Search Results - "Geurts, J. J. G."

Will the real multiple sclerosis please stand up? by Stys, Peter K., Zamponi, Gerald W., van Minnen, Jan, Geurts, Jeroen J. G.

“…Multiple sclerosis (MS) is generally considered to be an autoimmune, inflammatory disease. In this provocative Perspective, Stys and colleagues propose that…”
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Complement C1q-C3-associated synaptic changes in multiple sclerosis hippocampus by Michailidou, Iliana, Willems, Janske G. P., Kooi, Evert-Jan, van Eden, Corbert, Gold, Stefan M., Geurts, Jeroen J. G., Baas, Frank, Huitinga, Inge, Ramaglia, Valeria

“…Objective Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, leading to memory impairment in up to 65% of patients. Memory…”
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Regulation of microglial TMEM119 and P2RY12 immunoreactivity in multiple sclerosis white and grey matter lesions is dependent on their inflammatory environment by van Wageningen, Thecla A, Vlaar, Eva, Kooij, Gijs, Jongenelen, Cornelis A M, Geurts, Jeroen J G, van Dam, Anne-Marie

“…Multiple Sclerosis (MS) is the most common cause of acquired neurological disability in young adults, pathologically characterized by leukocyte infiltration of…”
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Grey matter pathology in multiple sclerosis by Geurts, Jeroen JG, PhD, Barkhof, Frederik, MD

“…Summary Multiple sclerosis (MS) has been classically regarded as a white matter disease. However, recent histopathological studies have convincingly shown that…”
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Relevance of spinal cord abnormalities to clinical disability in multiple sclerosis: MR imaging findings in a large cohort of patients by Lukas, Carsten, Sombekke, Madeleine H, Bellenberg, Barbara, Hahn, Horst K, Popescu, Veronica, Bendfeldt, Kerstin, Radue, Ernst W, Gass, Achim, Borgwardt, Stefan J, Kappos, Ludwig, Naegelin, Yvonne, Knol, Dirk L, Polman, Chris H, Geurts, Jeroen J G, Barkhof, Frederik, Vrenken, Hugo

“…To determine whether spinal cord atrophy differs among disease subtypes in multiple sclerosis (MS) and whether it offers diagnostic and clinical correlative…”
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Measurement and clinical effect of grey matter pathology in multiple sclerosis by Geurts, Jeroen JG, Prof, Calabrese, Massimiliano, MD, Fisher, Elizabeth, PhD, Rudick, Richard A, Prof

“…Summary During the past 10 years, the intense involvement of the grey matter of the CNS in the pathology of multiple sclerosis has become evident. On gross…”
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Non-invasively measured brain activity and radiological progression in diffuse glioma by Numan, T., Kulik, S. D., Moraal, B., Reijneveld, J. C., Stam, C. J., de Witt Hamer, P. C., Derks, J., Bruynzeel, A. M. E., van Linde, M. E., Wesseling, P., Kouwenhoven, M. C. M., Klein, M., Würdinger, T., Barkhof, F., Geurts, J. J. G., Hillebrand, A., Douw, L.

“…Non-invasively measured brain activity is related to progression-free survival in glioma patients, suggesting its potential as a marker of glioma progression…”
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Resting state networks change in clinically isolated syndrome by Roosendaal, Stefan D., Schoonheim, Menno M., Hulst, Hanneke E., Sanz-Arigita, Ernesto J., Smith, Stephen M., Geurts, Jeroen J. G., Barkhof, Frederik

“…Task-functional magnetic resonance imaging studies have shown that early cortical recruitment exists in multiple sclerosis, which can partly explain the…”
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Unraveling the relationship between regional gray matter atrophy and pathology in connected white matter tracts in long-standing multiple sclerosis by Steenwijk, Martijn D., Daams, Marita, Pouwels, Petra J.W., J. Balk, Lisanne, Tewarie, Prejaas K., Geurts, Jeroen J. G., Barkhof, Frederik, Vrenken, Hugo

“…Introduction Gray matter (GM) atrophy is common in multiple sclerosis (MS), but the relationship with white matter (WM) pathology is largely unknown. Some…”
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Improved in vivo detection of cortical lesions in multiple sclerosis using double inversion recovery MR imaging at 3 Tesla by Simon, Birgit, Schmidt, Stephan, Lukas, Carsten, Gieseke, Jürgen, Träber, Frank, Knol, Dirk L., Willinek, Winfried A., Geurts, Jeroen J. G., Schild, Hans H., Barkhof, Frederik, Wattjes, Mike P.

“…Objective To investigate the impact of a higher magnetic field strength of 3 Tesla (T) on the detection rate of cortical lesions in multiple sclerosis (MS)…”
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Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation by van Horssen, Jack, Singh, Shailender, van der Pol, Susanne, Kipp, Markus, Lim, Jamie L, Peferoen, Laura, Gerritsen, Wouter, Kooi, Evert-Jan, Witte, Maarten E, Geurts, Jeroen J G, de Vries, Helga E, Peferoen-Baert, Regina, van den Elsen, Peter J, van der Valk, Paul, Amor, Sandra

“…In brain tissues from multiple sclerosis (MS) patients, clusters of activated HLA-DR-expressing microglia, also referred to as preactive lesions, are located…”
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Assessment of lesions on magnetic resonance imaging in multiple sclerosis: practical guidelines by Filippi, Massimo, Preziosa, Paolo, Banwell, Brenda L, Barkhof, Frederik, Ciccarelli, Olga, De Stefano, Nicola, Geurts, Jeroen J G, Paul, Friedemann, Reich, Daniel S, Toosy, Ahmed T, Traboulsee, Anthony, Wattjes, Mike P, Yousry, Tarek A, Gass, Achim, Lubetzki, Catherine, Weinshenker, Brian G, Rocca, Maria A

“…MRI has improved the diagnostic work-up of multiple sclerosis, but inappropriate image interpretation and application of MRI diagnostic criteria contribute to…”
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Association between pathological and MRI findings in multiple sclerosis by Filippi, Massimo, Brück, Wolfgang, Chard, Declan, Fazekas, Franz, Geurts, Jeroen J G, Enzinger, Christian, Hametner, Simon, Kuhlmann, Tanja, Preziosa, Paolo, Rovira, Àlex, Schmierer, Klaus, Stadelmann, Christine, Rocca, Maria A

“…Pathological evaluation is the gold standard for identifying processes related to multiple sclerosis that explain disease manifestations, and for guiding the…”
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Improved differentiation between MS and vascular brain lesions using FLAIR at 7 Tesla by Kilsdonk, Iris D., Wattjes, Mike P., Lopez-Soriano, Alexandra, Kuijer, Joost P. A., de Jong, Marcus C., de Graaf, Wolter L., Conijn, Mandy M. A., Polman, Chris H., Luijten, Peter R., Geurts, Jeroen J. G., Geerlings, Mirjam I., Barkhof, Frederik

“…Objectives To investigate whether a new magnetic resonance image (MRI) technique called T2*-weighted fluid attenuation inversion recovery (FLAIR*) can…”
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Enhanced number and activity of mitochondria in multiple sclerosis lesions by Witte, Maarten E, Bø, Lars, Rodenburg, Richard J, Belien, Jeroen A, Musters, Rene, Hazes, Thierry, Wintjes, Liesbeth T, Smeitink, Jan A, Geurts, Jeroen JG, De Vries, Helga E, van der Valk, Paul, van Horssen, Jack

“…Mitochondrial dysfunction has been implicated in the development and progression of multiple sclerosis (MS) lesions. Mitochondrial alterations might occur as a…”
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Association between pathological and MRI findings in multiple sclerosis by Filippi, Massimo, Prof, Rocca, Maria A, MD, Barkhof, Frederik, Prof, Brück, Wolfgang, Prof, Chen, Jacqueline T, PhD, Comi, Giancarlo, MD, DeLuca, Gabriele, MD, De Stefano, Nicola, MD, Erickson, Bradley J, PhD, Evangelou, Nikos, Prof, Fazekas, Franz, Prof, Geurts, Jeroen JG, Prof, Lucchinetti, Claudia, Prof, Miller, David H, Prof, Pelletier, Daniel, Prof, Popescu, Bogdan F Gh, PhD, Lassmann, Hans, Prof

“…Summary The identification of pathological processes that could be targeted by therapeutic interventions is a major goal of research into multiple sclerosis…”
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Cortical atrophy patterns in multiple sclerosis are non-random and clinically relevant by Steenwijk, Martijn D, Geurts, Jeroen J G, Daams, Marita, Tijms, Betty M, Wink, Alle Meije, Balk, Lisanne J, Tewarie, Prejaas K, Uitdehaag, Bernard M J, Barkhof, Frederik, Vrenken, Hugo, Pouwels, Petra J W

“…Grey matter atrophy is common in multiple sclerosis. However, in contrast with other neurodegenerative diseases, it is unclear whether grey matter atrophy in…”
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Altered expression patterns of group I and II metabotropic glutamate receptors in multiple sclerosis by Geurts, J. J. G., Wolswijk, G., Bö, L., van der Valk, P., Polman, C. H., Troost, D., Aronica, E.

“…Recent evidence supports a role for glutamate receptors in the pathophysiology of multiple sclerosis. In the present study, we have focused specifically on the…”
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Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations by Gouw, Alida A, Seewann, Alexandra, van der Flier, Wiesje M, Barkhof, Frederik, Rozemuller, Annemieke M, Scheltens, Philip, Geurts, Jeroen J G

“…BackgroundWhite matter hyperintensities (WMH), lacunes and microbleeds are regarded as typical MRI expressions of cerebral small vessel disease (SVD) and they…”
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Disruption of structural and functional networks in long-standing multiple sclerosis by Tewarie, Prejaas, Steenwijk, Martijn D., Tijms, Betty M., Daams, Marita, Balk, Lisanne J., Stam, Cornelis J., Uitdehaag, Bernard M.J., Polman, Chris H., Geurts, Jeroen J.G., Barkhof, Frederik, Pouwels, Petra J.W., Vrenken, Hugo, Hillebrand, Arjan

“…Both gray matter atrophy and disruption of functional networks are important predictors for physical disability and cognitive impairment in multiple sclerosis…”
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