Search Results - "Gerwe, Gina S."

1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors by Klopfenstein, Sean R., Evdokimov, Artem G., Colson, Anny-Odile, Fairweather, Neil T., Neuman, Jeffrey J., Maier, Matthew B., Gray, Jeffrey L., Gerwe, Gina S., Stake, George E., Howard, Brian W., Farmer, Julie A., Pokross, Matthew E., Downs, Thomas R., Kasibhatla, Bhavani, Peters, Kevin G.

“…High-throughput screening of the P&GP corporate repository against several protein tyrosine phosphatases identified the sulfamic acid moiety as potential…”
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A nonspecific phosphotyrosine phosphatase inhibitor, bis(maltolato)oxovanadium(IV), improves glucose tolerance and prevents diabetes in Zucker diabetic fatty rats by Winter, Carol L, Lange, Jana S, Davis, Michael G, Gerwe, Gina S, Downs, Thomas R, Peters, Kevin G, Kasibhatla, Bhavani

“…The molecular basis of insulin resistance, a major risk factor for development of Type II diabetes, involves defective insulin signaling. Insulin-mediated…”
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Design and synthesis of potent, non-peptidic inhibitors of HPTPβ by Amarasinghe, Kande K.D., Evidokimov, Artem G., Xu, Kevin, Clark, Cynthia M., Maier, Matthew B., Srivastava, Anil, Colson, Anny-Odile, Gerwe, Gina S., Stake, George E., Howard, Brian W., Pokross, Matthew E., Gray, Jeffrey L., Peters, Kevin G.

“…The sulfamic acid phosphotyrosine mimetic was coupled with a previously known malonate template to obtain highly selective and potent inhibitors of HPTPβ…”
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Corrigendum to “Design and synthesis of potent, non-peptidic inhibitors of HPTPβ” [Bioorg. Med. Chem. Lett. 16 (2006) 4252–4256] by Amarasinghe, Kande K.D., Evdokimov, Artem G., Xu, Kevin, Clark, Cynthia M., Maier, Matthew B., Srivastava, Anil, Colson, Anny-Odile, Gerwe, Gina S., Stake, George E., Howard, Brian W., Pokross, Matthew E., Gray, Jeffrey L., Peters, Kevin G.

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Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta by Amarasinghe, Kande K D, Evdokimov, Artem G, Evidokimov, Artem G, Xu, Kevin, Clark, Cynthia M, Maier, Matthew B, Srivastava, Anil, Colson, Anny-Odile, Gerwe, Gina S, Stake, George E, Howard, Brian W, Pokross, Matthew E, Gray, Jeffrey L, Peters, Kevin G

“…The sulfamic acid phosphotyrosine mimetic was coupled with a previously known malonate template to obtain highly selective and potent inhibitors of HPTPbeta…”
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