Search Results - "Geyer, MA"

Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist by Vanover, Kimberly E, Weiner, David M, Makhay, Malath, Veinbergs, Isaac, Gardell, Luis R, Lameh, Jelveh, Del Tredici, Andria L, Piu, Fabrice, Schiffer, Hans H, Ott, Thomas R, Burstein, Ethan S, Uldam, Allan K, Thygesen, Mikkel B, Schlienger, Nathalie, Andersson, Carl Magnus, Son, Thomas Y, Harvey, Scott C, Powell, Susan B, Geyer, Mark A, Tolf, Bo-Ragner, Brann, Mark R, Davis, Robert E

“…The in vitro and in vivo pharmacological properties of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide…”
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Developing treatments for cognitive deficits in schizophrenia: The challenge of translation by Young, JW, Geyer, MA

“…Schizophrenia is a life-long debilitating mental disorder affecting tens of millions of people worldwide. The serendipitous discovery of antipsychotics focused…”
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The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity by Henry, S.A, Lehmann-Masten, V, Gasparini, F, Geyer, M.A, Markou, A

“…Phencyclidine (PCP), a non-competitive antagonist of ionotropic N-methyl- D-aspartate (NMDA) receptors, produces psychotomimetic effects, such as a disruption…”
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Low dose ketamine increases prepulse inhibition in healthy men by Abel, Kathryn M, Allin, Matthew P.G, Hemsley, David R, Geyer, Mark A

“…The N-methyl- d-aspartate (NMDA) antagonist, ketamine, produces neurobehavioural symptoms that mimic aspects of schizophrenia. Prepulse inhibition (PPI) of the…”
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Plastic Mulch Films in Agriculture: Their Use, Environmental Problems, Recycling and Alternatives by Kotaiba Salama, Martin Geyer

“…Agricultural plastic mulching is an important horticultural process for increasing crop yields because it preserves soil moisture, soil temperature, and…”
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Measurement of Water Vapor Condensation on Apple Surfaces during Controlled Atmosphere Storage by Linke, Manfred, Praeger, Ulrike, Neuwald, Daniel A, Geyer, Martin

“…Apples are stored at temperatures close to 0 °C and high relative humidity (up to 95%) under controlled atmosphere conditions. Under these conditions, the…”
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Habituation revisited: An updated and revised description of the behavioral characteristics of habituation by Rankin, Catharine H., Abrams, Thomas, Barry, Robert J., Bhatnagar, Seema, Clayton, David F., Colombo, John, Coppola, Gianluca, Geyer, Mark A., Glanzman, David L., Marsland, Stephen, McSweeney, Frances K., Wilson, Donald A., Wu, Chun-Fang, Thompson, Richard F.

“…The most commonly cited descriptions of the behavioral characteristics of habituation come from two papers published almost 40 years ago [Groves, P. M., &…”
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Prepulse inhibition and genetic mouse models of schizophrenia by Powell, Susan B., Zhou, Xianjin, Geyer, Mark A.

“…Mutant mouse models related to schizophrenia have been based primarily on the pathophysiology of schizophrenia, the known effects of antipsychotic drugs, and…”
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A Neurobehavioral Systems Analysis of Adult Rats Exposed to Methylazoxymethanol Acetate on E17: Implications for the Neuropathology of Schizophrenia by Moore, Holly, Jentsch, J. David, Ghajarnia, Mehdi, Geyer, Mark A., Grace, Anthony A.

“…As a test of plausibility for the hypothesis that schizophrenia can result from abnormal brain, especially cerebral cortical, development, these studies…”
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Survival benefit of overweight patients undergoing MitraClip® procedure in comparison to normal‐weight patients by Keller, Karsten, Geyer, Martin, Hobohm, Lukas, Tamm, Alexander R., Kreidel, Felix, Ruf, Tobias F., Hell, Michaela, Schmitt, Volker H., Bachmann, Kevin, Born, Sonja, Schulz, Eberhard, Münzel, Thomas, Bardeleben, Ralph S.

“…Background The number of MitraClip® implantations increased significantly in recent years. Data regarding the impact of weight class on survival are sparse…”
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Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies by Braff, D L, Geyer, M A, Swerdlow, N R

“…Since the mid-1970s, cross-species translational studies of prepulse inhibition (PPI) have increased at an astounding pace as the value of this…”
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Animal behavior models of the mechanisms underlying antipsychotic atypicality by Geyer, Mark A., Ellenbroek, Bart

“…This review describes the animal behavior models that provide insight into the mechanisms underlying the critical differences between the actions of typical…”
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Delayed procedural learning in alpha 7-nicotinic acetylcholine receptor knockout mice by Young, J W, Meves, J M, Tarantino, I S, Caldwell, S, Geyer, MA

“…The alpha 7-nicotinic acetylcholine receptor (nAChR) has long been a procognitive therapeutic target to treat schizophrenia. Evidence on the role of this…”
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Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges by Swerdlow, N R, Geyer, M A, Braff, D L

“…Sensorimotor gating of the startle reflex can be assessed across species, using similar stimuli to elicit similar responses. Prepulse inhibition (PPI), a…”
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Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review by Geyer, M A, Krebs-Thomson, K, Braff, D L, Swerdlow, N R

“…Patients with schizophrenia exhibit deficits in an operational measure of sensorimotor gating: prepulse inhibition (PPI) of startle. Similar deficits in PPI…”
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Deficits in prepulse inhibition and habituation in never-medicated, first-episode schizophrenia by Ludewig, Katja, Geyer, Mark A, Vollenweider, Franz X

“…Prepulse inhibition (PPI) is the normal suppression of the startle reflex when an intense startling stimulus is preceded by a barely detectable prepulse…”
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Echocardiography-guided subxiphoidal transapical TAVR in a challenging anatomy: a case report by Beiras-Fernandez, Andres, Kornberger, Angela, Geyer, Martin, Tamm, Alexander, von Bardeleben, Ralph Stephan

“…Abstract Background Transcatheter aortic valve replacement (TAVR) via an antegrade transapical access (TA-TAVR) is largely reserved to cases not amenable to…”
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Bioresorbable vascular scaffolds for percutaneous treatment of chronic total coronary occlusions: a meta-analysis by Polimeni, Alberto, Anadol, Remzi, Münzel, Thomas, Geyer, Martin, De Rosa, Salvatore, Indolfi, Ciro, Gori, Tommaso

“…BRS represent a new approach to treating coronary artery disease. Beneficial properties of BRS regarding the restoration of vasomotility after resorption make…”
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Mouse genetic models for prepulse inhibition: an early review by GEYER, M. A, MCLLWAIN, K. L, PAYLOR, R

“…Prepulse inhibition (PPI) is the phenomenon in which a weak prepulse stimulus attenuates the response to a subsequent startling stimulus. Patients with…”
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A systems model of altered consciousness: integrating natural and drug-induced psychoses by Vollenweider, Franz X, Geyer, Mark A

“…Increasing evidence from neuroimaging and behavioral studies suggests that functional disturbances within cortico-striato-thalamic pathways are critical to…”
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