Search Results - "Gewurz, Benjamin E."

Epstein-Barr Virus LMP1-Mediated Oncogenicity by Wang, Liang Wei, Jiang, Sizun, Gewurz, Benjamin E

“…Epstein-Barr virus latent membrane protein 1 (LMP1) is expressed in multiple human malignancies, including nasopharyngeal carcinoma and Hodgkin and…”
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SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication by Zhang, Yuchen, Guo, Rui, Kim, Sharon H., Shah, Hardik, Zhang, Shuting, Liang, Jin Hua, Fang, Ying, Gentili, Matteo, Leary, Colin N. O’, Elledge, Steven J., Hung, Deborah T., Mootha, Vamsi K., Gewurz, Benjamin E.

“…The recently identified Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic. How this novel beta-coronavirus…”
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Epstein-Barr Virus Oncoprotein Super-enhancers Control B Cell Growth by Zhou, Hufeng, Schmidt, Stefanie C.S., Jiang, Sizun, Willox, Bradford, Bernhardt, Katharina, Liang, Jun, Johannsen, Eric C., Kharchenko, Peter, Gewurz, Benjamin E., Kieff, Elliott, Zhao, Bo

“…Super-enhancers are clusters of gene-regulatory sites bound by multiple transcription factors that govern cell transcription, development, phenotype, and…”
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Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation by Wang, Liang Wei, Shen, Hongying, Nobre, Luis, Ersing, Ina, Paulo, Joao A., Trudeau, Stephen, Wang, Zhonghao, Smith, Nicholas A., Ma, Yijie, Reinstadler, Bryn, Nomburg, Jason, Sommermann, Thomas, Cahir-McFarland, Ellen, Gygi, Steven P., Mootha, Vamsi K., Weekes, Michael P., Gewurz, Benjamin E.

“…Epstein-Barr virus (EBV) causes Burkitt, Hodgkin, and post-transplant B cell lymphomas. How EBV remodels metabolic pathways to support rapid B cell outgrowth…”
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Epstein-Barr virus BNRF1 destabilizes SMC5/6 cohesin complexes to evade its restriction of replication compartments by Yiu, Stephanie Pei Tung, Guo, Rui, Zerbe, Cassie, Weekes, Michael P., Gewurz, Benjamin E.

“…Epstein-Barr virus (EBV) persistently infects people worldwide. Delivery of ∼170-kb EBV genomes to nuclei and use of nuclear membrane-less replication…”
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MYC Controls the Epstein-Barr Virus Lytic Switch by Guo, Rui, Jiang, Chang, Zhang, Yuchen, Govande, Apurva, Trudeau, Stephen J., Chen, Fang, Fry, Christopher J., Puri, Rishi, Wolinsky, Emma, Schineller, Molly, Frost, Thomas C., Gebre, Makda, Zhao, Bo, Giulino-Roth, Lisa, Doench, John G., Teng, Mingxiang, Gewurz, Benjamin E.

“…Epstein-Barr virus (EBV) is associated with multiple human malignancies. To evade immune detection, EBV switches between latent and lytic programs. How viral…”
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Epstein-Barr virus subverts mevalonate and fatty acid pathways to promote infected B-cell proliferation and survival by Wang, Liang Wei, Wang, Zhonghao, Ersing, Ina, Nobre, Luis, Guo, Rui, Jiang, Sizun, Trudeau, Stephen, Zhao, Bo, Weekes, Michael P, Gewurz, Benjamin E

“…Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with multiple human malignancies. EBV drives B-cell proliferation, which contributes…”
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Epstein-Barr virus oncoprotein-driven B cell metabolism remodeling by Burton, Eric M, Gewurz, Benjamin E

“…Funding: We acknowledge support by NIH RO1 AI137337, AI164709 and CA228700 and a Burroughs Wellcome Career Award in Medical Sciences to BEG and by NIH…”
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Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade by Gu, Shengqing Stan, Zhang, Wubing, Wang, Xiaoqing, Jiang, Peng, Traugh, Nicole, Li, Ziyi, Meyer, Clifford, Stewig, Blair, Xie, Yingtian, Bu, Xia, Manos, Michael P, Font-Tello, Alba, Gjini, Evisa, Lako, Ana, Lim, Klothilda, Conway, Jake, Tewari, Alok K, Zeng, Zexian, Sahu, Avinash Das, Tokheim, Collin, Weirather, Jason L, Fu, Jingxin, Zhang, Yi, Kroger, Benjamin, Liang, Jin Hua, Cejas, Paloma, Freeman, Gordon J, Rodig, Scott, Long, Henry W, Gewurz, Benjamin E, Hodi, F Stephen, Brown, Myles, Liu, X Shirley

“…Immune checkpoint blockade (ICB) therapy revolutionized cancer treatment, but many patients with impaired MHC-I expression remain refractory. Here, we combined…”
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Germinal center cytokine driven epigenetic control of Epstein-Barr virus latency gene expression by Liao, Yifei, Yan, Jinjie, Beri, Nina R, Giulino-Roth, Lisa, Cesarman, Ethel, Gewurz, Benjamin E

“…Epstein-Barr virus (EBV) persistently infects 95% of adults worldwide and is associated with multiple human lymphomas that express characteristic EBV latency…”
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The NF-κB Genomic Landscape in Lymphoblastoid B Cells by Zhao, Bo, Barrera, Luis A., Ersing, Ina, Willox, Bradford, Schmidt, Stefanie C.S., Greenfeld, Hannah, Zhou, Hufeng, Mollo, Sarah B., Shi, Tommy T., Takasaki, Kaoru, Jiang, Sizun, Cahir-McFarland, Ellen, Kellis, Manolis, Bulyk, Martha L., Kieff, Elliott, Gewurz, Benjamin E.

“…The nuclear factor κB (NF-κΒ) subunits RelA, RelB, cRel, p50, and p52 are each critical for B cell development and function. To systematically characterize…”
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Epigenetic reprogramming sensitizes immunologically silent EBV+ lymphomas to virus-directed immunotherapy by Dalton, Tanner, Doubrovina, Ekaterina, Pankov, Dmitry, Reynolds, Raymond, Scholze, Hanna, Selvakumar, Annamalai, Vizconde, Teresa, Savalia, Bhumesh, Dyomin, Vadim, Weigel, Christoph, Oakes, Christopher C., Alonso, Alicia, Elemento, Olivier, Pan, Heng, Phillip, Jude M., O'Reilly, Richard J., Gewurz, Benjamin E., Cesarman, Ethel, Giulino-Roth, Lisa

“…Despite advances in T-cell immunotherapy against Epstein-Barr virus (EBV)-infected lymphomas that express the full EBV latency III program, a critical barrier…”
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The nucleic acid binding protein SFPQ represses EBV lytic reactivation by promoting histone H1 expression by Murray-Nerger, Laura A., Lozano, Clarisel, Burton, Eric M., Liao, Yifei, Ungerleider, Nathan A., Guo, Rui, Gewurz, Benjamin E.

“…Epstein-Barr virus (EBV) uses a biphasic lifecycle of latency and lytic reactivation to infect >95% of adults worldwide. Despite its central role in EBV…”
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Mouse model of Epstein–Barr virus LMP1- and LMP2A-driven germinal center B-cell lymphoproliferative disease by Minamitani, Takeharu, Ma, Yijie, Zhou, Hufeng, Kida, Hiroshi, Tsai, Chao-Yuan, Obana, Masanori, Okuzaki, Daisuke, Fujio, Yasushi, Kumanogoh, Atsushi, Zhao, Bo, Kikutani, Hitoshi, Kieff, Elliott, Gewurz, Benjamin E., Yasui, Teruhito

“…Epstein–Barr virus (EBV) is a major cause of immunosuppression-related B-cell lymphomas and Hodgkin lymphoma (HL). In these malignancies, EBV latent membrane…”
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Epstein-Barr Virus Induced Cytidine Metabolism Roles in Transformed B-Cell Growth and Survival by Liang, Jin Hua, Wang, Chong, Yiu, Stephanie Pei Tung, Zhao, Bo, Guo, Rui, Gewurz, Benjamin E

“…Epstein-Barr virus (EBV) is associated with 200,000 cancers annually, including B-cell lymphomas in immunosuppressed hosts. Hypomorphic mutations of the…”
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Innate Immune Modulation Induced by EBV Lytic Infection Promotes Endothelial Cell Inflammation and Vascular Injury in Scleroderma by Farina, Antonella, Rosato, Edoardo, York, Michael, Gewurz, Benjamin E, Trojanowska, Maria, Farina, Giuseppina Alessandra

“…Microvascular injury is considered an initial event in the pathogenesis of scleroderma and endothelial cells are suspected of being the target of the…”
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EBNA1 inhibitors have potent and selective antitumor activity in xenograft models of Epstein–Barr virus-associated gastric cancer by Soldan, Samantha S., Anderson, Emma M., Frase, Drew M., Zhang, Yue, Caruso, Lisa B., Wang, Yin, Deakyne, Julianna S., Gewurz, Benjamin E., Tempera, Italo, Lieberman, Paul M., Messick, Troy E.

“…Background and aims Epstein–Barr virus (EBV)-associated gastric carcinoma (EBVaGC) is the most common EBV-associated cancer and accounts for ~ 10% of all…”
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A DNA tumor virus globally reprograms host 3D genome architecture to achieve immortal growth by Wang, Chong, Liu, Xiang, Liang, Jun, Narita, Yohei, Ding, Weiyue, Li, Difei, Zhang, Luyao, Wang, Hongbo, Leong, Merrin Man Long, Hou, Isabella, Gerdt, Catherine, Jiang, Chang, Zhong, Qian, Tang, Zhonghui, Forney, Carmy, Kottyan, Leah, Weirauch, Matthew T., Gewurz, Benjamin E., Zeng, Mu-sheng, Jiang, Sizun, Teng, Mingxiang, Zhao, Bo

“…Epstein-Barr virus (EBV) immortalization of resting B lymphocytes (RBLs) to lymphoblastoid cell lines (LCLs) models human DNA tumor virus oncogenesis. RBL and…”
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The nuclear lamina binds the EBV genome during latency and regulates viral gene expression by Caruso, Lisa Beatrice, Guo, Rui, Keith, Kelsey, Madzo, Jozef, Maestri, Davide, Boyle, Sarah, Wasserman, Jason, Kossenkov, Andrew, Gewurz, Benjamin E, Tempera, Italo

“…The Epstein Barr virus (EBV) infects almost 95% of the population worldwide. While typically asymptomatic, EBV latent infection is associated with several…”
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Epigenetic crossroads of the Epstein-Barr virus B-cell relationship by Frost, Thomas C, Gewurz, Benjamin E

“…[Display omitted] Key epigenetic mechanisms regulating EBV and B-cell gene expression. Upon B-cell infection, the EBV genome rapidly becomes chromatinized to…”
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