Search Results - "Geyer, Philipp"

Revisiting biomarker discovery by plasma proteomics by Geyer, Philipp E, Holdt, Lesca M, Teupser, Daniel, Mann, Matthias

“…Clinical analysis of blood is the most widespread diagnostic procedure in medicine, and blood biomarkers are used to categorize patients and to support…”
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BoxCar acquisition method enables single-shot proteomics at a depth of 10,000 proteins in 100 minutes by Meier, Florian, Geyer, Philipp E., Virreira Winter, Sebastian, Cox, Juergen, Mann, Matthias

“…Great advances have been made in sensitivity and acquisition speed on the Orbitrap mass analyzer, enabling increasingly deep proteome coverage. However, these…”
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Loss-less Nano-fractionator for High Sensitivity, High Coverage Proteomics by Kulak, Nils A., Geyer, Philipp E., Mann, Matthias

“…Recent advances in mass spectrometry (MS)-based proteomics now allow very deep coverage of cellular proteomes. To achieve near-comprehensive identification and…”
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Plasma Proteome Profiling to Assess Human Health and Disease by Geyer, Philipp E, Kulak, Nils A, Pichler, Garwin, Holdt, Lesca M, Teupser, Daniel, Mann, Matthias

“…Proteins in the circulatory system mirror an individual's physiology. In daily clinical practice, protein levels are generally determined using single-protein…”
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Noninvasive proteomic biomarkers for alcohol-related liver disease by Niu, Lili, Thiele, Maja, Geyer, Philipp E., Rasmussen, Ditlev Nytoft, Webel, Henry Emanuel, Santos, Alberto, Gupta, Rajat, Meier, Florian, Strauss, Maximilian, Kjaergaard, Maria, Lindvig, Katrine, Jacobsen, Suganya, Rasmussen, Simon, Hansen, Torben, Krag, Aleksander, Mann, Matthias

“…Alcohol-related liver disease (ALD) is a major cause of liver-related death worldwide, yet understanding of the three key pathological features of the…”
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Region and cell-type resolved quantitative proteomic map of the human heart by Doll, Sophia, Dreßen, Martina, Geyer, Philipp E., Itzhak, Daniel N., Braun, Christian, Doppler, Stefanie A., Meier, Florian, Deutsch, Marcus-Andre, Lahm, Harald, Lange, Rüdiger, Krane, Markus, Mann, Matthias

“…The heart is a central human organ and its diseases are the leading cause of death worldwide, but an in-depth knowledge of the identity and quantity of its…”
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A knowledge graph to interpret clinical proteomics data by Santos, Alberto, Colaço, Ana R., Nielsen, Annelaura B., Niu, Lili, Strauss, Maximilian, Geyer, Philipp E., Coscia, Fabian, Albrechtsen, Nicolai J. Wewer, Mundt, Filip, Jensen, Lars Juhl, Mann, Matthias

“…Implementing precision medicine hinges on the integration of omics data, such as proteomics, into the clinical decision-making process, but the quantity and…”
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Profiling the human intestinal environment under physiological conditions by Shalon, Dari, Culver, Rebecca Neal, Grembi, Jessica A., Folz, Jacob, Treit, Peter V., Shi, Handuo, Rosenberger, Florian A., Dethlefsen, Les, Meng, Xiandong, Yaffe, Eitan, Aranda-Díaz, Andrés, Geyer, Philipp E., Mueller-Reif, Johannes B., Spencer, Sean, Patterson, Andrew D., Triadafilopoulos, George, Holmes, Susan P., Mann, Matthias, Fiehn, Oliver, Relman, David A., Huang, Kerwyn Casey

“…The spatiotemporal structure of the human microbiome 1 , 2 , proteome 3 and metabolome 4 , 5 reflects and determines regional intestinal physiology and may…”
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The proteome landscape of the kingdoms of life by Müller, Johannes B., Geyer, Philipp E., Colaço, Ana R., Treit, Peter V., Strauss, Maximilian T., Oroshi, Mario, Doll, Sophia, Virreira Winter, Sebastian, Bader, Jakob M., Köhler, Niklas, Theis, Fabian, Santos, Alberto, Mann, Matthias

“…Proteins carry out the vast majority of functions in all biological domains, but for technological reasons their large-scale investigation has lagged behind…”
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Plasma Proteome Profiling to detect and avoid sample‐related biases in biomarker studies by Geyer, Philipp E, Voytik, Eugenia, Treit, Peter V, Doll, Sophia, Kleinhempel, Alisa, Niu, Lili, Müller, Johannes B, Buchholtz, Marie‐Luise, Bader, Jakob M, Teupser, Daniel, Holdt, Lesca M, Mann, Matthias

“…Plasma and serum are rich sources of information regarding an individual's health state, and protein tests inform medical decision making. Despite major…”
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Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease by Bader, Jakob M, Geyer, Philipp E, Müller, Johannes B, Strauss, Maximilian T, Koch, Manja, Leypoldt, Frank, Koertvelyessy, Peter, Bittner, Daniel, Schipke, Carola G, Incesoy, Enise I, Peters, Oliver, Deigendesch, Nikolaus, Simons, Mikael, Jensen, Majken K, Zetterberg, Henrik, Mann, Matthias

“…Neurodegenerative diseases are a growing burden, and there is an urgent need for better biomarkers for diagnosis, prognosis, and treatment efficacy. Structural…”
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Proteomics reveals the effects of sustained weight loss on the human plasma proteome by Geyer, Philipp E, Wewer Albrechtsen, Nicolai J, Tyanova, Stefka, Grassl, Niklas, Iepsen, Eva W, Lundgren, Julie, Madsbad, Sten, Holst, Jens J, Torekov, Signe S, Mann, Matthias

“…Sustained weight loss is a preferred intervention in a wide range of metabolic conditions, but the effects on an individual's health state remain ill‐defined…”
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Plasma proteome profiling discovers novel proteins associated with non‐alcoholic fatty liver disease by Niu, Lili, Geyer, Philipp E, Wewer Albrechtsen, Nicolai J, Gluud, Lise L, Santos, Alberto, Doll, Sophia, Treit, Peter V, Holst, Jens J, Knop, Filip K, Vilsbøll, Tina, Junker, Anders, Sachs, Stephan, Stemmer, Kerstin, Müller, Timo D, Tschöp, Matthias H, Hofmann, Susanna M, Mann, Matthias

“…Non‐alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis with limited treatment options. As the liver secretes…”
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Mass Spectrometry-Based Plasma Proteomics: Considerations from Sample Collection to Achieving Translational Data by Ignjatovic, Vera, Geyer, Philipp E, Palaniappan, Krishnan K, Chaaban, Jessica E, Omenn, Gilbert S, Baker, Mark S, Deutsch, Eric W, Schwenk, Jochen M

“…The proteomic analysis of human blood and blood-derived products (e.g., plasma) offers an attractive avenue to translate research progress from the laboratory…”
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High‐resolution serum proteome trajectories in COVID‐19 reveal patient‐specific seroconversion by Geyer, Philipp E, Arend, Florian M, Doll, Sophia, Louiset, Marie‐Luise, Virreira Winter, Sebastian, Müller‐Reif, Johannes B, Torun, Furkan M, Weigand, Michael, Eichhorn, Peter, Bruegel, Mathias, Strauss, Maximilian T, Holdt, Lesca M, Mann, Matthias, Teupser, Daniel

“…A deeper understanding of COVID‐19 on human molecular pathophysiology is urgently needed as a foundation for the discovery of new biomarkers and therapeutic…”
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Plasma Proteomes Can Be Reidentifiable and Potentially Contain Personally Sensitive and Incidental Findings by Geyer, Philipp E., Mann, Sebastian Porsdam, Treit, Peter V., Mann, Matthias

“…The goal of clinical proteomics is to identify, quantify, and characterize proteins in body fluids or tissue to assist diagnosis, prognosis, and treatment of…”
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Ethical Principles, Constraints, and Opportunities in Clinical Proteomics by Mann, Sebastian Porsdam, Treit, Peter V., Geyer, Philipp E., Omenn, Gilbert S., Mann, Matthias

“…Recent advances in MS-based proteomics have vastly increased the quality and scope of biological information that can be derived from human samples. These…”
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Advances and Utility of the Human Plasma Proteome by Deutsch, Eric W, Omenn, Gilbert S, Sun, Zhi, Maes, Michal, Pernemalm, Maria, Palaniappan, Krishnan K, Letunica, Natasha, Vandenbrouck, Yves, Brun, Virginie, Tao, Sheng-ce, Yu, Xiaobo, Geyer, Philipp E, Ignjatovic, Vera, Moritz, Robert L, Schwenk, Jochen M

“…The study of proteins circulating in blood offers tremendous opportunities to diagnose, stratify, or possibly prevent diseases. With recent technological…”
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Dynamic human liver proteome atlas reveals functional insights into disease pathways by Niu, Lili, Geyer, Philipp E, Gupta, Rajat, Santos, Alberto, Meier, Florian, Doll, Sophia, Wewer Albrechtsen, Nicolai J, Klein, Sabine, Ortiz, Cristina, Uschner, Frank E, Schierwagen, Robert, Trebicka, Jonel, Mann, Matthias

“…Deeper understanding of liver pathophysiology would benefit from a comprehensive quantitative proteome resource at cell type resolution to predict outcome and…”
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Proteomics for blood biomarker exploration of severe mental illness: pitfalls of the past and potential for the future by Comes, Ashley L., Papiol, Sergi, Mueller, Thorsten, Geyer, Philipp E., Mann, Matthias, Schulze, Thomas G.

“…Recent improvements in high-throughput proteomic approaches are likely to constitute an essential advance in biomarker discovery, holding promise for improved…”
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