Search Results - "Gewies, Andreas"

Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells by Rosenbaum, Marc, Gewies, Andreas, Pechloff, Konstanze, Heuser, Christoph, Engleitner, Thomas, Gehring, Torben, Hartjes, Lara, Krebs, Sabrina, Krappmann, Daniel, Kriegsmann, Mark, Weichert, Wilko, Rad, Roland, Kurts, Christian, Ruland, Jürgen

“…Regulatory T cells (Tregs) have crucial functions in the inhibition of immune responses. Their development and suppressive functions are controlled by the T…”
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Alternative splicing of MALT1 controls signalling and activation of CD4+ T cells by Meininger, Isabel, Griesbach, Richard A., Hu, Desheng, Gehring, Torben, Seeholzer, Thomas, Bertossi, Arianna, Kranich, Jan, Oeckinghaus, Andrea, Eitelhuber, Andrea C., Greczmiel, Ute, Gewies, Andreas, Schmidt-Supprian, Marc, Ruland, Jürgen, Brocker, Thomas, Heissmeyer, Vigo, Heyd, Florian, Krappmann, Daniel

“…MALT1 channels proximal T-cell receptor (TCR) signalling to downstream signalling pathways. With MALT1A and MALT1B two conserved splice variants exist and we…”
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TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions by O'Neill, Thomas J, Gewies, Andreas, Seeholzer, Thomas, Krappmann, Daniel

“…MALT1 is a core component of the CARD11-BCL10-MALT1 (CBM) signalosome, in which it acts as a scaffold and a protease to bridge T cell receptor (TCR) ligation…”
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Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells by Ferch, Uta, Kloo, Bernhard, Gewies, Andreas, Pfänder, Vera, Düwel, Michael, Peschel, Christian, Krappmann, Daniel, Ruland, Jürgen

“…Diffuse large B cell lymphoma (DLBCL) is the most common type of lymphoma in humans. The aggressive activated B cell-like (ABC) subtype of DLBCL is…”
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Uncoupling Malt1 Threshold Function from Paracaspase Activity Results in Destructive Autoimmune Inflammation by Gewies, Andreas, Gorka, Oliver, Bergmann, Hanna, Pechloff, Konstanze, Petermann, Franziska, Jeltsch, Katharina M., Rudelius, Martina, Kriegsmann, Mark, Weichert, Wilko, Horsch, Marion, Beckers, Johannes, Wurst, Wolfgang, Heikenwalder, Mathias, Korn, Thomas, Heissmeyer, Vigo, Ruland, Jürgen

“…The paracaspase Malt1 is a central regulator of antigen receptor signaling that is frequently mutated in human lymphoma. As a scaffold, it assembles protein…”
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The CARD11-BCL10-MALT1 ( CBM ) signalosome complex: Stepping into the limelight of human primary immunodeficiency by Turvey, Stuart E., MBBS, DPhil, FRCPC, Durandy, Anne, MD, PhD, Fischer, Alain, MD, PhD, Fung, Shan-Yu, PhD, Geha, Raif S., MD, Gewies, Andreas, PhD, Giese, Thomas, MD, Greil, Johann, MD, Keller, Bärbel, MSc, McKinnon, Margaret L., MD, Neven, Bénédicte, MD, Rozmus, Jacob, MD, Ruland, Jürgen, MD, Snow, Andrew L., PhD, Stepensky, Polina, MD, Warnatz, Klaus, MD

“…Next-generation DNA sequencing has accelerated the genetic characterization of many human primary immunodeficiency diseases (PIDs). These discoveries can be…”
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A homozygous mucosa-associated lymphoid tissue 1 ( MALT1 ) mutation in a family with combined immunodeficiency by Jabara, Haifa H., BSc, Ohsumi, Toshiro, PhD, Chou, Janet, MD, Massaad, Michel J., PhD, Benson, Halli, BSc, Megarbane, Andre, MD, PhD, Chouery, Eliane, PhD, Mikhael, Raymond, MD, Gorka, Oliver, MD, Gewies, Andreas, PhD, Portales, Pierre, MD, Nakayama, Toshinori, MD, PhD, Hosokawa, Hiroyuki, PhD, Revy, Patrick, PhD, Herrod, Henry, MD, Le Deist, Francoise, MD, PhD, Lefranc, Gerard, PhD, Ruland, Jürgen, MD, Geha, Raif S., MD

“…Background Combined immunodeficiency (CID) is characterized by severe recurrent infections with normal numbers of T and B lymphocytes but with deficient…”
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Optimized CRISPR-Cas9-based Strategy for Complex Gene Targeting in Murine Embryonic Stem Cells for Germline Transmission by O'Neill, Thomas J, Krappmann, Daniel, Gewies, Andreas

“…Although CRISPR-Cas9 genome editing can be performed directly in single-cell mouse zygotes, the targeting efficiency for more complex modifications such as the…”
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Prdm6 controls heart development by regulating neural crest cell differentiation and migration by Hong, Lingjuan, Li, Na, Gasque, Victor, Mehta, Sameet, Ye, Lupeng, Wu, Yinyu, Li, Jinyu, Gewies, Andreas, Ruland, Jürgen, Hirschi, Karen K, Eichmann, Anne, Hendry, Caroline, van Dijk, David, Mani, Arya

“…The molecular mechanisms that drive the acquisition of distinct neural crest cell (NCC) fates is still poorly understood. Here, we identified Prdm6 as an…”
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Increased Tumoral Microenvironmental pH Improves Cytotoxic Effect of Pharmacologic Ascorbic Acid in Castration-Resistant Prostate Cancer Cells by Li, Zhoulei, He, Peng, Luo, Ganhua, Shi, Xinchong, Yuan, Gang, Zhang, Bing, Seidl, Christof, Gewies, Andreas, Wang, Yue, Zou, Yuan, Long, Yali, Yue, Dianchao, Zhang, Xiangsong

“…The anticancer potential of pharmacologic ascorbic acid (AA) has been detected in a number of cancer cells. However, study suggested a strongly reduced…”
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Loss of Ifnar1 in Pancreatic Acinar Cells Ameliorates the Disease Course of Acute Pancreatitis by Miller, Katharina J, Raulefs, Susanne, Kong, Bo, Steiger, Katja, Regel, Ivonne, Gewies, Andreas, Kleeff, Jörg, Michalski, Christoph W

“…Type I interferon constitutes an essential component of the combinational therapy against viral disease. Acute pancreatitis is one side effect of type I…”
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Prdm6 is essential for cardiovascular development in vivo by Gewies, Andreas, Castineiras-Vilarino, Mercedes, Ferch, Uta, Jährling, Nina, Heinrich, Katja, Hoeckendorf, Ulrike, Przemeck, Gerhard K H, Munding, Matthias, Groß, Olaf, Schroeder, Timm, Horsch, Marion, Karran, E Loraine, Majid, Aneela, Antonowicz, Stefan, Beckers, Johannes, Hrabé de Angelis, Martin, Dodt, Hans-Ulrich, Peschel, Christian, Förster, Irmgard, Dyer, Martin J S, Ruland, Jürgen

“…Members of the PRDM protein family have been shown to play important roles during embryonic development. Previous in vitro and in situ analyses indicated a…”
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Methods to Study CARD11-BCL10-MALT1 Dependent Canonical NF-κB Activation in Jurkat T Cells by Gewies, Andreas, Graß, Carina, Krappmann, Daniel

“…Jurkat T cells have been of central importance for the discovery of signalling mediators driving NF-κB activation in response to T cell antigen receptor…”
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p53 is involved in tumor necrosis factor-α-induced apoptosis in the human prostatic carcinoma cell line LNCaP by ROKHLIN, O. W, GUDKOV, A. V, KWEK, S, GLOVER, R. A, GEWIES, A. S, COHEN, M. B

“…The human prostatic carcinoma cell line LNCaP is sensitive to TNF-alpha treatment and expresses wild-type p53. To analyse the possible role of p53 in…”
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Clec12a Is an Inhibitory Receptor for Uric Acid Crystals that Regulates Inflammation in Response to Cell Death by Neumann, Konstantin, Castiñeiras-Vilariño, Mercedes, Höckendorf, Ulrike, Hannesschläger, Nicole, Lemeer, Simone, Kupka, Danny, Meyermann, Svenia, Lech, Maciej, Anders, Hans-Joachim, Kuster, Bernhard, Busch, Dirk H., Gewies, Andreas, Naumann, Ronald, Groß, Olaf, Ruland, Jürgen

“…Recognition of cell death by the innate immune system triggers inflammatory responses. However, how these reactions are regulated is not well understood. Here,…”
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Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity by Ruland, Jürgen, Gross, Olaf, Gewies, Andreas, Finger, Katrin, Schäfer, Martin, Sparwasser, Tim, Peschel, Christian, Förster, Irmgard

“…Fungal infections are increasing worldwide due to the marked rise in immunodeficiencies including AIDS; however, immune responses to fungi are poorly…”
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Human immune disorder associated with homozygous hypomorphic mutation affecting MALT1B splice variant by Kutukculer, Necil, Seeholzer, Thomas, O’Neill, Thomas J., Graß, Carina, Aykut, Ayca, Karaca, Neslihan Edeer, Durmaz, Asude, Cogulu, Ozgur, Aksu, Guzide, Gehring, Torben, Gewies, Andreas, Krappmann, Daniel

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Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity by Schmidt, Henrik, Raj, Timsse, O'Neill, Thomas J., Muschaweckh, Andreas, Giesert, Florian, Negraschus, Arlinda, Hoefig, Kai P., Behrens, Gesine, Esser, Lena, Baumann, Christina, Feederle, Regina, Plaza-Sirvent, Carlos, Geerlof, Arie, Gewies, Andreas, Isay, Sophie E., Ruland, Jürgen, Schmitz, Ingo, Wurst, Wolfgang, Korn, Thomas, Krappmann, Daniel, Heissmeyer, Vigo

“…Constitutive activation of the MALT1 paracaspase in conventional T cells of Malt1 TBM/TBM (TRAF6 Binding Mutant = TBM) mice causes fatal inflammation and…”
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The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma by Pechloff, Konstanze, Holch, Julian, Ferch, Uta, Schweneker, Marc, Brunner, Kristina, Kremer, Markus, Sparwasser, Tim, Quintanilla-Martinez, Leticia, Zimber-Strobl, Ursula, Streubel, Berthold, Gewies, Andreas, Peschel, Christian, Ruland, Jürgen

“…Peripheral T cell lymphomas (PTCLs) are highly aggressive malignancies with poor prognosis. Their molecular pathogenesis is not well understood and small…”
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TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease by O'Neill, Thomas J, Seeholzer, Thomas, Gewies, Andreas, Gehring, Torben, Giesert, Florian, Hamp, Isabel, Graß, Carina, Schmidt, Henrik, Kriegsmann, Katharina, Tofaute, Marie J, Demski, Katrin, Poth, Tanja, Rosenbaum, Marc, Schnalzger, Theresa, Ruland, Jürgen, Göttlicher, Martin, Kriegsmann, Mark, Naumann, Ronald, Heissmeyer, Vigo, Plettenburg, Oliver, Wurst, Wolfgang, Krappmann, Daniel

“…Balanced control of T cell signaling is critical for adaptive immunity and protection from autoimmunity. By combining genetically engineered mouse models,…”
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