Search Results - "Gewirtz, David A"

The Four Faces of Autophagy: Implications for Cancer Therapy by GEWIRTZ, David A

“…It is generally thought that autophagy has two primary and opposing functions in tumor cells in response to stress induced by chemotherapy or radiation. One is…”
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Tumor Cell Escape from Therapy-Induced Senescence as a Model of Disease Recurrence after Dormancy by Saleh, Tareq, Tyutyunyk-Massey, Liliya, Gewirtz, David A

“…Senescence, a durable form of growth arrest, represents a primary response to numerous anticancer therapies. Although the paradigm that senescence is…”
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The Challenge of Developing Autophagy Inhibition as a Therapeutic Strategy by Gewirtz, David A

“…The finding that cancer chemotherapeutic drugs and ionizing radiation often promote autophagy has provided the foundation for clinical trials combining…”
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Triangular Relationship between p53, Autophagy, and Chemotherapy Resistance by Xu, Jingwen, Patel, Nipa H, Gewirtz, David A

“…Chemotherapy and radiation often induce a number of cellular responses, such as apoptosis, autophagy, and senescence. One of the major regulators of these…”
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Is Autophagy Always a Barrier to Cisplatin Therapy? by Xu, Jingwen, Gewirtz, David A

“…Cisplatin has long been a first-line chemotherapeutic agent in the treatment of cancer, largely for solid tumors. During the course of the past two decades,…”
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Cytoprotective and nonprotective autophagy in cancer therapy by Gewirtz, David A.

“…Two primary forms of autophagy have been identified in the field of cancer therapy based on their apparent functions in the tumor cell; these are the…”
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Therapy-Induced Senescence: An "Old" Friend Becomes the Enemy by Saleh, Tareq, Bloukh, Sarah, Carpenter, Valerie J, Alwohoush, Enas, Bakeer, Jomana, Darwish, Sarah, Azab, Belal, Gewirtz, David A

“…For the past two decades, cellular senescence has been recognized as a central component of the tumor cell response to chemotherapy and radiation…”
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Autophagy in malignant transformation and cancer progression by Galluzzi, Lorenzo, Pietrocola, Federico, Bravo-San Pedro, José Manuel, Amaravadi, Ravi K, Baehrecke, Eric H, Cecconi, Francesco, Codogno, Patrice, Debnath, Jayanta, Gewirtz, David A, Karantza, Vassiliki, Kimmelman, Alec, Kumar, Sharad, Levine, Beth, Maiuri, Maria Chiara, Martin, Seamus J, Penninger, Josef, Piacentini, Mauro, Rubinsztein, David C, Simon, Hans-Uwe, Simonsen, Anne, Thorburn, Andrew M, Velasco, Guillermo, Ryan, Kevin M, Kroemer, Guido

“…Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells, such a homeostatic activity constitutes a robust barrier against…”
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Is Senescence Reversible? by Chakradeo, Shweta, Elmore, Lynne W, Gewirtz, David A

“…Senescence was originally identified by the finite lifespan of normal cells that is a consequence of telomere shortening with each cycle of DNA replication…”
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Cytoprotective, Cytotoxic and Cytostatic Roles of Autophagy in Response to BET Inhibitors by Elshazly, Ahmed M, Gewirtz, David A

“…The bromodomain and extra-terminal domain (BET) family inhibitors are small molecules that target the dysregulated epigenetic readers, BRD2, BRD3, BRD4 and…”
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Autophagy, senescence and tumor dormancy in cancer therapy by Gewirtz, David A.

“…The relationships between autophagy and apoptosis have been examined quite extensively and have often been shown to be reciprocally regulated responses to…”
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The Cytoprotective Role of Autophagy in Response to BRAF-Targeted Therapies by Elshazly, Ahmed M, Gewirtz, David A

“…BRAF-targeted therapies are widely used for the treatment of melanoma patients with BRAF V600 mutations. Vemurafenib, dabrafenib as well as encorafenib have…”
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The Switch between Protective and Nonprotective Autophagy; Implications for Autophagy Inhibition as a Therapeutic Strategy in Cancer by Gewirtz, David A

“…Autophagy, a process of cellular self-degradation and cell survival whereby the cell generates energy and metabolic intermediates under conditions of stress…”
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The Roles of Autophagy and Senescence in the Tumor Cell Response to Radiation by Patel, Nipa H., Sohal, Sahib S., Manjili, Masoud H, Harrell, J. Chuck, Gewirtz, David A.

“…Radiation is a critical pillar in cancer therapeutics, exerting its anti-tumor DNA-damaging effects through various direct and indirect mechanisms. Radiation…”
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Cytotoxic autophagy in cancer therapy by Sharma, Khushboo, Le, Ngoc, Alotaibi, Moureq, Gewirtz, David A

“…Autophagy is a process of cellular self-digestion, whereby the cell degrades subcellular materials in order to generate energy and metabolic precursors in…”
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Clearance of therapy‐induced senescent tumor cells by the senolytic ABT‐263 via interference with BCL‐XL–BAX interaction by Saleh, Tareq, Carpenter, Valerie J., Tyutyunyk‐Massey, Liliya, Murray, Graeme, Leverson, Joel D., Souers, Andrew J., Alotaibi, Moureq R., Faber, Anthony C., Reed, Jason, Harada, Hisashi, Gewirtz, David A.

“…Senescent tumor cells can be selectively eliminated by the BH3 mimetic, ABT‐263 (navitoclax), via senolysis. We show that ABT‐263 inhibits the interaction…”
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Effects of paclitaxel on the development of neuropathy and affective behaviors in the mouse by Toma, Wisam, Kyte, S. Lauren, Bagdas, Deniz, Alkhlaif, Yasmin, Alsharari, Shakir D., Lichtman, Aron H., Chen, Zhi-Jian, Del Fabbro, Egidio, Bigbee, John W., Gewirtz, David A., Damaj, M. Imad

“…Paclitaxel, one of the most commonly used cancer chemotherapeutic drugs, effectively extends the progression-free survival of breast, lung, and ovarian cancer…”
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Editorial: Risks and Benefits of Adjuvants to Cancer Therapies by Dong, Peixin, Gewirtz, David A

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Young plasma reverses age‐dependent alterations in hepatic function through the restoration of autophagy by Liu, Anding, Guo, Enshuang, Yang, Jiankun, Yang, Yan, Liu, Shenpei, Jiang, Xiaojing, Hu, Qi, Dirsch, Olaf, Dahmen, Uta, Zhang, Cuntai, Gewirtz, David A, Fang, Haoshu

“…Summary Recent studies showing the therapeutic effect of young blood on aging‐associated deterioration of organs point to young blood as the solution for…”
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Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy by Curry, Zachary A, Wilkerson, Jenny L, Bagdas, Deniz, Kyte, S Lauren, Patel, Nipa, Donvito, Giulia, Mustafa, Mohammed A, Poklis, Justin L, Niphakis, Micah J, Hsu, Ku-Lung, Cravatt, Benjamin F, Gewirtz, David A, Damaj, M Imad, Lichtman, Aron H

“…Although paclitaxel effectively treats various cancers, its debilitating peripheral neuropathic pain side effects often persist long after treatment has ended…”
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