Search Results - "Gey van Pittius, Nicolaas C."

Geospatial distribution of Mycobacterium tuberculosis genotypes in Africa by Chihota, Violet N, Niehaus, Antoinette, Streicher, Elizabeth M, Wang, Xia, Sampson, Samantha L, Mason, Peter, Källenius, Gunilla, Mfinanga, Sayoki G, Pillay, Marnomorney, Klopper, Marisa, Kasongo, Webster, Behr, Marcel A, Gey van Pittius, Nicolaas C, van Helden, Paul D, Couvin, David, Rastogi, Nalin, Warren, Robin M

“…To investigate the distribution of Mycobacterium tuberculosis genotypes across Africa. The SITVIT2 global repository and PUBMED were searched for spoligotype…”
Get full text

Type VII secretion - mycobacteria show the way by Bitter, Wilbert, Abdallah, Abdallah M, Gey van Pittius, Nicolaas C, DiGiuseppe Champion, Patricia A, Cox, Jeffery, Luirink, Joen, Vandenbroucke-Grauls, Christina M. J. E, Appelmelk, Ben J

“…Recent evidence shows that mycobacteria have developed novel and specialized secretion systems for the transport of extracellular proteins across their…”
Get full text

Novel Mycobacterium tuberculosis complex pathogen, M. mungi by Alexander, Kathleen A, Laver, Pete N, Michel, Anita L, Williams, Mark, van Helden, Paul D, Warren, Robin M, Gey van Pittius, Nicolaas C

“…Seven outbreaks involving increasing numbers of banded mongoose troops and high death rates have been documented. We identified a Mycobacterium tuberculosis…”
Get full text

Rifampicin Reduces Susceptibility to Ofloxacin in Rifampicin-resistant Mycobacterium tuberculosis through Efflux by LOUW, Gail E, WARREN, Robin M, VICTOR, Thomas C, GEY VAN PITTIUS, Nicolaas C, LEON, Rosalba, JIMENEZ, Adelina, HERNANDEZ-PANDO, Rogelio, MCEVOY, Christopher R. E, GROBBELAAR, Melanie, MURRAY, Megan, VAN HELDEN, Paul D

“…Central dogma suggests that rifampicin resistance in Mycobacterium tuberculosis develops solely through rpoB gene mutations. To determine whether rifampicin…”
Get full text

PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the type VII secretion system ESX‐5 by Abdallah, Abdallah M., Verboom, Theo, Weerdenburg, Eveline M., Gey van Pittius, Nicolaas C., Mahasha, Phetole W., Jiménez, Connie, Parra, Marcela, Cadieux, Nathalie, Brennan, Michael J., Appelmelk, Ben J., Bitter, Wilbert

“…Summary ESX‐5 is one of the five type VII secretion systems found in mycobacteria. These secretion systems are also known as ESAT‐6‐like secretion systems…”
Get full text

Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages by Phelan, Jody E, Coll, Francesc, Bergval, Indra, Anthony, Richard M, Warren, Rob, Sampson, Samantha L, Gey van Pittius, Nicolaas C, Glynn, Judith R, Crampin, Amelia C, Alves, Adriana, Bessa, Theolis Barbosa, Campino, Susana, Dheda, Keertan, Grandjean, Louis, Hasan, Rumina, Hasan, Zahra, Miranda, Anabela, Moore, David, Panaiotov, Stefan, Perdigao, Joao, Portugal, Isabel, Sheen, Patricia, de Oliveira Sousa, Erivelton, Streicher, Elizabeth M, van Helden, Paul D, Viveiros, Miguel, Hibberd, Martin L, Pain, Arnab, McNerney, Ruth, Clark, Taane G

“…Approximately 10% of the Mycobacterium tuberculosis genome is made up of two families of genes that are poorly characterized due to their high GC content and…”
Get full text

Novel cause of tuberculosis in meerkats, South Africa by Parsons, Sven D C, Drewe, Julian A, Gey van Pittius, Nicolaas C, Warren, Robin M, van Helden, Paul D

“…The organism that causes tuberculosis in meerkats (Suricata suricatta) has been poorly characterized. Our genetic analysis showed it to be a novel member of…”
Get full text

Systematic genetic nomenclature for type VII secretion systems by Bitter, Wilbert, Houben, Edith N G, Bottai, Daria, Brodin, Priscille, Brown, Eric J, Cox, Jeffery S, Derbyshire, Keith, Fortune, Sarah M, Gao, Lian-Yong, Liu, Jun, Gey van Pittius, Nicolaas C, Pym, Alexander S, Rubin, Eric J, Sherman, David R, Cole, Stewart T, Brosch, Roland

“…  [...]we would like to emphasize that the introduction of a uniform gene nomenclature for other secretion systems in Gram-negative bacteria (type II, type…”
Get full text

Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions by Gey van Pittius, Nicolaas C, Sampson, Samantha L, Lee, Hyeyoung, Kim, Yeun, van Helden, Paul D, Warren, Robin M

“…The PE and PPE multigene families of Mycobacterium tuberculosis comprise about 10% of the coding potential of the genome. The function of the proteins encoded…”
Get full text

Frequent Homologous Recombination Events in Mycobacterium tuberculosis PE/PPE Multigene Families: Potential Role in Antigenic Variability by KARBOUL, Anis, MAZZA, Alberto, GEY VAN PITTIUS, Nicolaas C, HO, John L, BROUSSEAU, Roland, MARDASSI, Helmi

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Clinical Relevance of Nontuberculous Mycobacteria Isolated from Sputum in a Gold Mining Workforce in South Africa: An Observational, Clinical Study by Grant, Alison D., van Helden, Paul D., Lewis, James J., Fielding, Katherine L., Gey van Pittius, Nicolaas C., Chihota, Violet N., van Halsema, Clare L., Churchyard, Gavin J.

“…Background. The clinical relevance of nontuberculous mycobacteria (NTM), detected by liquid more than solid culture in sputum specimens from a South African…”
Get full text

Characterization of Mycobacterium orygis by Gey van Pittius, Nicolaas C, van Helden, Paul D, Warren, Robin M

Get full text

Application of Sensitive and Specific Molecular Methods To Uncover Global Dissemination of the Major RDRio Sublineage of the Latin American-Mediterranean Mycobacterium tuberculosis Spoligotype Family by Gibson, Andrea L, Huard, Richard C, Gey van Pittius, Nicolaas C, Lazzarini, Luiz Claudio Oliveira, Driscoll, Jeffrey, Kurepina, Natalia, Zozio, Thierry, Sola, Christophe, Spindola, Silvana Miranda, Kritski, Afrânio L, Fitzgerald, Daniel, Kremer, Kristin, Mardassi, Helmi, Chitale, Poonam, Brinkworth, Jessica, Garcia de Viedma, Dario, Gicquel, Brigitte, Pape, Jean W, van Soolingen, Dick, Kreiswirth, Barry N, Warren, Robin M, van Helden, Paul D, Rastogi, Nalin, Suffys, Philip N, Lapa e Silva, Jose, Ho, John L

“…The Latin American-Mediterranean (LAM) family of Mycobacterium tuberculosis is believed to be the cause of ~15% of tuberculosis cases worldwide. Previously, we…”
Get full text

The role of IS6110 in the evolution of Mycobacterium tuberculosis by McEvoy, Christopher R E, Falmer, Alecia A, Gey van Pittius, Nicolaas C, Victor, Thomas C, van Helden, Paul D, Warren, Robin M

“…Members of the Mycobacterium tuberculosis complex contain the transposable element IS6110 which, due to its high numerical and positional polymorphism, has…”
Get full text

Evaluation of the Capilia TB Assay for Culture Confirmation of Mycobacterium tuberculosis Infections in Zambia and South Africa by Muyoyeta, Monde, de Haas, Petra E.W, Mueller, Dirk H, van Helden, Paul D, Mwenge, Lawrence, Schaap, Ab, Kruger, Clarissa, Gey van Pittius, Nicolaas C, Lawrence, Katherine, Beyers, Nulda, Godfrey-Faussett, Peter, Ayles, Helen

“…The performance and cost of the Capilia TB assay were evaluated for use in a resource-limited setting. The sensitivity and specificity were 99.6% and 99.5%,…”
Get full text

The complex architecture of mycobacterial promoters by Newton-Foot, Mae, Gey van Pittius, Nicolaas C

“…Summary The genus Mycobacterium includes a variety of species with differing phenotypic properties, including growth rate, pathogenicity and environment- and…”
Get full text

Proteogenomic Investigation of Strain Variation in Clinical Mycobacterium tuberculosis Isolates by Heunis, Tiaan, Dippenaar, Anzaan, Warren, Robin M, van Helden, Paul D, van der Merwe, Ruben G, Gey van Pittius, Nicolaas C, Pain, Arnab, Sampson, Samantha L, Tabb, David L

“…Mycobacterium tuberculosis consists of a large number of different strains that display unique virulence characteristics. Whole-genome sequencing has revealed…”
Get full text

Comparative Genomics and Proteomic Analysis of Four Non-tuberculous Mycobacterium Species and Mycobacterium tuberculosis Complex: Occurrence of Shared Immunogenic Proteins by Gcebe, Nomakorinte, Michel, Anita, Gey van Pittius, Nicolaas C, Rutten, Victor

“…The Esx and PE/PPE families of proteins are among the most immunodominant mycobacterial antigens and have thus been the focus of research to develop vaccines…”
Get full text

A regulatory variant in the C1Q gene cluster is associated with tuberculosis susceptibility and C1qA plasma levels in a South African population by Bruiners, Natalie, Schurz, Haiko, Daya, Michelle, Salie, Muneeb, van Helden, Paul D, Kinnear, Craig J, Hoal, Eileen G, Möller, Marlo, Gey van Pittius, Nicolaas C.

“…Several genetic studies have implicated genes that encode for components of the innate immune response in tuberculosis (TB) susceptibility. The complement…”
Get full text

Comparative analysis of Mycobacterium tuberculosis pe and ppe genes reveals high sequence variation and an apparent absence of selective constraints by McEvoy, Christopher R E, Cloete, Ruben, Müller, Borna, Schürch, Anita C, van Helden, Paul D, Gagneux, Sebastien, Warren, Robin M, Gey van Pittius, Nicolaas C

“…Mycobacterium tuberculosis complex (MTBC) genomes contain 2 large gene families termed pe and ppe. The function of pe/ppe proteins remains enigmatic but…”
Get full text