Search Results - "Geschwind, Dan"

Patient-Tailored, Connectivity-Based Forecasts of Spreading Brain Atrophy by Brown, Jesse A., Deng, Jersey, Neuhaus, John, Sible, Isabel J., Sias, Ana C., Lee, Suzee E., Kornak, John, Marx, Gabe A., Karydas, Anna M., Spina, Salvatore, Grinberg, Lea T., Coppola, Giovanni, Geschwind, Dan H., Kramer, Joel H., Gorno-Tempini, Maria Luisa, Miller, Bruce L., Rosen, Howard J., Seeley, William W.

“…Neurodegenerative diseases appear to progress by spreading via brain connections. Here we evaluated this transneuronal degeneration hypothesis by attempting to…”
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Network degeneration and dysfunction in presymptomatic C9ORF72 expansion carriers by Lee, Suzee E, Sias, Ana C, Mandelli, Maria Luisa, Brown, Jesse A, Brown, Alainna B, Khazenzon, Anna M, Vidovszky, Anna A, Zanto, Theodore P, Karydas, Anna M, Pribadi, Mochtar, Dokuru, Deepika, Coppola, Giovanni, Geschwind, Dan H, Rademakers, Rosa, Gorno-Tempini, Maria Luisa, Rosen, Howard J, Miller, Bruce L, Seeley, William W

“…Hexanucleotide repeat expansions in are the most common known genetic cause of familial and sporadic frontotemporal dementia and amyotrophic lateral sclerosis…”
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Divergent Whole-Genome Methylation Maps of Human and Chimpanzee Brains Reveal Epigenetic Basis of Human Regulatory Evolution by Zeng, Jia, Konopka, Genevieve, Hunt, Brendan G., Preuss, Todd M., Geschwind, Dan, Yi, Soojin V.

“…DNA methylation is a pervasive epigenetic DNA modification that strongly affects chromatin regulation and gene expression. To date, it remains largely unknown…”
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Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice by Ma, Chi Him Eddie, Omura, Takao, Cobos, Enrique J, Latrémolière, Alban, Ghasemlou, Nader, Brenner, Gary J, van Veen, Ed, Barrett, Lee, Sawada, Tomokazu, Gao, Fuying, Coppola, Giovanni, Gertler, Frank, Costigan, Michael, Geschwind, Dan, Woolf, Clifford J

“…Although peripheral nerves can regenerate after injury, proximal nerve injury in humans results in minimal restoration of motor function. One possible…”
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Combined Intrinsic and Extrinsic Neuronal Mechanisms Facilitate Bridging Axonal Regeneration One Year after Spinal Cord Injury by Kadoya, Ken, Tsukada, Shingo, Lu, Paul, Coppola, Giovanni, Geschwind, Dan, Filbin, Marie T., Blesch, Armin, Tuszynski, Mark H.

“…Despite advances in promoting axonal regeneration after acute spinal cord injury (SCI), elicitation of bridging axon regeneration after chronic SCI remains a…”
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Progranulin mutations as risk factors for Alzheimer disease by Perry, David C, Lehmann, Manja, Yokoyama, Jennifer S, Karydas, Anna, Lee, Jason Jiyong, Coppola, Giovanni, Grinberg, Lea T, Geschwind, Dan, Seeley, William W, Miller, Bruce L, Rosen, Howard, Rabinovici, Gil

“…Mutations in the progranulin gene are known to cause diverse clinical syndromes, all attributed to frontotemporal lobar degeneration. We describe 2 patients…”
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Molecular alterations in areas generating fast ripples in an animal model of temporal lobe epilepsy by Winden, Kellen D, Bragin, Anatol, Engel, Jerome, Geschwind, Dan H

“…Abstract The molecular basis of epileptogenesis is poorly characterized. Studies in humans and animal models have identified an electrophysiological signature…”
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C9ORF72 repeat expansions in cases with previously identified pathogenic mutations by van Blitterswijk, Marka, Baker, Matthew C, DeJesus-Hernandez, Mariely, Ghidoni, Roberta, Benussi, Luisa, Finger, Elizabeth, Hsiung, Ging-Yuek R, Kelley, Brendan J, Murray, Melissa E, Rutherford, Nicola J, Brown, Patricia E, Ravenscroft, Thomas, Mullen, Bianca, Ash, Peter E.A, Bieniek, Kevin F, Hatanpaa, Kimmo J, Karydas, Anna, Wood, Elisabeth McCarty, Coppola, Giovanni, Bigio, Eileen H, Lippa, Carol, Strong, Michael J, Beach, Thomas G, Knopman, David S, Huey, Edward D, Mesulam, Marsel, Bird, Thomas, White, Charles L, Kertesz, Andrew, Geschwind, Dan H, Van Deerlin, Vivianna M, Petersen, Ronald C, Binetti, Giuliano, Miller, Bruce L, Petrucelli, Leonard, Wszolek, Zbigniew K, Boylan, Kevin B, Graff-Radford, Neill R, Mackenzie, Ian R, Boeve, Bradley F, Dickson, Dennis W, Rademakers, Rosa

“…OBJECTIVE:To identify potential genetic modifiers contributing to the phenotypic variability that is detected in patients with repeat expansions in chromosome…”
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Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C→T (Arg493X) mutation: an international initiative by Rademakers, Rosa, PhD, Baker, Matt, BSc, Gass, Jennifer, BS, Adamson, Jennifer, BS, Huey, Edward D, MD, Momeni, Parastoo, PhD, Spina, Salvatore, MD, Coppola, Giovanni, MD, Karydas, Anna M, BA, Stewart, Heather, PhD, Johnson, Nancy, PhD, Hsiung, Ging-Yuek, MD, Kelley, Brendan, MD, Kuntz, Karen, RN, Steinbart, Ellen, MA, Wood, Elisabeth McCarty, MS, Yu, Chang-En, PhD, Josephs, Keith, MD, Sorenson, Eric, MD, Womack, Kyle B, MD, Weintraub, Sandra, PhD, Pickering-Brown, Stuart M, PhD, Schofield, Peter R, DSc, Brooks, William S, MBBS, Van Deerlin, Vivianna M, MD, Snowden, Julie, PhD, Clark, Christopher M, MD, Kertesz, Andrew, MD, Boylan, Kevin, MD, Ghetti, Bernardino, MD, Neary, David, FRCP, Schellenberg, Gerard D, PhD, Beach, Thomas G, FRCPC, Mesulam, Marsel, MD, Mann, David, PhD, Grafman, Jordan, PhD, Mackenzie, Ian R, MD, Feldman, Howard, MD, Bird, Thomas, MD, Petersen, Ron, MD, Knopman, David, MD, Boeve, Bradley, MD, Geschwind, Dan H, MD, Miller, Bruce, MD, Wszolek, Zbigniew, MD, Lippa, Carol, MD, Bigio, Eileen H, MD, Dickson, Dennis, MD, Graff-Radford, Neill, FRCP, Hutton, Mike, PhD

“…Summary Background The progranulin gene ( GRN ) is mutated in 5–10% of patients with frontotemporal lobar degeneration (FTLD) and in about 20% of patients with…”
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Mutation-Specific Functional Impairments in Distinct Tau Isoforms of Hereditary FTDP-17 by Hong, Ming, Zhukareva, Victoria, Vogelsberg-Ragaglia, Vanessa, Wszolek, Zbigniew, Reed, Lee, Miller, Bruce I., Geschwind, Dan H., Bird, Thomas D., McKeel, Daniel, Goate, Alison, Morris, John C., Wilhelmsen, Kirk C., Schellenberg, Gerard D., Trojanowski, John Q., Virginia M.-Y. Lee

“…Tau proteins aggregate as cytoplasmic inclusions in a number of neurodegenerative diseases, including Alzheimer's disease and hereditary frontotemporal…”
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Genes and the long and winding road to cortical construction and cognition by Ross, M. Elizabeth, Geschwind, Dan

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GENSAT: a genomic resource for neuroscience research by Geschwind, Dan

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238. Transcriptome-Wide Isoform-Level Dysregulation in Schizophrenia, Autism, and Bipolar Disorder by Gandal, Michael, Pinto, Dalila, Iakoucheva, Lilia, Liu, Chunyu, Geschwind, Dan

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Understanding the biological basis of psychiatric disease: What’s next? by Liston, Conor, Roberts, Angela, Dzirasa, Kafui, Geschwind, Dan, Ahmari, Susanne E., Lüscher, Christian

“…Psychiatric disease is one of the greatest health challenges of our time. The pipeline for conceptually novel therapeutics remains low, in part because…”
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Resting-State Functional Connectivity in Autism Spectrum Disorders: A Review by Hull, Jocelyn V, Dokovna, Lisa B, Jacokes, Zachary J, Torgerson, Carinna M, Irimia, Andrei, Van Horn, John Darrell

“…Ongoing debate exists within the resting-state functional MRI (fMRI) literature over how intrinsic connectivity is altered in the autistic brain, with reports…”
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Conditioning lesions before or after spinal cord injury recruit broad genetic mechanisms that sustain axonal regeneration: Superiority to camp-mediated effects by Blesch, Armin, Lu, Paul, Tsukada, Shingo, Alto, Laura Taylor, Roet, Kasper, Coppola, Giovanni, Geschwind, Dan, Tuszynski, Mark H.

“…Previous studies indicate that peripheral nerve conditioning lesions significantly enhance central axonal regeneration via modulation of cAMP-mediated…”
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Transcriptional Architecture of the Primate Neocortex by Bernard, Amy, Lubbers, Laura S., Tanis, Keith Q., Luo, Rui, Podtelezhnikov, Alexei A., Finney, Eva M., McWhorter, Mollie M.E., Serikawa, Kyle, Lemon, Tracy, Morgan, Rebecca, Copeland, Catherine, Smith, Kimberly, Cullen, Vivian, Davis-Turak, Jeremy, Lee, Chang-Kyu, Sunkin, Susan M., Loboda, Andrey P., Levine, David M., Stone, David J., Hawrylycz, Michael J., Roberts, Christopher J., Jones, Allan R., Geschwind, Daniel H., Lein, Ed S.

“…Genome-wide transcriptional profiling was used to characterize the molecular underpinnings of neocortical organization in rhesus macaque, including cortical…”
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Poly(GP), neurofilament and grey matter deficits in C9orf72 expansion carriers by Meeter, Lieke H.H., Gendron, Tania F., Sias, Ana C., Jiskoot, Lize C., Russo, Silvia P., Donker Kaat, Laura, Papma, Janne M., Panman, Jessica L., Ende, Emma L., Dopper, Elise G., Franzen, Sanne, Graff, Caroline, Boxer, Adam L., Rosen, Howard J., Sanchez‐Valle, Raquel, Galimberti, Daniela, Pijnenburg, Yolande A. L., Benussi, Luisa, Ghidoni, Roberta, Borroni, Barbara, Laforce, Robert, del Campo, Marta, Teunissen, Charlotte E., Minkelen, Rick, Rojas, Julio C., Coppola, Giovanni, Geschwind, Dan H., Rademakers, Rosa, Karydas, Anna M., Öijerstedt, Linn, Scarpini, Elio, Binetti, Giuliano, Padovani, Alessandro, Cash, David M., Dick, Katrina M., Bocchetta, Martina, Miller, Bruce L., Rohrer, Jonathan D., Petrucelli, Leonard, Swieten, John C., Lee, Suzee E.

“…Objective To evaluate poly(GP), a dipeptide repeat protein, and neurofilament light chain (NfL) as biomarkers in presymptomatic C9orf72 repeat expansion…”
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Brain volumetric deficits in MAPT mutation carriers: a multisite study by Chu, Stephanie A., Flagan, Taru M., Staffaroni, Adam M., Jiskoot, Lize C., Deng, Jersey, Spina, Salvatore, Zhang, Liwen, Sturm, Virginia E., Yokoyama, Jennifer S., Seeley, William W., Papma, Janne M., Geschwind, Dan H., Rosen, Howard J., Boeve, Bradley F., Boxer, Adam L., Heuer, Hilary W., Forsberg, Leah K., Brushaber, Danielle E., Grossman, Murray, Coppola, Giovanni, Dickerson, Bradford C., Bordelon, Yvette M., Faber, Kelley, Feldman, Howard H., Fields, Julie A., Fong, Jamie C., Foroud, Tatiana, Gavrilova, Ralitza H., Ghoshal, Nupur, Graff‐Radford, Neill R., Hsiung, Ging‐Yuek Robin, Huey, Edward D., Irwin, David J., Kantarci, Kejal, Kaufer, Daniel I., Karydas, Anna M., Knopman, David S., Kornak, John, Kramer, Joel H., Kukull, Walter A., Lapid, Maria I., Litvan, Irene, Mackenzie, Ian R.A., Mendez, Mario F., Miller, Bruce L., Onyike, Chiadi U., Pantelyat, Alexander Y., Rademakers, Rosa, Marisa Ramos, Eliana, Roberson, Erik D., Carmela Tartaglia, Maria, Tatton, Nadine A., Toga, Arthur W., Vetor, Ashley, Weintraub, Sandra, Wong, Bonnie, Wszolek, Zbigniew K., Van Swieten, John C., Lee, Suzee E.

“…Objective MAPT mutations typically cause behavioral variant frontotemporal dementia with or without parkinsonism. Previous studies have shown that symptomatic…”
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Conditioning lesions before or after spinal cord injury recruit broad genetic mechanisms that sustain axonal regeneration: Superiority to camp-mediated effects : PLASTICITY AFTER SCI by BLESCH, Armin, LU, Paul, TSUKADA, Shingo, TAYLOR ALTO, Laura, ROET, Kasper, COPPOLA, Giovanni, GESCHWIND, Dan, TUSZYNSKI, Mark H

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