Search Results - "Geyer, M. A."

Studying Physics during the COVID-19 Pandemic: Student Assessments of Learning Achievement, Perceived Effectiveness of Online Recitations, and Online Laboratories by Klein, P, Ivanjek, L, Dahlkemper, M. N, Jelicic, K, Geyer, M.-A, Küchemann, S, Susac, A

“…The COVID-19 pandemic has significantly affected the education system worldwide, which was forced to respond with a sudden shift to distance learning. While…”
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Developing treatments for cognitive deficits in schizophrenia: The challenge of translation by Young, JW, Geyer, MA

“…Schizophrenia is a life-long debilitating mental disorder affecting tens of millions of people worldwide. The serendipitous discovery of antipsychotics focused…”
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Identification of blood biomarkers for psychosis using convergent functional genomics by Kurian, S M, Le-Niculescu, H, Patel, S D, Bertram, D, Davis, J, Dike, C, Yehyawi, N, Lysaker, P, Dustin, J, Caligiuri, M, Lohr, J, Lahiri, D K, Nurnberger, J I, Faraone, S V, Geyer, M A, Tsuang, M T, Schork, N J, Salomon, D R, Niculescu, A B

“…There are to date no objective clinical laboratory blood tests for psychotic disease states. We provide proof of principle for a convergent functional genomics…”
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Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach by OGDEN, C. A, RICH, M. E, SCHORK, N. J, PAULUS, M. P, GEYER, M. A, LOHR, J. B, KUCZENSKI, R, NICULESCU, A. B

“…Identifying genes for bipolar mood disorders through classic genetics has proven difficult. Here, we present a comprehensive convergent approach that…”
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Mouse genetic models for prepulse inhibition: an early review by GEYER, M. A, MCLLWAIN, K. L, PAYLOR, R

“…Prepulse inhibition (PPI) is the phenomenon in which a weak prepulse stimulus attenuates the response to a subsequent startling stimulus. Patients with…”
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Studying Physics during the COVID-19 Pandemic: Student Perceptions on Synchronous and Asynchronous Course Formats and Implications for the Future by Ivanjek, L, Klein, P, Geyer, M.-A, Küchemann, S, Jelicic, K, Dahlkemper, M. N, Susac, A

“…To investigate how physics students perceived the sudden shift to online learning at the beginning of COVID-19 pandemic, 18 semistructured interviews were…”
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Deficits in parvalbumin and calbindin immunoreactive cells in the hippocampus of isolation reared rats by Harte, M K, Powell, S B, Swerdlow, N R, Geyer, M A, Reynolds, G P

“…Post-mortem studies have provided evidence for abnormalities of the gamma-aminobutyric acid (GABA)-ergic system in schizophrenia. The calcium-binding proteins…”
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Delayed procedural learning in α7‐nicotinic acetylcholine receptor knockout mice by Young, J. W., Meves, J. M., Tarantino, I. S., Caldwell, S., Geyer, M. A.

“…The α7‐nicotinic acetylcholine receptor (nAChR) has long been a procognitive therapeutic target to treat schizophrenia. Evidence on the role of this receptor…”
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Assessment of a prepulse inhibition deficit in a mutant mouse lacking mGlu5 receptors by BRODY, S. A, DULAWA, S. C, CONQUET, F, GEYER, M. A

“…The glutamate hypothesis of schizophrenia derived from evidence that phencyclidine, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist, produces…”
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Using an Animal Model of Deficient Sensorimotor Gating to Study the Pathophysiology and New Treatments of Schizophrenia by Swerdlow, Neal R, Geyer, Mark A

“…Certain animal models can greatly enhance our understanding of the neurobiology of schizophrenia and can be used to predict the antipsychotic activity of…”
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Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies by Braff, D L, Geyer, M A, Swerdlow, N R

“…Since the mid-1970s, cross-species translational studies of prepulse inhibition (PPI) have increased at an astounding pace as the value of this…”
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The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity by Henry, S.A, Lehmann-Masten, V, Gasparini, F, Geyer, M.A, Markou, A

“…Phencyclidine (PCP), a non-competitive antagonist of ionotropic N-methyl- D-aspartate (NMDA) receptors, produces psychotomimetic effects, such as a disruption…”
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Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges by Swerdlow, N R, Geyer, M A, Braff, D L

“…Sensorimotor gating of the startle reflex can be assessed across species, using similar stimuli to elicit similar responses. Prepulse inhibition (PPI), a…”
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Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review by Geyer, M A, Krebs-Thomson, K, Braff, D L, Swerdlow, N R

“…Patients with schizophrenia exhibit deficits in an operational measure of sensorimotor gating: prepulse inhibition (PPI) of startle. Similar deficits in PPI…”
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Convergent functional genomics of anxiety disorders: translational identification of genes, biomarkers, pathways and mechanisms by Le-Niculescu, H, Balaraman, Y, Patel, S D, Ayalew, M, Gupta, J, Kuczenski, R, Shekhar, A, Schork, N, Geyer, M A, Niculescu, A B

“…Anxiety disorders are prevalent and disabling yet understudied from a genetic standpoint, compared with other major psychiatric disorders such as bipolar…”
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Impaired postnatal development of hippocampal dentate gyrus in Sp4 null mutant mice by Zhou, X., Qyang, Y., Kelsoe, J. R., Masliah, E., Geyer, M. A.

“…Sp4, a member of the Sp1 family of transcription factors, is expressed restrictively in the developing nervous system and abundantly in the hippocampus…”
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Towards understanding the schizophrenia code: An expanded convergent functional genomics approach by Le-Niculescu, H., Balaraman, Y., Patel, S., Tan, J., Sidhu, K., Jerome, R.E., Edenberg, H.J., Kuczenski, R., Geyer, M.A., Nurnberger Jr, J.I., Faraone, S.V., Tsuang, M.T., Niculescu, A.B.

“…Identifying genes for schizophrenia through classical genetic approaches has proven arduous. Here, we present a comprehensive convergent analysis that…”
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Phenomic, Convergent Functional Genomic, and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism by Le-Niculescu, H., McFarland, M.J., Ogden, C.A., Balaraman, Y., Patel, S., Tan, J., Rodd, Z.A., Paulus, M., Geyer, M.A., Edenberg, H.J., Glatt, S.J., Faraone, S.V., Nurnberger, J.I., Kuczenski, R., Tsuang, M.T., Niculescu, A.B.

“…We had previously identified the clock gene D‐box binding protein (Dbp) as a potential candidate gene for bipolar disorder and for alcoholism, using a…”
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Effect of antipsychotic treatment on the prepulse inhibition deficit of mGluR5 knockout mice by BRODY, S. A, CONQUET, F, GEYER, M. A

“…Prepulse inhibition of the startle response (PPI), a model of sensorimotor gating, is deficient in persons with schizophrenia. In rodents, the reversal of…”
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5-hydroxytryptamine2A receptor inverse agonists as antipsychotics by Weiner, D M, Burstein, E S, Nash, N, Croston, G E, Currier, E A, Vanover, K E, Harvey, S C, Donohue, E, Hansen, H C, Andersson, C M, Spalding, T A, Gibson, D F, Krebs-Thomson, K, Powell, S B, Geyer, M A, Hacksell, U, Brann, M R

“…We have used a cell-based functional assay to define the pharmacological profiles of a wide range of central nervous system active compounds as agonists,…”
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