Search Results - "Gestl, Shelley A"

Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers by Cleary, Allison S., Leonard, Travis L., Gestl, Shelley A., Gunther, Edward J.

“…In a mouse model of tumours initiated by Wnt signalling in which a proportion of tumours are biclonal, that is, composed of basal and luminal clones with…”
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Different Oncogenes and Reproductive Histories Shape the Progression of Distinct Premalignant Clones in Multistage Mouse Breast Cancer Models by Linscott, Maryknoll P., Ren, Jerry R., Gestl, Shelley A., Gunther, Edward J.

“…A remote carcinogen exposure can predispose to breast cancer onset decades later, suggesting that carcinogen-induced mutations generate long-lived premalignant…”
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A Multistage Murine Breast Cancer Model Reveals Long-Lived Premalignant Clones Refractory to Parity-Induced Protection by Li, Shuo, Gestl, Shelley A, Gunther, Edward J

“…Breast cancers evolve in a multistage process that can span decades after a carcinogenic exposure. It follows that long-lived precursor breast lesions persist…”
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Dormant Wnt-Initiated Mammary Cancer Can Participate in Reconstituting Functional Mammary Glands by Gestl, Shelley A., Leonard, Travis L., Biddle, Jessica L., Debies, Michael T., Gunther, Edward J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Carcinogen-specific mutations in preferred Ras-Raf pathway oncogenes directed by strand bias by Keller, Ross R, Gestl, Shelley A, Lu, Amy Q, Hoke, Alicia, Feith, David J, Gunther, Edward J

“…Carcinogen exposures inscribe mutation patterns on cancer genomes and sometimes bias the acquisition of driver mutations toward preferred oncogenes,…”
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Basal but not Luminal Mammary Epithelial Cells Require PI3K/mTOR Signaling for Ras-Driven Overgrowth by PLICHTA, Kristin A, MATHERS, Jessica L, GESTL, Shelley A, GLICK, Adam B, GUNTHER, Edward J

“…The mammary ducts of humans and mice are comprised of two main mammary epithelial cell (MEC) subtypes: a surrounding layer of basal MECs and an inner layer of…”
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Class I alcohol dehydrogenase is highly expressed in normal human mammary epithelium but not in invasive breast cancer: Implications for breast carcinogenesis by TRIANO, Elise A, SLUSHER, Leslie B, ATKINS, Trudy A, BENESKI, John T, GESTL, Shelley A, ZOLFAGHARI, Reza, POLAVARAPU, Rathnagiri, FRAUENHOFFER, Elizabeth, WEISZ, Judith

“…Detoxification of ethanol can contribute to oxidative cellular and DNA damage and, thereby, to carcinogenesis. The potential relevance of this to breast…”
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Expression of UGT2B7, a UDP-Glucuronosyltransferase Implicated in the Metabolism of 4-Hydroxyestrone and All- Trans Retinoic Acid, in Normal Human Breast Parenchyma and in Invasive and in Situ Breast Cancers by Gestl, Shelley A., Green, Mitchell D., Shearer, Debra A., Frauenhoffer, Elizabeth, Tephly, Thomas R., Weisz, Judith

“…Glucuronidation, mediated by UDP-glucuronosyltransferases (UGTs), affects the actions and disposition of diverse endo- and xenobiotics. In the case of…”
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Abstract A34: Mammary-specific, doxycycline-regulated transposon mobilization for identifying driver genes in mouse models of breast cancer by Gestl, Shelley A., Gunther, Edward J.

“…Transposon-mediated mutagenesis offers a powerful tool for discovering genetic changes that contribute to cancer pathogenesis. Tissue-specific transposon…”
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Tumour cell heterogeneitymaintained by cooperating subclones in Wnt-driven mammary cancers by Cleary, Allison S, Leonard, Travis L, Gestl, Shelley A, Gunther, Edward J

“…Cancer genome sequencing studies indicate that a single breast cancer typically harbours multiple genetically distinct subclones. As carcinogenesis involves a…”
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Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19Arf/p53 pathway lesions but not p16Ink4a loss by Debies, Michael T., Gestl, Shelley A., Mathers, Jessica L., Mikse, Oliver R., Leonard, Travis L., Moody, Susan E., Chodosh, Lewis A., Cardiff, Robert D., Gunther, Edward J.

“…Breast cancers frequently progress or relapse during targeted therapy, but the molecular mechanisms that enable escape remain poorly understood. We elucidated…”
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Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19Arf/p53 pathway lesions but not p16 Ink4a loss by Debies, Michael T, Gestl, Shelley A, Mathers, Jessica L, Mikse, Oliver R, Leonard, Travis L, Moody, Susan E, Chodosh, Lewis A, Cardiff, Robert D, Gunther, Edward J

“…Breast cancers frequently progress or relapse during targeted therapy, but the molecular mechanisms that enable escape remain poorly understood. We elucidated…”
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Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by [p19.sup.Arf]/p53 pathway lesions but not [p16.sup.Ink4a] loss by Debies, Michael T, Gestl, Shelley A, Mathers, Jessica L, Mikse, Oliver R, Leonard, Travis L, Moody, Susan E, Chodosh, Lewis A, Cardiff, Robert D, Gunther, Edward J

“…Breast cancers frequently progress or relapse during targeted therapy, but the molecular mechanisms that enable escape remain poorly understood. We elucidated…”
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Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19^sup Arf^/p53 pathway lesions but not p16^sup Ink4a^ loss by Debies, Michael T, Gestl, Shelley A, Mathers, Jessica L, Mikse, Oliver R, Leonard, Travis L, Moody, Susan E, Chodosh, Lewis A, Cardiff, Robert D, Gunther, Edward J

“…Breast cancers frequently progress or relapse during targeted therapy, but the molecular mechanisms that enable escape remain poorly understood. We elucidated…”
Get full text