Search Results - "Getachew, Bruk"

Vitamin D and COVID‐19: Role of ACE2, age, gender, and ethnicity by Getachew, Bruk, Tizabi, Yousef

“…Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) virus, disproportionally targets older people,…”
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Nicotine and the nicotinic cholinergic system in COVID‐19 by Tizabi, Yousef, Getachew, Bruk, Copeland, Robert L., Aschner, Michael

“…There is an urgent need to address the devastating pandemic, COVID‐19, caused by SARS‐CoV‐2. The efforts to understand the details of this disease in hope of…”
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Ketamine interactions with gut-microbiota in rats: relevance to its antidepressant and anti-inflammatory properties by Getachew, Bruk, Aubee, Joseph I, Schottenfeld, Richard S, Csoka, Antonei B, Thompson, Karl M, Tizabi, Yousef

“…Appreciable evidence suggest that dysbiosis in microbiota, reflected in gut microbial imbalance plays a key role in the pathogenesis of neuropsychiatric…”
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COVID-19-associated Coagulopathy: Role of Vitamins D and K by Getachew, Bruk, Landis, Harold E, Manaye, Kebreten F, Tizabi, Yousef

“…Recent reports show coagulopathy as a potential complication and poorer outcome of coronavirus disease 2019 (COVID-19), especially in those with comorbid…”
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Interaction of Heavy Metal Lead with Gut Microbiota: Implications for Autism Spectrum Disorder by Tizabi, Yousef, Bennani, Samia, El Kouhen, Nacer, Getachew, Bruk, Aschner, Michael

“…Autism Spectrum Disorder (ASD), a neurodevelopmental disorder characterized by persistent deficits in social interaction and communication, manifests in early…”
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Heavy Metal Interactions with Neuroglia and Gut Microbiota: Implications for Huntington's Disease by Tizabi, Yousef, Bennani, Samia, El Kouhen, Nacer, Getachew, Bruk, Aschner, Michael

“…Huntington's disease (HD) is a rare but progressive and devastating neurodegenerative disease characterized by involuntary movements, cognitive decline,…”
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Roles of Epigenetics and Glial Cells in Drug-Induced Autism Spectrum Disorder by Csoka, Antonei B, El Kouhen, Nacer, Bennani, Samia, Getachew, Bruk, Aschner, Michael, Tizabi, Yousef

“…Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by severe deficits in social communication and interaction, repetitive movements,…”
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Selective breeding for high alcohol consumption and response to nicotine: locomotor activity, dopaminergic in the mesolimbic system, and innate genetic differences in male and female alcohol-preferring, non-preferring, and replicate lines of high-alcohol drinking and low-alcohol drinking rats by Deehan, Gerald A., Hauser, Sheketha R., Getachew, Bruk, Waeiss, R. Aaron, Engleman, Eric A., Knight, Christopher P., McBride, William J., Truitt, William A., Bell, Richard L., Rodd, Zachary A.

“…Rationale There is evidence for a common genetic link between alcohol and nicotine dependence. Rodents selectively bred for high alcohol…”
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Epigenetic Changes Induced by High Glucose in Human Pancreatic Beta Cells by Alhazzaa, Rasha A., McKinley, Raechel E., Getachew, Bruk, Tizabi, Yousef, Heinbockel, Thomas, Csoka, Antonei B.

“…Epigenetic changes in pancreatic beta cells caused by sustained high blood glucose levels, as seen in prediabetic conditions, may contribute to the etiology of…”
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Low Vs. High Alcohol: Central Benefits Vs. Detriments by Tizabi, Yousef, Getachew, Bruk, Ferguson, Clifford L., Csoka, Antonei B., Thompson, Karl M., Gomez-Paz, Alejandra, Ruda-Kucerova, Jana, Taylor, Robert E.

“…The dose-dependent effects of alcohol, where the initial euphoric and stimulant effects initiated by the exposure to low ethanol levels can quickly lead to a…”
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Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson's Disease by Soares, Érica Novaes, Costa, Ana Carla Dos Santos, Ferrolho, Gabriel de Jesus, Ureshino, Rodrigo Portes, Getachew, Bruk, Costa, Silvia Lima, da Silva, Victor Diogenes Amaral, Tizabi, Yousef

“…Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by resting tremor, bradykinesia, rigidity, and postural instability that also…”
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Adolescent alcohol drinking interaction with the gut microbiome: implications for adult alcohol use disorder by Getachew, Bruk, Hauser, Sheketha R, Bennani, Samia, El Kouhen, Nacer, Sari, Youssef, Tizabi, Yousef

“…Reciprocal communication between the gut microbiota and the brain, commonly referred to as the "gut-brain-axis" is crucial in maintaining overall physiological…”
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Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction by Tizabi, Yousef, Getachew, Bruk, Hauser, Sheketha R, Tsytsarev, Vassiliy, Manhães, Alex C, da Silva, Victor Diogenes Amaral

“…Mood disorders and substance use disorder (SUD) are of immense medical and social concern. Although significant progress on neuronal involvement in mood and…”
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Ferroptosis as an emerging target in sickle cell disease by Fortuna, Vitor, Lima, Jaqueline, Oliveira, Gabriel F., Oliveira, Yasmin S., Getachew, Bruk, Nekhai, Sergei, Aschner, Michael, Tizabi, Yousef

“…[Display omitted] •Sickle Cell Disease (SCD) is an inherited blood disorder characterized by defective hemoglobin and chronic hemolysis resulting in…”
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The Effect of Citalopram on Genome-Wide DNA Methylation of Human Cells by Csoka, Antonei B., Heinbockel, Thomas, Varma, Sudhir, Ben-Sheetrit, Joseph, Getachew, Bruk, Kanherkar, Riya R., Tizabi, Yousef

“…Commonly used pharmaceutical drugs might alter the epigenetic state of cells, leading to varying degrees of long-term repercussions to human health. To test…”
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Effects of nicotine on depressive-like behavior and hippocampal volume of female WKY rats by Tizabi, Yousef, Hauser, Sheketha R., Tyler, Khandra Y., Getachew, Bruk, Madani, Reza, Sharma, Yukti, Manaye, Kebreten F.

“…The observed high incidence of smoking amongst depressed individuals has led to the hypothesis of ‘self medication” with nicotine in some of these patients…”
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Antidepressant-like effects of nicotine and reduced nicotinic receptor binding in the Fawn-Hooded rat, an animal model of co-morbid depression and alcoholism by Tizabi, Yousef, Getachew, Bruk, Rezvani, Amir H., Hauser, Sheketha R., Overstreet, David H.

“…A strong positive association between depression and alcoholism is evident in epidemiological studies. Curiously, the incidence of smoking (nicotine intake) is…”
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Antidepressant effects of moxidectin, an antiparasitic drug, in a rat model of depression by Getachew, Bruk, Tizabi, Yousef

“…•Moxidectin had lasting antidepressant effect in a rat model of depression.•Moxidectin caused an increase in hippocampal and frontal cortical BDNF…”
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Novel Pharmacotherapies in Parkinson’s Disease by Tizabi, Yousef, Getachew, Bruk, Aschner, Michael

“…Parkinson’s disease (PD), an age-related progressive neurodegenerative condition, is associated with loss of dopaminergic neurons in the substantia nigra pars…”
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Butyrate Protects and Synergizes with Nicotine against Iron- and Manganese-induced Toxicities in Cell Culture by Tizabi, Yousef, Getachew, Bruk, Aschner, Michael

“…Toxic exposures to heavy metals, such as iron (Fe) and manganese (Mn), can result in long-range neurological diseases and are therefore of significant…”
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