Search Results - "Gerwert, Klaus"

Channelrhodopsin reveals its dark secrets by Gerwert, Klaus

“…A high-resolution structure of channelrhodopsin 2 provides key insights for optogenetics A key element of information processing in the brain is the flow of…”
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Proton transfer via a transient linear water-molecule chain in a membrane protein by Freier, Erik, Wolf, Steffen, Gerwert, Klaus

“…High-resolution protein ground-state structures of proton pumps and channels have revealed internal protein-bound water molecules. Their possible active…”
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The role of protein-bound water molecules in microbial rhodopsins by Gerwert, Klaus, Freier, Erik, Wolf, Steffen

“…Protein-bound internal water molecules are essential features of the structure and function of microbial rhodopsins. Besides structural stabilization, they act…”
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Functional waters in intraprotein proton transfer monitored by FTIR difference spectroscopy by Garczarek, Florian, Gerwert, Klaus

“…Much progress has been made in our understanding of water molecule reactions on surfaces, proton solvation in gas-phase water clusters and proton transfer…”
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Amyloid blood biomarker detects Alzheimer's disease by Nabers, Andreas, Perna, Laura, Lange, Julia, Mons, Ute, Schartner, Jonas, Güldenhaupt, Jörn, Saum, Kai‐Uwe, Janelidze, Shorena, Holleczek, Bernd, Rujescu, Dan, Hansson, Oskar, Gerwert, Klaus, Brenner, Hermann

“…Alzheimer's disease (AD) is currently incurable, but there is general agreement that a minimally invasive blood biomarker for screening in preclinical stages…”
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Early Formation of the Ion-Conducting Pore in Channelrhodopsin-2 by Kuhne, Jens, Eisenhauer, Kirstin, Ritter, Eglof, Hegemann, Peter, Gerwert, Klaus, Bartl, Franz

“…Channelrhodopsins (ChRs) are light‐gated ion channels that are widely used in optogenetics. They allow precise control of neuronal activity with light, but a…”
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Unifying photocycle model for light adaptation and temporal evolution of cation conductance in channelrhodopsin-2 by Kuhne, Jens, Vierock, Johannes, Tennigkeit, Stefan Alexander, Dreier, Max-Aylmer, Wietek, Jonas, Petersen, Dennis, Gavriljuk, Konstantin, El-Mashtoly, Samir F., Hegemann, Peter, Gerwert, Klaus

“…Although channelrhodopsin (ChR) is a widely applied light-activated ion channel, important properties such as light adaptation, photocurrent inactivation, and…”
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The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson’s disease brain as revealed by multicolor STED microscopy by Moors, Tim E., Maat, Christina A., Niedieker, Daniel, Mona, Daniel, Petersen, Dennis, Timmermans-Huisman, Evelien, Kole, Jeroen, El-Mashtoly, Samir F., Spycher, Liz, Zago, Wagner, Barbour, Robin, Mundigl, Olaf, Kaluza, Klaus, Huber, Sylwia, Hug, Melanie N., Kremer, Thomas, Ritter, Mirko, Dziadek, Sebastian, Geurts, Jeroen J. G., Gerwert, Klaus, Britschgi, Markus, van de Berg, Wilma D. J.

“…Various post-translationally modified (PTM) proteoforms of alpha-synuclein (aSyn)—including C-terminally truncated (CTT) and Serine 129 phosphorylated…”
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Aβ and tau structure-based biomarkers for a blood- and CSF-based two-step recruitment strategy to identify patients with dementia due to Alzheimer's disease by Nabers, Andreas, Hafermann, Henning, Wiltfang, Jens, Gerwert, Klaus

“…Alzheimer's disease (AD) diagnosis requires invasive CSF analysis or expensive brain imaging. Therefore, a minimal-invasive reliable and cost-effective blood…”
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The dynamics of the catalytic site in small GTPases, variations on a common motif by Kötting, Carsten, Gerwert, Klaus

“…Small GTPases control many cellular processes. Their catalytic downregulation by GTPase activating proteins (GAP) is essential. Many structural models of…”
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Raman Microspectroscopic Evidence for the Metabolism of a Tyrosine Kinase Inhibitor, Neratinib, in Cancer Cells by Aljakouch, Karim, Lechtonen, Tatjana, Yosef, Hesham K., Hammoud, Mohamad K., Alsaidi, Wissam, Kötting, Carsten, Mügge, Carolin, Kourist, Robert, El‐Mashtoly, Samir F., Gerwert, Klaus

“…Tyrosine kinase receptors are one of the main targets in cancer therapy. They play an essential role in the modulation of growth factor signaling and thereby…”
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Estimation of Protein–Ligand Unbinding Kinetics Using Non-Equilibrium Targeted Molecular Dynamics Simulations by Wolf, Steffen, Amaral, Marta, Lowinski, Maryse, Vallée, Francois, Musil, Djordje, Güldenhaupt, Jörn, Dreyer, Matthias K, Bomke, Jörg, Frech, Matthias, Schlitter, Jürgen, Gerwert, Klaus

“…We here report on nonequilibrium targeted molecular dynamics simulations as a tool for the estimation of protein–ligand unbinding kinetics. Correlating…”
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A Delocalized Proton-Binding Site within a Membrane Protein by Wolf, Steffen, Freier, Erik, Gerwert, Klaus

“…The role of protein-bound water molecules in protein function and catalysis is an emerging topic. Here, we studied the solvation of an excess proton by…”
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Label-free imaging of drug distribution and metabolism in colon cancer cells by Raman microscopy by El-Mashtoly, Samir F, Petersen, Dennis, Yosef, Hesham K, Mosig, Axel, Reinacher-Schick, Anke, Kötting, Carsten, Gerwert, Klaus

“…Targeted cancer therapies block cancer growth and spread using small molecules. Many molecular targets for an epidermal growth factor receptor (EGFR)…”
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Ras and GTPase-activating protein (GAP) drive GTP into a precatalytic state as revealed by combining FTIR and biomolecular simulations by Rudack, Till, Xia, Fei, Schlitter, Jürgen, Kötting, Carsten, Gerwert, Klaus

“…Members of the Ras superfamily regulate many cellular processes. They are down-regulated by a GTPase reaction in which GTP is cleaved into GDP and P ᵢ by…”
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Update on CSF Biomarkers in Parkinson's Disease by Kwon, Eun Hae, Tennagels, Sabrina, Gold, Ralf, Gerwert, Klaus, Beyer, Léon, Tönges, Lars

“…Progress in developing disease-modifying therapies in Parkinson's disease (PD) can only be achieved through reliable objective markers that help to identify…”
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Label-free, automated classification of microsatellite status in colorectal cancer by infrared imaging by Kallenbach-Thieltges, Angela, Großerueschkamp, Frederik, Jütte, Hendrik, Kuepper, Claus, Reinacher-Schick, Anke, Tannapfel, Andrea, Gerwert, Klaus

“…Challenging histopathological diagnostics in cancer include microsatellite instability-high (MSI-H) colorectal cancer (CRC), which occurs in 15% of early-stage…”
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Integrated Fourier Transform Infrared Imaging and Proteomics for Identification of a Candidate Histochemical Biomarker in Bladder Cancer by Witzke, Kathrin E., Großerueschkamp, Frederik, Jütte, Hendrik, Horn, Melanie, Roghmann, Florian, von Landenberg, Nicolas, Bracht, Thilo, Kallenbach-Thieltges, Angela, Käfferlein, Heiko, Brüning, Thomas, Schork, Karin, Eisenacher, Martin, Marcus, Katrin, Noldus, Joachim, Tannapfel, Andrea, Sitek, Barbara, Gerwert, Klaus

“…Histopathological differentiation between severe urocystitis with reactive urothelial atypia and carcinoma in situ (CIS) can be difficult, particularly after a…”
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Infrared spectral marker bands characterizing a transient water wire inside a hydrophobic membrane protein by Wolf, Steffen, Freier, Erik, Cui, Qiang, Gerwert, Klaus

“…Proton conduction along protein-bound "water wires" is an essential feature in membrane proteins. Here, we analyze in detail a transient water wire, which…”
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Lamprey Parapinopsin (“UVLamP”): a Bistable UV‐Sensitive Optogenetic Switch for Ultrafast Control of GPCR Pathways by Eickelbeck, Dennis, Rudack, Till, Tennigkeit, Stefan Alexander, Surdin, Tatjana, Karapinar, Raziye, Schwitalla, Jan‐Claudius, Mücher, Brix, Shulman, Maiia, Scherlo, Marvin, Althoff, Philipp, Mark, Melanie D., Gerwert, Klaus, Herlitze, Stefan

“…Optogenetics uses light‐sensitive proteins, so‐called optogenetic tools, for highly precise spatiotemporal control of cellular states and signals. The major…”
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