Search Results - "Gerwin, B I"

ErbB‐2 kinase is required for constitutive stat 3 activation in malignant human lung epithelial cells by Fernandes, Audrey, Hamburger, Anne W., Gerwin, Brenda I.

“…Overexpression of the growth factor receptor ErbB‐2/Her2/Neu has been implicated in the development of non‐small‐cell lung cancer. We have reported that the…”
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Human mesothelioma samples overexpress both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (NOS2) : In vitro antiproliferative effects of a COX-2 inhibitor by MARROGI, A, PASS, H. I, KHAN, M, METHENY-BARLOW, L. J, HARRIS, C. C, GERWIN, B. I

“…Accumulating data demonstrate overexpression of both inducible NO synthase (NOS2) and cyclooxygenase-2 (COX2) in many epithelial neoplasias. In addition,…”
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p53 and kirsten-ras mutations in human mesothelioma cell lines by METCALF, R. A, WELSH, J. A, HARRIS, C. C, BENNETT, W.P, SEDDON, M. B, LEHMAN, T. A, PELIN, K, LINNAINMAA, K, TAMMILEHTO, L, MATTSON, K, GERWIN, B. I

“…Twenty cell lines from 17 individuals with malignant mesothelioma have been examined for p53 alterations by direct sequencing of genomic DNA, by evaluation of…”
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Transformation of Human Bronchial Epithelial Cells by Infection with SV40 or Adenovirus-12 SV40 Hybrid Virus, or Transfection via Strontium Phosphate Coprecipitation with a Plasmid Containing SV40 Early Region Genes by REDDEL, R. R, YANG KE, GERWIN, B. I, MCMENAMIN, M. G, LECHNER, J. F, SU, R. T, BRASH, D. E, JOO-BAE PARK, RHIM, J. S, HARRIS, C. C

“…Normal human bronchial epithelial cells were infected with SV40 virus or an adenovirus 12-SV40 hybrid virus, or transfected via strontium phosphate…”
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Paradoxical Effects of Platelet-Derived Growth Factor-A Overexpression in Malignant Mesothelioma . Antiproliferative Effects In Vitro and Tumorigenic Stimulation In Vivo by Metheny-Barlow, Linda J, Flynn, Barbara, van Gijssel, Hilde E, Marrogi, Aizen, Gerwin, Brenda I

“…Malignant mesothelioma is associated with asbestos exposure and remains resistant to all therapeutic intervention. Previous studies have suggested an enhancing…”
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High levels of MDM2 are not correlated with the presence of wild-type p53 in human malignant mesothelioma cell lines by UNGAR, S, VAN DE MEEREN, A, TAMMILEHTO, L, LINNAINMAA, K, MATTSON, K, GERWIN, B. I

“…Prior analysis of 20 human mesothelioma cell lines for p53 status revealed only two mutations and one p53 null cell line, although p53 expression was detected…”
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The role of transforming growth factor alpha production and ErbB-2 overexpression in induction of tumorigenicity of lung epithelial cells by HAMBURGER, A. W, FERNANDES, A, MURAKAMI, M, GERWIN, B. I

“…Over-expression of erbB-2 is associated with shortened survival of patients with lung adenocarcinomas. We demonstrated that human lung epithelial cells,…”
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Production of epidermal growth factor related ligands in tumorigenic and benign human lung epithelial cells by Fernandes, Audrey M., Hamburger, Anne W., Gerwin, Brenda I.

“…We recently demonstrated that human lung epithelial cells, overexpressing ErbB-2, formed tumors in nude mice only when high levels of transforming growth…”
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Establishment of a human in vitro mesothelial cell model system for investigating mechanisms of asbestos-induced mesothelioma by Ke, Y, Reddel, RR, Gerwin, BI, Reddel, HK, Somers, AN, McMenamin, MG, LaVeck, MA, Stahel, RA, Lechner, JF, Harris, CC

“…Normal human mesothelial (NHM) cells were transfected with a plasmid containing SV40 early region DNA. Individual colonies of transformed cells from several…”
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Asbestos induction of extended lifespan in normal human mesothelial cells: interindividual susceptibility and SV40 T antigen by Xu, Lixin, Flynn, Barbara J., Ungar, Susan, Pass, Harvey I., Linnainmaa, Kaija, Mattson, Karin, Gerwin, Brenda I.

“…Normal human mesothelial cells from individual donors were studied for susceptibility to asbestos-induction of apoptosis and generation of an extended lifespan…”
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TGF-beta 1 modulation of urokinase and PAI-1 expression in human bronchial epithelial cells by Gerwin, B I, Keski-Oja, J, Seddon, M, Lechner, J F, Harris, C C

“…Normal human bronchial epithelial (NHBE) cells respond to signals initiated by the binding of transforming growth factor-beta type 1 (TGF-beta 1) to its…”
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Asbestos-related malignant mesothelioma: growth, cytology, tumorigenicity and consistent chromosome findings in cell lines from five patients by Pelin-Enlund, K, Husgafvel-Pursiainen, K, Tammilehto, L, Klockars, M, Jantunen, K, Gerwin, B I, Harris, C C, Tuomi, T, Vanhala, E, Mattson, K

“…Seven mesothelioma cell lines were established from clinical specimens from five patients with asbestos-related malignant pleural mesothelioma. The cells in…”
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Stimulation of DNA synthesis in cultured primary human mesothelial cells by specific growth factors by Gabrielson, E W, Gerwin, B I, Harris, C C, Roberts, A B, Sporn, M B, Lechner, J F

“…Monolayer cultures of human mesothelial cells made quiescent by serum deprivation are induced to undergo one round of DNA synthesis by platelet-derived growth…”
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Asbestos and the mesothelial cell: a molecular trail to mitogenic stimuli and suppressor gene suspects by Gerwin, B I

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Overexpression of the p185erB-2 tyrosine kinase growth factor receptor: control or chaos by Gerwin, B I

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Comparison of production of transforming growth factor-β and platelet-derived growth factor by normal human mesothelial cells and mesothelioma cell lines by GERWIN, B. I, LECHNER, J. F, REDDEL, R. R, ROBERTS, A. B, ROBBINS, K. C, GABRIELSON, E. W, HARRIS, C. C

“…Steady state mRNA levels for transforming growth factor beta, platelet-derived growth factor (PDGF) A-chain, and PDGF B-chain were measured in normal human…”
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Biological consequences of overexpression of a transfected c-erbB-2 gene in immortalized human bronchial epithelial cells by NOGUCHI, M, MURAKAMI, M, BENNETT, W, LUPU, R, HUI, F. JR, HARRIS, C. C, GERWIN, B. I

“…In order to examine the effects of the overexpression of c-erbB-2 (HER-2, neu) on human bronchial epithelial cells, a human c-erbB-2 expression vector was…”
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SV40-induced immortalization and ras-transformation of human bronchial epithelial cells by Reddel, R R, De Silva, R, Duncan, E L, Rogan, E M, Whitaker, N J, Zahra, D G, Ke, Y, McMenamin, M G, Gerwin, B I, Harris, C C

“…Non-tumorigenic SV40-immortalized human cells may be transformed to tumorigenicity by activated oncogenes, but the molecular genetics of this process are still…”
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Development of tumorigenicity in simian virus 40-immortalized human bronchial epithelial cell lines by REDDEL, R. R, SALGHETTI, S. E, WILLEY, J. C, OHNUKI, Y, YANG KE, GERWIN, B. I, LECHNER, J. F, HARRIS, C. C

“…Of five SV40-transformed clonal human bronchial epithelial cell lines previously shown to be nontumorigenic at early passages (R. R. Reddel et al., Cancer…”
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Human bronchial epithelial cells with integrated SV40 virus T antigen genes retain the ability to undergo squamous differentiation by Ke, Y, Reddel, R R, Gerwin, B I, Miyashita, M, McMenamin, M, Lechner, J F, Harris, C C

“…Human bronchial epithelial cells transformed by either DNA virus infection (SV40 or Adenovirus 12-SV40 hybrid virus) or transfection with the SV40 large T…”
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