Search Results - "Getzoff, E"

The structural biochemistry of the superoxide dismutases by Perry, J.J.P., Shin, D.S., Getzoff, E.D., Tainer, J.A.

“…The discovery of superoxide dismutases (SODs), which convert superoxide radicals to molecular oxygen and hydrogen peroxide, has been termed the most important…”
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Interaction and influence of child and family characteristics upon success of weight management treatment by Bernstein, Ruth, Getzoff, E., Gelfand, K., Demeule-Hayes, M., Scheimann, A.

“…Purpose Interventions to address childhood obesity demonstrate moderate effects at best. Previous research has focused on factors of the intervention that…”
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Structure of Nitric Oxide Synthase Oxygenase Dimer with Pterin and Substrate by Crane, Brian R., Arvai, Andrew S., Ghosh, Dipak K., Wu, Chaoqun, Getzoff, Elizabeth D., Stuehr, Dennis J., Tainer, John A.

“…Crystal structures of the murine cytokine-inducible nitric oxide synthase oxygenase dimer with active-center water molecules, the substrate L-arginine (L-Arg),…”
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Dietary Intake Quality Improvements after Participation in a Multi-Disciplinary Pediatric Weight Management Program by Demeule-Hayes, M, Hogan, K, Winters, M, Getzoff, E, Parrish, J, Rogers, V, Scheimann, A

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Structure at 0.85 Å resolution of an early protein photocycle intermediate by Getzoff, Elizabeth D, Genick, Ulrich K, Soltis, S. Michael, Kuhn, Peter, Canestrelli, Ilona L

“…Protein photosensors from all kingdoms of life, use bound organic molecules, known as chromophores, to detect light. A specific double bond within each…”
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The Structure of Nitric Oxide Synthase Oxygenase Domain and Inhibitor Complexes by Crane, Brian R., Arvai, Andrew S., Gachhui, Ratan, Wu, Chaoqun, Ghosh, Dipak K., Getzoff, Elizabeth D., Stuehr, Dennis J., Tainer, John A.

“…The nitric oxide synthase oxygenase domain (NOS$_{ox}$) oxidizes arginine to synthesize the cellular signal and defensive cytotoxin nitric oxide (NO). Crystal…”
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Structure of a Protein Photocycle Intermediate by Millisecond Time-Resolved Crystallography by Genick, Ulrich K., Gloria E. O. Borgstahl, Ng, Kingman, Ren, Zhong, Pradervand, Claude, Burke, Patrick M., Šrajer, Vukica, Teng, Tsu-Yi, Schildkamp, Wilfried, McRee, Duncan E., Moffat, Keith, Getzoff, Elizabeth D.

“…The blue-light photoreceptor photoactive yellow protein (PYP) undergoes a self-contained light cycle. The atomic structure of the bleached signaling…”
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Amyotrophic Lateral Sclerosis and Structural Defects in Cu,Zn Superoxide Dismutase by Deng, Han-Xiang, Hentati, Afif, Tainer, John A., Iqbal, Zafar, Cayabyab, Annarueber, Hung, Wu-Yen, Getzoff, Elizabeth D., Hu, Ping, Herzfeldt, Brian, Roos, Raymond P., Warner, Carolyn, Deng, Gang, Soriano, Edwin, Smyth, Celestine, Parge, Hans E., Ahmed, Aftab, Roses, Allen D., Hallewell, Robert A., Pericak-Vance, Margaret A., Siddique, Teepu

“…Single-site mutants in the Cu,Zn superoxide dismutase (SOD) gene (SOD1) occur in patients with the fatal neurodegenerative disorder familial amyotrophic…”
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Site-Specific Mutations Provide New Insights into the Origin of pH Effects and Alternative Spectral Forms in the Photoactive Yellow Protein from Halorhodospira halophila by Meyer, T. E, Devanathan, S, Woo, T, Getzoff, E. D, Tollin, G, Cusanovich, M. A

“…Acid/base titrations of wild-type PYP and mutants, either in buffer or in the presence of chaotropes such as thiocyanate, establish the presence of four…”
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Friendships and social interactions of school-aged children with migraine by Vannatta, K, Getzoff, E A, Gilman, D K, Noll, R B, Gerhardt, C A, Powers, S W, Hershey, A D

“…We set out to evaluate the friendships and social behaviour of school-aged children with migraine. Concern exists regarding the impact of paediatric migraine…”
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Structure of the fibre-forming protein pilin at 2.6 Å resolution by Parge, Hans E, Forest, Katrina T, Hickey, Michael J, Christensen, Deborah A, Getzoff, Elizabeth D, Tainer, John A

“…The crystallographic structure of Neisseria gonorrhoeae pilin, which assembles into the multifunctional pilus adhesion and virulence factor, reveals an…”
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Sulfite reductase structure at 1.6 Å : evolution and catalysis for reduction of inorganic anions by CRANE, B. R, SIEGEL, L. M, GETZOFF, E. D

“…Fundamental chemical transformations for biogeochemical cycling of sulfur and nitrogen are catalyzed by sulfite and nitrite reductases. The crystallographic…”
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Coupling of Hydrogen Bonding to Chromophore Conformation and Function in Photoactive Yellow Protein by Brudler, Ronald, Meyer, Terrence E, Genick, Ulrich K, Devanathan, Savitha, Woo, Tammy T, Millar, David P, Gerwert, Klaus, Cusanovich, Michael A, Tollin, Gordon, Getzoff, Elizabeth D

“…To understand in atomic detail how a chromophore and a protein interact to sense light and send a biological signal, we are characterizing photoactive yellow…”
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Three-dimensional model of coagulation factor Va bound to activated protein C by Pellequer, J L, Gale, A J, Getzoff, E D, Griffin, J H

“…A complete molecular model of blood coagulation factor Va (FVa) bound to anticoagulant activated protein C (APC) and to a phospholipid membrane was…”
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Biological sensors: More than one way to sense oxygen by Pellequer, J-L., Brudler, R., Getzoff, E.D.

“…Recently determined structures of the oxygen-sensing heme domain of the bacterial protein FixL have revealed a new binding environment and signal transduction…”
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Identification of a novel integrin binding site in fibronectin. Differential utilization by beta 3 integrins by Bowditch, R D, Hariharan, M, Tominna, E F, Smith, J W, Yamada, K M, Getzoff, E D, Ginsberg, M H

“…Fibronectin (Fn) binding to the integrins alpha IIb beta 3 and alpha v beta 3 involves the Arg-Gly-Asp sequence. The identification of other regions of Fn that…”
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Photoactive Yellow Protein: A Structural Prototype for the Three-Dimensional Fold of the PAS Domain Superfamily by Pellequer, Jean-Luc, Wager-Smith, Karen A., Kay, Steve A., Getzoff, Elizabeth D.

“…PAS domains are found in diverse proteins throughout all three kingdoms of life, where they apparently function in sensing and signal transduction. Although a…”
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Structures of Tetrahydrobiopterin Binding-Site Mutants of Inducible Nitric Oxide Synthase Oxygenase Dimer and Implicated Roles of Trp457 by Aoyagi, Mika, Arvai, Andrew S, Ghosh, Sanjay, Stuehr, Dennis J, Tainer, John A, Getzoff, Elizabeth D

“…To better understand potential roles of conserved Trp457 of the murine inducible nitric oxide synthase oxygenase domain (iNOSox; residues 1−498) in maintaining…”
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Insights into Lou Gehrig's Disease from the Structure and Instability of the A4V Mutant of Human Cu,Zn Superoxide Dismutase by Cardoso, Rosa M.F., Thayer, Maria M., DiDonato, Michael, Lo, Terence P., Bruns, Cami K., Getzoff, Elizabeth D., Tainer, John A.

“…Mutations in human superoxide dismutase (HSOD) have been linked to the familial form of amyotrophic lateral sclerosis (FALS). Amyotrophic lateral sclerosis…”
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Subunit-Destabilizing Mutations in Drosophila Copper/Zinc Superoxide Dismutase: Neuropathology and a Model of Dimer Dysequilibrium by Phillips, John P., Tainer, John A., Getzoff, Elizabeth D., Boulianne, Gabrielle L., Kirby, Kim, Hilliker, Arthur J.

“…Mutations in Cu/Zn superoxide dismutase (SOD), a hallmark of familial amyotrophic lateral sclerosis (FALS) in humans, are shown here to confer striking…”
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