Search Results - "Getz, Jennifer A"

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys by Kariolis, Mihalis S, Wells, Robert C, Getz, Jennifer A, Kwan, Wanda, Mahon, Cathal S, Tong, Raymond, Kim, Do Jin, Srivastava, Ankita, Bedard, Catherine, Henne, Kirk R, Giese, Tina, Assimon, Victoria A, Chen, Xiaocheng, Zhang, Yin, Solanoy, Hilda, Jenkins, Katherine, Sanchez, Pascal E, Kane, Lesley, Miyamoto, Takashi, Chew, Kylie S, Pizzo, Michelle E, Liang, Nicholas, Calvert, Meredith E K, DeVos, Sarah L, Baskaran, Sulochanadevi, Hall, Sejal, Sweeney, Zachary K, Thorne, Robert G, Watts, Ryan J, Dennis, Mark S, Silverman, Adam P, Zuchero, Y Joy Yu

“…Effective delivery of protein therapeutics to the central nervous system (CNS) has been greatly restricted by the blood-brain barrier (BBB). We describe the…”
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Site-specific targeting of antibody activity in vivo mediated by disease-associated proteases by Erster, Oran, Thomas, Jerry M., Hamzah, Juliana, Jabaiah, Abeer M., Getz, Jennifer A., Schoep, Tobias D., Hall, Sejal S., Ruoslahti, Erkki, Daugherty, Patrick S.

“…As a general strategy to selectively target antibody activity in vivo, a molecular architecture was designed to render binding activity dependent upon…”
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A novel quantitative kinase assay using bacterial surface display and flow cytometry by Henriques, Sónia Troeira, Thorstholm, Louise, Huang, Yen-Hua, Getz, Jennifer A, Daugherty, Patrick S, Craik, David J

“…The inhibition of tyrosine kinases is a successful approach for the treatment of cancers and the discovery of kinase inhibitor drugs is the focus of numerous…”
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A novel biomarker assay qualification strategy for rare human matrices - a case study of biomarkers in aqueous humor by Getz, Jennifer A, Nguy, Trung, Dere, Randall, Maia, Mauricio

“…Measuring pharmacodynamic biomarkers near the therapeutic site of action presents considerable challenges for sites with limited matrix volume or difficult…”
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Neutropenia in Cynomolgus Monkeys With Anti-Drug Antibodies Associated With Administration of Afucosylated Humanized Monoclonal Antibodies by Adedeji, Adeyemi O., Zhong, Fiona, Getz, Jennifer A., Zhong, Zoe, Halpern, Wendy

“…Removal of the core fucose from the Fc region of humanized monoclonal antibodies (afucosylated antibodies) enhances their antibody-dependent cell cytotoxicity…”
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Design of a Cyclotide Antagonist of Neuropilin‑1 and -2 That Potently Inhibits Endothelial Cell Migration by Getz, Jennifer A, Cheneval, Olivier, Craik, David J, Daugherty, Patrick S

“…Neuropilin-1 and -2 are critical regulators of angiogenesis, lymphangiogenesis, and cell survival as receptors for multiple growth factors. Disulfide-rich…”
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Nonclinical pharmacokinetics, pharmacodynamics and safety assessment of a FLT3L-Fc molecule for cancer immunotherapy by Wu, Kai Connie, Adedeji, Adeyemi O., Zabka, Tanja S., Hosseini, Iraj, Kenkre, Radhika, Getz, Jennifer A., Nguyen, Tien, Decalf, Jérémie, Bainbridge, Travis W., Chilton, Jennifer A., Moussion, Christine C., Rao, Gautham K.

“…FLT3L-Fc is a cytokine-Fc fusion agonizing receptor-type tyrosine-protein kinase FLT3 (fms-related tyrosine kinase 3; CD135). FLT3 is expressed on dendritic…”
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Protease-Resistant Peptide Ligands from a Knottin Scaffold Library by Getz, Jennifer A, Rice, Jeffrey J, Daugherty, Patrick S

“…Peptides within the knottin family have been shown to possess inherent stability, making them attractive scaffolds for the development of therapeutic and…”
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Peptide discovery using bacterial display and flow cytometry by Getz, Jennifer A, Schoep, Tobias D, Daugherty, Patrick S

“…Peptides are increasingly used as therapeutic and diagnostic agents. The combination of bacterial cell-surface display peptide libraries with magnetic- and…”
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Identification of protease exosite-interacting peptides that enhance substrate cleavage kinetics by Jabaiah, Abeer M, Getz, Jennifer A, Witkowski, Witold A, Hardy, Jeanne A, Daugherty, Patrick S

“…Many peptidases are thought to require non-active site interaction surfaces, or exosites, to recognize and cleave physiological substrates with high…”
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Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice by Ullman, Julie C, Arguello, Annie, Getz, Jennifer A, Bhalla, Akhil, Mahon, Cathal S, Wang, Junhua, Giese, Tina, Bedard, Catherine, Kim, Do Jin, Blumenfeld, Jessica R, Liang, Nicholas, Ravi, Ritesh, Nugent, Alicia A, Davis, Sonnet S, Ha, Connie, Duque, Joseph, Tran, Hai L, Wells, Robert C, Lianoglou, Steve, Daryani, Vinay M, Kwan, Wanda, Solanoy, Hilda, Nguyen, Hoang, Earr, Timothy, Dugas, Jason C, Tuck, Michael D, Harvey, Jennifer L, Reyzer, Michelle L, Caprioli, Richard M, Hall, Sejal, Poda, Suresh, Sanchez, Pascal E, Dennis, Mark S, Gunasekaran, Kannan, Srivastava, Ankita, Sandmann, Thomas, Henne, Kirk R, Thorne, Robert G, Di Paolo, Gilbert, Astarita, Giuseppe, Diaz, Dolores, Silverman, Adam P, Watts, Ryan J, Sweeney, Zachary K, Kariolis, Mihalis S, Henry, Anastasia G

“…Most lysosomal storage diseases (LSDs) involve progressive central nervous system (CNS) impairment, resulting from deficiency of a lysosomal enzyme. Treatment…”
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Improved brain uptake and efficacy of iduronate 2-sulfatase with the enzyme transport vehicle by Henry, Anastasia G., Kariolis, Mihalis S., Ullman, Julie C., Getz, Jennifer A., Arguello, Annie, Mahon, Cathal, Wang, Junhua, Bhalla, Akhil, Giese, Tina, Bedard, Catherine, Kim, Do Jin, Blumenfeld, Jessica, Liang, Nicholas, Duque, Joseph, Tran, Hai, Wells, Robert C., Astarita, Giuseppe, Dennis, Mark S., Gunasekaran, Kannan, Srivastava, Ankita, Henne, Kirk R., Diaz, Dolo, Silverman, Adam P., Watts, Ryan J., Sweeney, Zachary K.

“…Most lysosomal storage diseases (LSDs) involve progressive central nervous system (CNS) impairment resulting from deficiency in one or more lysosomal enzymes…”
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A Novel Quantitative Kinase Assay Using Bacterial Surface Display and Flow Cytometry: e80474 by Henriques, Sonia Troeira, Thorstholm, Louise, Huang, Yen-Hua, Getz, Jennifer A, Daugherty, Patrick S, Craik, David J

“…The inhibition of tyrosine kinases is a successful approach for the treatment of cancers and the discovery of kinase inhibitor drugs is the focus of numerous…”
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High-Affinity, Stable Peptide Ligands Engineered from a Kalata B1 Knottin Library by Getz, Jennifer A

“…The widespread adoption of peptide therapeutics has been restricted by their poor stability and therefore their limited in vivo half-life and oral…”
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