Search Results - "Gerwick, W. H."

Chemical and bioactive natural products from Microthyriaceae sp., an endophytic fungus from a tropical grass by Almeida, C, Ortega, H, Higginbotham, S, Spadafora, C, Arnold, A.E, Coley, P.D, Kursar, T.A, Gerwick, W.H, Cubilla‐Rios, L

“…In screening for natural products with antiparasitic activity, an endophytic fungus, strain F2611, isolated from above‐ground tissue of the tropical grass…”
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The neurotoxic lipopeptide kalkitoxin interacts with voltage-sensitive sodium channels in cerebellar granule neurons by LePage, K.T., Goeger, D., Yokokawa, F., Asano, T., Shioiri, T., Gerwick, W.H., Murray, T.F.

“…The marine neurotoxin kalkitoxin, a thiazoline-containing lipid derived from the pantropical marine cyanobacterium Lyngbya majuscula, was assayed for…”
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Antillatoxin is a Marine Cyanobacterial Toxin That Potently Activates Voltage-Gated Sodium Channels by Li, W. I., Berman, F. W., Okino, T., Yokokawa, F., Shioiri, T., Gerwick, W. H., Murray, T. F.

“…Antillatoxin (ATX) is a lipopeptide derived from the pantropical marine cyanobacterium Lyngbya majuscula. ATX is neurotoxic in primary cultures of rat…”
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Structure, Synthesis, and Biological Properties of Kalkitoxin, a Novel Neurotoxin from the Marine Cyanobacterium Lyngbya majuscula by WU, Min, OKINO, Tatsufumi, NOGLE, Lisa M., MARQUEZ, Brian L., WILLIAMSON, R. Thomas, SITACHITTA, Namthip, BERMAN, Frederick W., MURRAY, Thomas F., MCGOUGH, Kevin, JACOBS, Robert, COLSEN, Kimberly, ASANO, Toshinobu, YOKOKAWA, Fumiaki, SHIOIRI, Takayuki, GERWICK, William H.

“…Cyanobacteria from a diversity of marine and freshwater habitats are known to produce neurotoxic secondary metabolites. Herein, we describe the complete…”
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Scytonemin--a marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases by Stevenson, C S, Capper, E A, Roshak, A K, Marquez, B, Grace, K, Gerwick, W H, Jacobs, R S, Marshall, L A

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Grenadadiene and Grenadamide, Cyclopropyl-Containing Fatty Acid Metabolites from the Marine Cyanobacterium Lyngbya majuscula by Sitachitta, Namthip, Gerwick, William H

“…Grenadadiene (1), debromogrenadiene (2), and grenadamide (3), three structurally unique cyclopropyl-containing metabolites, were isolated from the organic…”
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Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity by Berman, F.W, Gerwick, W.H, Murray, T.F

“…Curacin-A, antillatoxin and kalkitoxin, natural products from the marine cyanobacterium Lyngbya majuscula, were tested for neurotoxicity in primary cultures of…”
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Barbamide, a Chlorinated Metabolite with Molluscicidal Activity from the Caribbean Cyanobacterium Lyngbya majuscula by Orjala, Jimmy, Gerwick, William H

“…The lipid extract from a Curaçao collection of the marine cyanobacterium Lyngbya majuscula was toxic to the mollusc Biomphalaria glabrata. Subsequent…”
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Characterization of the Preferred Stereochemistry for the Neuropharmacologic Actions of Antillatoxin by Li, W. I, Marquez, B. L, Okino, T, Yokokawa, F, Shioiri, T, Gerwick, W. H, Murray, T. F

“…Antillatoxin is a potent ichthyotoxin and cytotoxin previously discovered from the marine cyanobacterium Lyngbya majuscula. Ensuing studies of its mechanism of…”
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Arachidonoylserotonin and Other Novel Inhibitors of Fatty Acid Amide Hydrolase by Bisogno, T., Melck, D., De Petrocellis, L., Bobrov, M.Yu, Gretskaya, N.M., Bezuglov, V.V., Sitachitta, N., Gerwick, W.H., Marzo, V.Di

“…Fatty acid amide hydrolase (FAAH) catalyzes the hydrolysis of bioactive fatty acid amides and esters such as the endogenous cannabinoid receptor ligands,…”
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Tanikolide, a toxic and antifungal lactone from the marine cyanobacterium Lyngbya majuscula by Singh, I.P, Milligan, K.E, Gerwick, W.H

“…A new brine-shrimp toxic and antifungal compound, tanikolide 1, has been isolated from the lipid extract of a Madagascan collection of the marine…”
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Somamides A and B, Two New Depsipeptide Analogues of Dolastatin 13 from a Fijian Cyanobacterial Assemblage of Lyngbya majuscula and Schizothrix Species by NOGLE, Lisa M., WILLIAMSON, R. Thomas, GERWICK, William H.

“…Somamides A (1) and B (2) were isolated from assemblages of the marine cyanobacteria Lyngbya majusculaand Schizothrix sp. from the Fijian Islands. These new…”
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Hermitamides A and B, Toxic Malyngamide-Type Natural Products from the Marine Cyanobacterium Lyngbya majuscula by Tan, Lik Tong, Okino, Tatsufumi, Gerwick, William H

“…A Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula yielded two new and toxic natural products, hermitamides A (1) and B (2). The…”
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Carmabins A and B, New Lipopeptides from the Caribbean Cyanobacterium Lyngbya majuscula by Hooper, Gregory J, Orjala, Jimmy, Schatzman, Randall C, Gerwick, William H

“…Carmabins A and B have been isolated as linear lipotetrapeptides from the BuOH extract of the marine cyanobacterium Lyngbya majuscula. The planar structures…”
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Yanucamides A and B, Two New Depsipeptides from an Assemblage of the Marine Cyanobacteria Lyngbya majuscula and Schizothrix Species by SITACHITTA, Namthip, WILLIAMSON, R. Thomas, GERWICK, William H.

“…Yanucamides A (1) and B (2) were isolated from the lipid extract of a Lyngbya majuscula and Schizothrixsp. assemblage collected at Yanuca Island, Fiji. The…”
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Antillatoxin B, a Neurotoxic Lipopeptide from the Marine Cyanobacterium Lyngbya majuscula by NOGLE, Lisa M., OKINO, Tatsufumi, GERWICK, William H.

“…Bioassay-guided fractionation of organic extracts from two Lyngbya majuscula collections led to the isolation of a new secondary metabolite, antillatoxin B, an…”
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The structure of scytonemin, an ultraviolet sunscreen pigment from the sheaths of cyanobacteria by Proteau, P J, Gerwick, W H, Garcia-Pichel, F, Castenholz, R

“…Despite knowledge of the existence of the pigment called scytonemin for over 100 years, its structure has remained unsolved until now. This pigment, the first…”
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Two New Malyngamides from a Madagascan Lyngbya majuscula by Milligan, Kenneth E, Márquez, Brian, Williamson, R. Thomas, Davies-Coleman, Michael, Gerwick, William H

“…The lipid extract of a Madagascan Lyngbya majuscula has yielded malyngamides Q and R, both amides of 7-methoxytetradec-4-enoic acid. The isolation of these…”
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Kalkipyrone, a Toxic γ-Pyrone from an Assemblage of the Marine Cyanobacteria Lyngbya majuscula and Tolypothrix sp by Graber, Melodie A, Gerwick, William H

“…Kalkipyrone, a novel α-methoxy-β,β‘-dimethyl-γ-pyrone possessing an alkyl side chain, was isolated from an assemblage of the marine cyanobacteria Lyngbya…”
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Curacin D, aN antimitotic agent from the marine Cyanobacterium Lyngbya majuscula by Márquez, Brian, Verdier-Pinard, Pascal, Hamel, Ernest, Gerwick, William H.

“…Curacin D is a novel brine shrimp toxic metabolite isolated from a Virgin Islands collection of the marine cyanobacterium Lyngbya majuscula. Structure…”
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