Search Results - "Gfeller, Hans"

LC-MS–Based Characterization of the Peptide Reactivity of Chemicals to Improve the In Vitro Prediction of the Skin Sensitization Potential by Natsch, Andreas, Gfeller, Hans

“…A key step in the skin sensitization process is the formation of a covalent adduct between skin sensitizers and endogenous proteins and/or peptides in the…”
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Predicting skin sensitizer potency based on in vitro data from KeratinoSens and kinetic peptide binding: global versus domain-based assessment by Natsch, Andreas, Emter, Roger, Gfeller, Hans, Haupt, Tina, Ellis, Graham

“…Three in vitro methods for the prediction of the skin sensitization hazard have been validated. However, predicting sensitizer potency is a key requirement for…”
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Chemical Reactivity and Skin Sensitization Potential for Benzaldehydes: Can Schiff Base Formation Explain Everything? by Natsch, Andreas, Gfeller, Hans, Haupt, Tina, Brunner, Gerhard

“…Skin sensitizers chemically modify skin proteins rendering them immunogenic. Sensitizing chemicals have been divided into applicability domains according to…”
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A Specific Bacterial Aminoacylase Cleaves Odorant Precursors Secreted in the Human Axilla by Natsch, Andreas, Gfeller, Hans, Gygax, Peter, Schmid, Joachim, Acuna, Gonzalo

“…Human axillary odor is known to be formed upon the action of Corynebacteria sp. on odorless axilla secretions. The known axilla odor determinant…”
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Use of in vitro testing to identify an unexpected skin sensitizing impurity in a commercial product: A case study by Natsch, Andreas, Gfeller, Hans, Emter, Roger, Ellis, Graham

“…Due to regulatory constraints and ethical considerations, the quest for alternatives to animal testing has gained a new momentum. In general, animal welfare…”
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Predicting the Bioconcentration of Fragrance Ingredients by Rainbow Trout Using Measured Rates of in Vitro Intrinsic Clearance by Laue, Heike, Gfeller, Hans, Jenner, Karen J, Nichols, John W, Kern, Susanne, Natsch, Andreas

“…Bioaccumulation in aquatic species is a critical end point in the regulatory assessment of chemicals. Few measured fish bioconcentration factors (BCFs) are…”
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Chemical Basis for the Extreme Skin Sensitization Potency of (E)-4-(Ethoxymethylene)-2-phenyloxazol-5(4H)-one by Natsch, Andreas, Gfeller, Hans, Kuhn, Fabian, Granier, Thierry, Roberts, David W

“…(E)-4-(ethoxymethylene)-2-phenyloxazol-5(4H)-one, commonly referred to as oxazolone, is the most potent skin sensitizer in published databases as determined…”
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Sequestration of Veratrum alkaloids by specialist Rhadinoceraea nodicornis Konow (Hymenoptera, Tenthredinidae) and its ecoethological implications by Schaffner, U. (University of Bern, Bern, Switzerland.), Boeve, J.L, Gfeller, H, Schlunegger, U.P

“…The larvae of the specialist sawfly Rhadinoceraea nodicornis Konow (Hymenoptera, Tenthredinidae) store in their hemolymph ceveratrum alkaloids originating from…”
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The secretion of the ventral glands in Hoplocampa sawfly larvae by Boevé, Jean-Luc, Gfeller, Hans, P. Schlunegger, Urs, Francke, Wittko

“…The defensive secretion of the ventral glands of both species, Hoplocampa testudinea and H. flava is mainly composed of acetogenins. Major compounds are (…”
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Gas chromatographic-mass spectrometric identification of betaine lipids in Chroomonas salina by Eichenberger, Waldemar, Gfeller, Hans, Grey, Patrick, Gribi, Corinne, James Henderson, R.

“…The betaine lipids diacylglycerylhydroxymethyltrimethyl-β-alanine (DGTA) and diacylglyceryltrimethylhomoserine (DGTS) can be identified by derivatization of…”
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Phosphatidyl- O-[ N-(2-Hydroxyethyl)Glycine] (PHEG), a New Glycerophospholipid from Brown Algae (Phaeophyceae) by Eichenbergeri, Waldemar, Bigler, Peter, Gfeller, Hans, Gribi, Corinne, Schmid, Christine E.

“…The phosphoglyceride phosphatidyl- O-[ N(2-hydroxyethyl)glycine] (PHEG) has been isolated from Fucus serratus L. (Fucales, Phaeophyceae) and its structure…”
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Sequestration ofVeratrum alkaloids by specialistRhadinoceraea nodicornis konow (Hymenoptera, Tenthredinidae) and its ecoethological implications by Schaffner, U, Boevé, J L, Gfeller, H, Schlunegger, U P

“…The larvae of the specialist sawflyRhadinoceraea nodicornis Konow (Hymenoptera, Tenthredinidae) store in their hemolymph ceveratrum alkaloids originating from…”
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