Search Results - "Gescher, Andreas J."

Clinical trials of resveratrol by Patel, Ketan R., Scott, Edwina, Brown, Victoria A., Gescher, Andreas J., Steward, William P., Brown, Karen

“…An expanding body of preclinical evidence suggests resveratrol has the potential to impact a variety of human diseases. To translate encouraging experimental…”
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Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis by BROWN, Victoria A, PATEL, Ketan R, BROWN, Karen, STEWARD, William P, GESCHER, Andreas J, BRENNER, Dean E, VISKADURAKI, Maria, CROWELL, James A, PERLOFF, Marjorie, BOOTH, Tristan D, VASILININ, Grygoriy, SEN, Ananda, SCHINAS, Anna Maria, PICCIRILLI, Gianfranca

“…Resveratrol, a naturally occurring polyphenol, has cancer chemopreventive properties in preclinical models. It has been shown to downregulate the levels of…”
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Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice by Cai, Hong, Scott, Edwina, Kholghi, Abeer, Andreadi, Catherine, Rufini, Alessandro, Karmokar, Ankur, Britton, Robert G, Horner-Glister, Emma, Greaves, Peter, Jawad, Dhafer, James, Mark, Howells, Lynne, Ognibene, Ted, Malfatti, Michael, Goldring, Christopher, Kitteringham, Neil, Walsh, Joanne, Viskaduraki, Maria, West, Kevin, Miller, Andrew, Hemingway, David, Steward, William P, Gescher, Andreas J, Brown, Karen

“…Resveratrol is widely promoted as a potential cancer chemopreventive agent, but a lack of information on the optimal dose prohibits rationally designed trials…”
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Clinical Pharmacology of Resveratrol and Its Metabolites in Colorectal Cancer Patients by PATEL, Ketan R, BROWN, Victoria A, BRENNER, Dean E, STEWARD, William P, GESCHER, Andreas J, BROWN, Karen, JONES, Donald J. L, BRITTON, Robert G, HEMINGWAY, David, MILLER, Andrew S, WEST, Kevin P, BOOTH, Tristan D, PERLOFF, Marjorie, CROWELL, James A

“…Resveratrol is a phytochemical with chemopreventive activity in preclinical rodent models of colorectal carcinogenesis. Antiproliferation is one of the many…”
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Resveratrol in human cancer chemoprevention - Choosing the 'right' dose by Scott, Edwina, Steward, William P., Gescher, Andreas J., Brown, Karen

“…There is now robust preclinical evidence to suggest that resveratrol possesses cancer chemopreventive properties. A series of clinical pilot studies has…”
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Phase I Dose Escalation Pharmacokinetic Study in Healthy Volunteers of Resveratrol, a Potential Cancer Chemopreventive Agent by BOOCOCK, David J, FAUST, Guy E. S, STEWARD, William P, BRENNER, Dean E, PATEL, Ketan R, SCHINAS, Anna M, BROWN, Victoria A, DUCHARME, Murray P, BOOTH, Tristan D, CROWELL, James A, PERLOFF, Marjorie, GESCHER, Andreas J

“…The red grape constituent resveratrol possesses cancer chemopreventive properties in rodents. The hypothesis was tested that, in healthy humans, p.o…”
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Rapid Analysis of Curcumin and Curcumin Metabolites in Rat Biomatrices Using a Novel Ultraperformance Liquid Chromatography (UPLC) Method by Marczylo, Timothy H, Steward, William P, Gescher, Andreas J

“…The bioavailability of the putative cancer chemopreventive agent curcumin is limited, making measurement either in target tissues or in biofluids difficult and…”
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Consumption of the Putative Chemopreventive Agent Curcumin by Cancer Patients: Assessment of Curcumin Levels in the Colorectum and their Pharmacodynamic Consequences by GARCEA, Giuseppe, BERRY, David P, JONES, Donald J. L, SINGH, Raj, DENNISON, Ashley R, FARMER, Peter B, SHARMA, Ricky A, STEWARD, William P, GESCHER, Andreas J

“…Curcumin, a constituent of the spice turmeric, has been shown to reduce the adenoma burden in rodent models of colorectal cancer accompanied by a reduction of…”
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Prolonged Biologically Active Colonic Tissue Levels of Curcumin Achieved After Oral Administration—A Clinical Pilot Study Including Assessment of Patient Acceptability by IRVING, Glen R. B, HOWELLS, Lynne M, HEMINGWAY, David, MILLER, Andrew S, BROWN, Karen, GESCHER, Andreas J, STEWARD, William P, SALE, Stewart, KRALJ-HANS, Ines, ATKIN, Wendy S, CLARK, Susan K, BRITTON, Robert G, JONES, Donald J. L, SCOTT, Edwina N, BERRY, David P

“…Curcumin, the main constituent of turmeric, is suspected to possess cancer chemopreventive properties. Pharmacokinetic and pharmacodynamic parameters have been…”
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Dose escalation and pharmacokinetic study of nanoparticle curcumin… by Kanai et al., CCP 69:65–70, 2012 by Gescher, Andreas J.

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Do anthocyanins and anthocyanidins, cancer chemopreventive pigments in the diet, merit development as potential drugs? by Thomasset, Sarah, Teller, Nicole, Cai, Hong, Marko, Doris, Berry, David P, Steward, William P, Gescher, Andreas J

“…Anthocyanins, plant pigments in fruits and berries, have been shown to delay cancer development in rodent models of carcinogenesis, especially those of the…”
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Pharmacokinetics and metabolism of the putative cancer chemopreventive agent cyanidin-3-glucoside in mice by Marczylo, Timothy H, Cooke, Darren, Brown, Karen, Steward, William P, Gescher, Andreas J

“…Purpose Cyanidin-3-glucoside (C3G), an anthocyanin component of fruits and berries, possesses cancer chemopreventive properties in mouse models of…”
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Metabolism of the Cancer Chemopreventive Agent Curcumin in Human and Rat Intestine by IRESON, Christopher R, JONES, Donald J. L, ORR, Samantha, COUGHTRIE, Michael W. H, BOOCOCK, David J, WILLIAMS, Marion L, FARMER, Peter B, STEWARD, William P, GESCHER, Andreas J

“…Curcumin, the yellow pigment in turmeric, prevents malignancies in the intestinal tract of rodents. It is under clinical evaluation as a potential colon cancer…”
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Pharmacodynamic and Pharmacokinetic Study of Oral Curcuma Extract in Patients with Colorectal Cancer by SHARMA, Ricky A, MCLELLAND, Heather R, HILL, Kirsti A, IRESON, Christopher R, EUDEN, Stephanie A, MANSON, Margaret M, PIRMOHAMED, Munir, MARNETT, Lawrence J, GESCHER, Andreas J, STEWARD, William P

“…Curcuma spp. extracts, particularly the dietary polyphenol curcumin, prevent colon cancer in rodents. In view of the sparse information on the pharmacodynamics…”
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Pilot Study of Oral Silibinin, a Putative Chemopreventive Agent, in Colorectal Cancer Patients: Silibinin Levels in Plasma, Colorectum, and Liver and Their Pharmacodynamic Consequences by HOH, Carmen, BOOCOCK, David, GARCEA, Giuseppe, FARMER, Peter B, STEWARD, William P, GESCHER, Andreas J, MARCZYLO, Tim, SINGH, Rajinder, BERRY, David P, DENNISON, Ashley R, HEMINGWAY, David, MILLER, Andrew, WEST, Kevin, EUDEN, Stephanie

“…Silibinin, a flavonolignan from milk thistle, has intestinal cancer chemopreventive efficacy in rodents. It is a strong antioxidant and modulates the…”
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Pilot study of oral anthocyanins for colorectal cancer chemoprevention by Thomasset, Sarah, Berry, David P, Cai, Hong, West, Kevin, Marczylo, Tim H, Marsden, Debbie, Brown, Karen, Dennison, Ashley, Garcea, Giuseppe, Miller, Andrew, Hemingway, David, Steward, William P, Gescher, Andreas J

“…Naturally occurring anthocyanins possess colorectal cancer chemopreventive properties in rodent models. We investigated whether mirtocyan, an anthocyanin-rich…”
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Chemopreventive Efficacy and Pharmacokinetics of Curcumin in the Min/+ Mouse, a Model of Familial Adenomatous Polyposis by PERKINS, Sarah, VERSCHOYLE, Richard D, HILL, Kirsti, PARVEEN, Ifat, THREADGILL, Michael D, SHARMA, Ricky A, WILLIAMS, Marion L, STEWARD, William P, GESCHER, Andreas J

“…Curcumin, the major yellow pigment in turmeric, prevents the development of adenomas in the intestinal tract of the C57Bl/6J Min/+ mouse, a model of human…”
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Differential modulation of cyclooxygenase-mediated prostaglandin production by the putative cancer chemopreventive flavonoids tricin, apigenin and quercetin by AL-FAYEZ, Mohammad, HONG CAI, TUNSTALL, Richard, STEWARD, William P, GESCHER, Andreas J

“…Diet-derived flavonoids possess cancer chemopreventive properties in preclinical models. The knowledge of the pharmacology of most flavonoids is insufficient…”
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Flavones as colorectal cancer chemopreventive agents--phenol-o-methylation enhances efficacy by Cai, Hong, Sale, Stewart, Schmid, Ralf, Britton, Robert G, Brown, Karen, Steward, William P, Gescher, Andreas J

“…Flavonoids occur ubiquitously in plants, and some possess preclinical cancer chemopreventive activity. Little is known about molecular features that mediate…”
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Simultaneous determination of 8-oxo-2′-deoxyguanosine and 8-oxo-2′-deoxyadenosine in DNA using online column-switching liquid chromatography/tandem mass spectrometry by Singh, Rajinder, Teichert, Friederike, Verschoyle, Richard D., Kaur, Balvinder, Vives, Montserrat, Sharma, Ricky A., Steward, William P., Gescher, Andreas J., Farmer, Peter B.

“…Sensitive and reliable methods are required for the assessment of oxidative DNA damage, which can result from reactive oxygen species that are generated…”
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