Search Results - "Gettings, Kelly F."

Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury by Khan, Samina Yasmin, Kelher, Marguerite R., Heal, Joanna M., Blumberg, Neil, Boshkov, Lynn K., Phipps, Richard, Gettings, Kelly F., McLaughlin, Nathan J., Silliman, Christopher C.

“…Transfusion-related acute lung injury (TRALI) is a form of posttransfusion acute pulmonary insufficiency that has been linked to the infusion of biologic…”
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An association between decreased cardiopulmonary complications (transfusion-related acute lung injury and transfusion-associated circulatory overload) and implementation of universal leukoreduction of blood transfusions by Blumberg, Neil, Heal, Joanna M., Gettings, Kelly F., Phipps, Richard P., Masel, Debra, Refaai, Majed A., Kirkley, Scott A., Fialkow, L. Benjamin

“…BACKGROUND: Cardiopulmonary adverse events after transfusion include transfusion‐related acute lung injury (TRALI) and transfusion‐associated circulatory…”
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An association of soluble CD40 ligand (CD154) with adverse reactions to platelet transfusions by Blumberg, Neil, Gettings, Kelly F., Turner, Chantal, Heal, Joanna M., Phipps, Richard P.

“…BACKGROUND: Removal of stored supernatant abrogates most transfusion reactions to leukoreduced platelets (PLTs), suggesting that PLT‐derived soluble mediators…”
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Human bone marrow megakaryocytes and platelets express PPARγ, and PPARγ agonists blunt platelet release of CD40 ligand and thromboxanes by Akbiyik, Filiz, Ray, Denise M., Gettings, Kelly F., Blumberg, Neil, Francis, Charles W., Phipps, Richard P.

“…Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor important in lipid metabolism, diabetes, and inflammation. We…”
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WBC reduction of RBC transfusions is associated with a decreased incidence of RBC alloimmunization by Blumberg, Neil, Heal, Joanna M., Gettings, Kelly F.

“…BACKGROUND: Allogeneic transfusion stimulates Th2 (humoral) immunity. A hypothesis was developed that WBC reduction, by reducing the Th2 stimulus associated…”
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Decreased sepsis related to indwelling venous access devices coincident with implementation of universal leukoreduction of blood transfusions by Blumberg, Neil, Fine, Lynn, Gettings, Kelly F., Heal, Joanna M.

“…BACKGROUND: Randomized trials and animal models demonstrate that leukoreduction of transfusions can reduce the risk of post‐operative infections. We performed…”
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Developmental Changes in Soluble CD40 Ligand by Cholette, Jill M., MD, Blumberg, Neil, MD, Phipps, Richard P., PhD, McDermott, Michael P., PhD, Gettings, Kelly F, Lerner, Norma B., MD, MPH

“…Objectives To determine if soluble CD40 ligand (sCD40L; formally CD154) levels vary with age and to identify age-dependent ranges in healthy pediatric and…”
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ABO Mismatched Platelet, Plasma and Cryoprecipitate Transfusions and Bleeding in Transfused Surgical Patients by Blumberg, Neil, Gettings, Kelly F., Heal, Joanna M.

“…Three observations led us to investigate whether infusion of ABO non-identical platelets might impair, rather than improve hemostasis. (1) Exposure of…”
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Developmental Changes in Soluble CD40 Ligand by Cholette, Jill M., Blumberg, Neil, Phipps, Richard P., McDermott, Michael P., Gettings, Kelly F., Lerner, Norma B.

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TRANSFUSION PRACTICES: Decreased sepsis related to indwelling venous access devices coincident with implementation of universal leukoreduction of blood transfusions by Blumberg, Neil, Fine, Lynn, Gettings, Kelly F, Heal, Joanna M

“…BACKGROUND:Randomized trials and animal models demonstrate that leukoreduction of transfusions can reduce the risk of post-operative infections. We performed a…”
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TRANSFUSION COMPLICATIONS: An association of soluble CD40 ligand (CD154) with adverse reactions to platelet transfusions by Blumberg, Neil, Gettings, Kelly F, Turner, Chantal, Heal, Joanna M, Phipps, Richard P

“…BACKGROUND:Removal of stored supernatant abrogates most transfusion reactions to leukoreduced platelets (PLTs), suggesting that PLT-derived soluble mediators…”
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Human bone marrow megakaryocytes and platelets express PPARgamma, and PPARgamma agonists blunt platelet release of CD40 ligand and thromboxanes by Akbiyik, Filiz, Ray, Denise M, Gettings, Kelly F, Blumberg, Neil, Francis, Charles W, Phipps, Richard P

“…Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand-activated transcription factor important in lipid metabolism, diabetes, and…”
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CD40 Ligand (CD154) as a Cofactor in the Development of Transfusion Related Acute Lung Injury (TRALI) by Blumberg, Neil, Boshkov, Lynn K., Silliman, Christopher C., Kelher, Marguerite, Gettings, Kelly F., Heal, Joanna M., Phipps, Richard P.

“…TRALI is post-transfusion acute pulmonary dysfunction with non-cardiogenic pulmonary edema and profound hypoxia. A number of biologic response mediators(BRMs)…”
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