Search Results - "Gervasio, Othon L"

TRPC1 binds to caveolin-3 and is regulated by Src kinase - role in Duchenne muscular dystrophy by Gervásio, Othon L, Whitehead, Nicholas P, Yeung, Ella W, Phillips, William D, Allen, David G

“…Transient receptor potential canonical 1 (TRPC1), a widely expressed calcium (Ca²⁺)-permeable channel, is potentially involved in the pathogenesis of Duchenne…”
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N-Acetylcysteine ameliorates skeletal muscle pathophysiology in mdx mice by Whitehead, Nicholas P., Pham, Catherine, Gervasio, Othon L., Allen, David G.

“…Duchenne muscular dystrophy (DMD) is a severe degenerative muscle disease caused by a mutation in the gene encoding dystrophin, a protein linking the…”
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Pathways of Ca²⁺ entry and cytoskeletal damage following eccentric contractions in mouse skeletal muscle by Zhang, Bao-Ting, Whitehead, Nicholas P, Gervasio, Othon L, Reardon, Trent F, Vale, Molly, Fatkin, Diane, Dietrich, Alexander, Yeung, Ella W, Allen, David G

“…Muscles that are stretched during contraction (eccentric contractions) show deficits in force production and a variety of structural changes, including loss of…”
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Activated Actin-Depolymerizing Factor/Cofilin Sequesters Phosphorylated Microtubule-Associated Protein during the Assembly of Alzheimer-Like Neuritic Cytoskeletal Striations by Whiteman, Ineka T, Gervasio, Othon L, Cullen, Karen M, Guillemin, Gilles J, Jeong, Erica V, Witting, Paul K, Antao, Shane T, Minamide, Laurie S, Bamburg, James R, Goldsbury, Claire

“…In Alzheimer's disease (AD), rod-like cofilin aggregates (cofilin-actin rods) and thread-like inclusions containing phosphorylated microtubule-associated…”
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Store-Operated Ca2+ Influx and Expression of TRPC Genes in Mouse Sinoatrial Node by Ju, Yue-Kun, Chu, Yi, Chaulet, Herve, Lai, Donna, Gervasio, Othon L, Graham, Robert M, Cannell, Mark B, Allen, David G

“…Store-operated Ca entry was investigated in isolated mouse sinoatrial nodes (SAN) dissected from right atria and loaded with Ca indicators. Incubation of the…”
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Developmental increase in the amount of rapsyn per acetylcholine receptor promotes postsynaptic receptor packing and stability by Gervásio, Othon L., Armson, Paul F., Phillips, William D.

“…Neuromuscular synaptic transmission depends upon tight packing of acetylcholine receptors (AChRs) into postsynaptic AChR aggregates, but not all postsynaptic…”
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Neural agrin increases postsynaptic ACh receptor packing by elevating rapsyn protein at the mouse neuromuscular synapse by Brockhausen, Jennifer, Cole, Rebecca N., Gervásio, Othon L., Ngo, Shyuan T., Noakes, Peter G., Phillips, William D.

“…Fluorescence resonance energy transfer (FRET) experiments at neuromuscular junctions in the mouse tibialis anterior muscle show that postsynaptic acetylcholine…”
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Cardiac and hepatic siderosis in myelodysplastic syndrome, thalassemia and diverse causes of transfusion‐dependent anemia: the TIMES study by Ho, P. Joy, Hiwase, Devendra, Ramakrishna, Raj, Viiala, Nicholas, Solterbeck, Ann, Traficante, Robert, Zor, Evren, Gervasio, Othon L., High, Laura M., Ross, David M., Bowden, Donald K.

“…Supplemental Digital Content is available in the text The significant morbidity and mortality associated with iron overload can be reduced by effective iron…”
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Increased ratio of rapsyn to ACh receptor stabilizes postsynaptic receptors at the mouse neuromuscular synapse by Gervásio, Othon L., Phillips, William D.

“…The metabolic turnover of nicotinic ACh receptors (AChR) at the neuromuscular synapse is regulated over a tenfold range by innervation status, muscle…”
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Anti-MuSK patient antibodies disrupt the mouse neuromuscular junction by Cole, Rebecca N., Reddel, Stephen W., Gervásio, Othon L., Phillips, William D.

“…Objective A subset of myasthenia gravis patients that are seronegative for anti‐acetylcholine receptor (anti‐AChR) antibodies are instead seropositive for…”
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Calcium and the damage pathways in muscular dystrophy by Allen, David G, Gervasio, Othon L, Yeung, Ella W, Whitehead, Nicholas P

“…Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disease caused by the absence of the cytoskeletal protein dystrophin. Experiments on the mdx…”
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Caveolae respond to cell stretch and contribute to stretch-induced signaling by Gervásio, Othon L, Phillips, William D, Cole, Louise, Allen, David G

“…Caveolae are invaginations of the plasma membrane that are formed by caveolins. Caveolar membranes are also enriched in cholesterol, glycosphingolipids and…”
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Cardiac iron load and function in transfused patients treated with deferasirox (the MILE study) by Ho, P. Joy, Tay, Lay, Teo, Juliana, Marlton, Paula, Grigg, Andrew, St Pierre, Tim, Brown, Greg, Badcock, Caro‐Anne, Traficante, Robert, Gervasio, Othon L., Bowden, Donald K.

“…Objectives To assess the effect of iron chelation therapy with deferasirox on cardiac iron and function in patients with transfusion‐dependent thalassemia…”
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Prevalence of Cardiac and Hepatic Siderosis in Australian Patients with Transfusion-Dependent Anemias or Non-Transfusion-Dependent Thalassemia, As Assessed By MRI (the TIMES study) by Ho, Phoebe Joy, Hiwase, Devendra, Ramakrishna, Raj, Viiala, Nicholas, Ross, David M, Zor, Evren, Gervasio, Othon L, Bowden, Donald

“…▪ Background: Iron overload in patients receiving red blood cell (RBC) transfusions for treatment of anemia and in patients with non-transfusion-dependent…”
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Efficacy and Safety of Nilotinib 300 Mg Twice Daily (BD) in Patients with CML in Chronic Phase (CML-CP) Who Are Intolerant to Prior BCR-ABL Tyrosine Kinase Inhibitors (TKIs): Results from the Randomized, Phase IIIb E.N.E.S.Tswift Study by Hiwase, Devendra K, Tan, Peter, D'Rozario, James, Taper, John, Powell, Anthony Richard, Irving, Ian, Wright, Matthew P.F., Branford, Susan, Yeung, David T., Anderson, Luke, Gervasio, Othon L, Hughes, Timothy P.

“…Background: Philadelphia chromosome-positive (Ph+) CML is a myeloproliferative disease characterized by the presence of the abnormal Ph+ in hematopoietic…”
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Collagen XVIII/endostatin is associated with the epithelial–mesenchymal transformation in the atrioventricular valves during cardiac development by Carvalhaes, Lorenza S., Gervásio, Othon L., Guatimosim, Cristina, Heljasvaara, Ritva, Sormunen, Raija, Pihlajaniemi, Taina, Kitten, Gregory T.

“…Type XVIII collagen is a multidomain protein that contains cleavable C‐terminal NC1 and endostatin fragments, which have been shown to either induce or inhibit…”
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Pathways of Ca 2+ entry and cytoskeletal damage following eccentric contractions in mouse skeletal muscle by Zhang, Bao-Ting, Whitehead, Nicholas P., Gervasio, Othon L., Reardon, Trent F., Vale, Molly, Fatkin, Diane, Dietrich, Alexander, Yeung, Ella W., Allen, David G.

“…Muscles that are stretched during contraction (eccentric contractions) show deficits in force production and a variety of structural changes, including loss of…”
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Pathways of Ca^sup 2+^ entry and cytoskeletal damage following eccentric contractions in mouse skeletal muscle by Zhang, Bao-Ting, Whitehead, Nicholas P, Gervasio, Othon L, Reardon, Trent F, Vale, Molly, Fatkin, Diane, Dietrich, Alexander, Yeung, Ella W, Allen, David G

“…Muscles that are stretched during contraction (eccentric contractions) show deficits in force production and a variety of structural changes, including loss of…”
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A Study of Magnetic Resonance Imaging Assessment of Cardiac and Liver Iron Load in Patients with Haemoglobinopathies, Myelodysplastic Syndromes or Other Anaemias Treated with Deferasirox (the MILE study CICL670AAU01) – Results of An Interim Analysis At a Planned Sample Size Reassessment by Ho, P. Joy, Tay, Lay, Teo, Juliana, Marlton, Paula, Grigg, Andrew, St. Pierre, Tim, Brown, Greg, Gervasio, Othon L, Bowden, Donald K

“…Abstract 3181 Cardiac failure is the leading cause of death in patients with thalassaemia major. However, the introduction of new monitoring techniques, such…”
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Pathways of Ca2+ entry and cytoskeletal damage following eccentric contractions in mouse skeletal muscle by ZHANG, Bao-Ting, WHITEHEAD, Nicholas P, GERVASIO, Othon L, REARDON, Trent F, VALE, Molly, FATKIN, Diane, DIETRICH, Alexander, YEUNG, Ella W, ALLEN, David G

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