Search Results - "Ghabrial, Amin S"

Whacked and Rab35 polarize dynein-motor-complex-dependent seamless tube growth by Schottenfeld-Roames, Jodi, Ghabrial, Amin S.

“…Seamless tubes are found in Drosophila tracheal terminal cells, but it is still unclear how they grow. Ghabrial and colleagues find that the small GTPase…”
Get full text

Social interactions among epithelial cells during tracheal branching morphogenesis by Krasnow, Mark A, Ghabrial, Amin S

“…Many organs are composed of tubular networks that arise by branching morphogenesis in which cells bud from an epithelium and organize into a tube. Fibroblast…”
Get full text

Seamless Tube Shape Is Constrained by Endocytosis-Dependent Regulation of Active Moesin by Schottenfeld-Roames, Jodi, Rosa, Jeffrey B., Ghabrial, Amin S.

“…Most tubes have seams (intercellular or autocellular junctions that seal membranes together into a tube), but “seamless” tubes also exist [1–3]. In Drosophila,…”
Get full text

An Ichor-dependent apical extracellular matrix regulates seamless tube shape and integrity by Rosa, Jeffrey B, Metzstein, Mark M, Ghabrial, Amin S

“…During sprouting angiogenesis in the vertebrate vascular system, and primary branching in the Drosophila tracheal system, specialized tip cells direct branch…”
Get full text

A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system by Ghabrial, Amin S, Levi, Boaz P, Krasnow, Mark A

“…Many signaling proteins and transcription factors that induce and pattern organs have been identified, but relatively few of the downstream effectors that…”
Get full text

Drosophila talin and integrin genes are required for maintenance of tracheal terminal branches and luminal organization by Levi, Boaz P, Ghabrial, Amin S, Krasnow, Mark A

“…Epithelial tubes that compose many organs are typically long lasting, except under specific developmental and physiological conditions when network remodeling…”
Get full text

Regulation of Archease by the mTOR-vATPase axis by Francis, Deanne, Burguete, Alondra S, Ghabrial, Amin S

“…Larval terminal cells of the Drosophila tracheal system generate extensive branched tubes, requiring a huge increase in apical membrane. We discovered that…”
Get full text

Compensatory branching morphogenesis of stalk cells in the Drosophila trachea by Francis, Deanne, Ghabrial, Amin S

“…Tubes are essential for nutrient transport and gas exchange in multicellular eukaryotes, but how connections between different tube types are maintained over…”
Get full text

Tube continued: morphogenesis of the Drosophila tracheal system by Schottenfeld, Jodi, Song, Yanjun, Ghabrial, Amin S

“…The Drosophila respiratory organ (tracheal system) consists of epithelial tubes, the morphogenesis of which is controlled by distinct sets of signaling…”
Get full text

Focal Defects in Single-Celled Tubes Mutant for Cerebral Cavernous Malformation 3, GCKIII, or NSF2 by Song, Yanjun, Eng, Melissa, Ghabrial, Amin S.

“…Tubes of differing cellular architecture connect into networks. In the Drosophila tracheal system, two tube types connect within single cells (terminal cells);…”
Get full text

Dissection of the Role of CCM Genes in Tubulogenesis Using the Drosophila Tracheal System as a Model by Schweizer Burguete, Alondra B, Ghabrial, Amin S

“…Embryos deficient for an essential gene may show complex phenotypes that reflect pleiotropic functions and non-cell-autonomous requirements for the encoded…”
Get more information

Osmotic regulation of seamless tube growth by Schottenfeld-Roames, Jodi, Ghabrial, Amin S.

“…Most organs are composed of tubes of differing cellular architectures, including intracellular 'seamless' tubes. Two studies examining the morphogenesis of the…”
Get full text

A sweet spot in the FGFR signal transduction pathway by Ghabrial, Amin S

“…The hexosamine biosynthetic pathway, whose end product is UDP-N acetylglucosamine (UDP-GlcNAc), lies at the base of cellular glycosylation pathways, including…”
Get more information

Making and shaping seamless tubes by Ghabrial, Amin S.

Get full text

A Systematic Screen for Tube Morphogenesis and Branching Genes in the Drosophila Tracheal System: e1002087 by Ghabrial, Amin S, Levi, Boaz P, Krasnow, Mark A

“…Many signaling proteins and transcription factors that induce and pattern organs have been identified, but relatively few of the downstream effectors that…”
Get full text

Social interactions among epithelial cells during tracheal branching morphogenesis by Ghabrial, Amin S, Krasnow, Mark A

“…Many organs are composed of tubular networks that arise by branching morphogenesis in which cells bud from an epithelium and organize into a tube. Fibroblast…”
Get full text

Drosophila talin and integrin genes are required for maintenance of tracheal terminal branches and luminal organization

Get full text