylation and TGF-β Signaling via GSK-3β Inhibition by Abou Assi, Layal, Alkhansa, Sahar, Njeim, Rachel, Ismail, Jaafar, Madi, Mikel, Ghadieh, Hilda E, Al Moussawi, Sarah, Azar, Tanya S, Ayoub, Maurice, Azar, William S, Hamade, Sarah, Nawfal, Rashad, Haddad, Nina-Rossa, Harb, Frederic, Faour, Wissam, Khalil, Mahmoud I, Eid, Assaad A

“…Diabetic cardiomyopathy (DCM) is a major complication of type 2 diabetes mellitus (T2DM) that leads to significant morbidity and mortality. The alteration in…”
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Reno-Protective Effect of GLP-1 Receptor Agonists in Type1 Diabetes: Dual Action on TRPC6 and NADPH Oxidases by Youssef, Natalie, Noureldein, Mohamed, Njeim, Rachel, Ghadieh, Hilda, Harb, Frederic, Azar, Sami, Fares, Nassim, Eid, Assaad

“…Diabetic kidney disease (DKD), a serious diabetic complication, results in podocyte loss and proteinuria through NADPH oxidases (NOX)-mediated ROS production…”
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Regulation of Insulin Clearance by Non-Esterified Fatty Acids by Najjar, Sonia M, Abdolahipour, Raziyeh, Ghadieh, Hilda E, Jahromi, Marziyeh Salehi, Najjar, John A, Abuamreh, Basil A. M, Zaidi, Sobia, Kumarasamy, Sivarajan, Muturi, Harrison T

“…Insulin stores lipid in adipocytes and prevents lipolysis and the release of non-esterified fatty acids (NEFA). Excessive release of NEFA during sustained…”
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Role for hepatic CEACAM1 in regulating fatty acid metabolism along the adipocyte-hepatocyte axis[S] by Russo, Lucia, Ghadieh, Hilda E., Ghanem, Simona S., Al-Share, Qusai Y., Smiley, Zachary N., Gatto-Weis, Cara, Esakov, Emily L., McInerney, Marcia F., Heinrich, Garrett, Tong, Xin, Yin, Lei, Najjar, Sonia M.

“…Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) regulates insulin sensitivity by promoting hepatic insulin clearance and mediating…”
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Influence of intermittent fasting on prediabetes-induced neuropathy: Insights on a novel mechanistic pathway by Dannawi, Maya, Riachi, Mansour E., Haddad, Antony F., El Massry, Mohamed, Haddad, Mary, Moukarzel, Pamela, Harb, Frédéric, Ghadieh, Hilda E., Eid, Assaad A.

“…Peripheral neuropathy (PN) is correlated with obesity and metabolic syndrome. Intermittent fasting (IF) has been described as the cornerstone in the management…”
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Loss of Hepatic CEACAM1: A Unifying Mechanism Linking Insulin Resistance to Obesity and Non-Alcoholic Fatty Liver Disease by Heinrich, Garrett, Ghadieh, Hilda E, Ghanem, Simona S, Muturi, Harrison T, Rezaei, Khadijeh, Al-Share, Qusai Y, Bowman, Thomas A, Zhang, Deqiang, Garofalo, Robert S, Yin, Lei, Najjar, Sonia M

“…The pathogenesis of human non-alcoholic fatty liver disease (NAFLD) remains unclear, in particular in the context of its relationship to insulin resistance and…”
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Insulin Sensitivity Is Retained in Mice with Endothelial Loss of Carcinoembryonic Antigen Cell Adhesion Molecule 1 by Muturi, Harrison T., Khuder, Saja S., Ghadieh, Hilda E., Esakov, Emily L., Noh, Hyelim, Kang, Heejoon, McInerney, Marcia F., Kim, Jason K., Lee, Abraham D., Najjar, Sonia M.

“…CEACAM1 regulates endothelial barrier integrity. Because insulin signaling in extrahepatic target tissues is regulated by insulin transport through the…”
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Immunomodulatory Approaches in Diabetes-Induced Cardiorenal Syndromes by Ammar, Lama A, Nahlawi, Mohamad I, Shayya, Nizar W, Ghadieh, Hilda E, Azar, Nadim S, Harb, Frédéric, Eid, Assaad A

“…Immunomodulatory approaches are defined as all interventions that modulate and curb the immune response of the host rather than targeting the disease itself…”
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