Search Results - "Gewartowska, Olga"
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Immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C
Published in Nature communications (27-04-2020)“…TENT5C is a non-canonical cytoplasmic poly(A) polymerase highly expressed by activated B cells to suppress their proliferation. Here we measure the global…”
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The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma
Published in Nature communications (20-09-2017)“…FAM46C is one of the most frequently mutated genes in multiple myeloma. Here, using a combination of in vitro and in vivo approaches, we demonstrate that…”
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TENT5-mediated polyadenylation of mRNAs encoding secreted proteins is essential for gametogenesis in mice
Published in Nature communications (22-06-2024)“…Cytoplasmic polyadenylation plays a vital role in gametogenesis; however, the participating enzymes and substrates in mammals remain unclear. Using knockout…”
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Home range size, habitat selection and roost use by the whiskered bat (Myotis mystacinus) in human-dominated montane landscapes
Published in PloS one (09-10-2020)“…Our understanding of animal adaptations to human pressure is limited by the focus on rare taxa, despite that common species are more significant in shaping…”
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Cytoplasmic polyadenylation by TENT5A is required for proper bone formation
Published in Cell reports (Cambridge) (20-04-2021)“…Osteoblasts orchestrate bone formation through the secretion of type I collagen and other constituents of the matrix on which hydroxyapatite crystals…”
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Mutation in the mitochondrial chaperone TRAP1 leads to autism with more severe symptoms in males
Published in EMBO molecular medicine (27-09-2024)“…There is increasing evidence of mitochondrial dysfunction in autism spectrum disorders (ASD), but the causal relationships are unclear. In an ASD patient whose…”
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Disrupting interaction between miR-132 and Mmp9 3′UTR improves synaptic plasticity and memory in mice
Published in Frontiers in molecular neuroscience (05-08-2022)“…As microRNAs have emerged to be important regulators of molecular events occurring at the synapses, the new questions about their regulatory effect on the…”
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8
The role of cytoplasmic mRNA polyadenylation in the pathogenesis of Osteogenesis imperfecta
Published in Bone Reports (01-10-2020)Get full text
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Terminal nucleotidyl transferases (TENTs) in mammalian RNA metabolism
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (05-11-2018)“…In eukaryotes, almost all RNA species are processed at their 3′ ends and most mRNAs are polyadenylated in the nucleus by canonical poly(A) polymerases. In…”
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Zygotic activin A is dispensable for the mouse preimplantation embryo development and for the derivation and pluripotency of embryonic stem cells
Published in Biology of reproduction (06-11-2024)“…In this work, we aimed to determine the role of activin A during crucial events of mouse embryogenesis and distinguish the function of the protein of zygotic…”
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11
Terminal nucleotidyl transferases (TENTs) in mammalian RNA metabolism
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (19-12-2018)“…In eukaryotes, almost all RNA species are processed at their 3ʹ ends and most mRNAs are polyadenylated in the nucleus by canonical poly(A) polymerases. In…”
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12
Home range size, habitat selection and roost use by the whiskered bat
Published in PloS one (09-10-2020)“…Our understanding of animal adaptations to human pressure is limited by the focus on rare taxa, despite that common species are more significant in shaping…”
Get full text
Journal Article -
13
Disrupting interaction between miR-132 and Mmp9 3'UTR improves synaptic plasticity and memory in mice
Published in Frontiers in molecular neuroscience (01-01-2022)“…As microRNAs have emerged to be important regulators of molecular events occurring at the synapses, the new questions about their regulatory effect on the…”
Get full text
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