Search Results - "Geruntho, Jonathan J."

Tunable pH-Sensitive Linker for Controlled Release by Choy, Cindy J, Geruntho, Jonathan J, Davis, Austen L, Berkman, Clifford E

“…We have developed a novel pH-sensitive linker based on a phosphoramidate scaffold that can be tuned to release amine-containing drug molecules at various pH…”
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Silica nanostructured platform for affinity capture of tumor-derived exosomes by Ziaei, Parissa, Geruntho, Jonathan J., Marin-Flores, Oscar G., Berkman, Clifford E., Grant Norton, M.

“…Early diagnosis of prostate cancer and evaluation of appropriate treatment options requires development of effective and high-throughput selective capture…”
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Second-Generation Tunable pH-Sensitive Phosphoramidate-Based Linkers for Controlled Release by Choy, Cindy J., Ley, Corinne R., Davis, Austen L., Backer, Brian S., Geruntho, Jonathan J., Clowers, Brian H., Berkman, Clifford E.

“…We developed a second generation of tunable pH-sensitive linkers based on our phosphoramidate scaffold to release amine-containing drugs under acidic…”
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Preclinical Dosimetry, Imaging, and Targeted Radionuclide Therapy Studies of Lu-177-Labeled Albumin-Binding, PSMA-Targeted CTT1403 by Ling, Xiaoxi, Latoche, Joseph D., Choy, Cindy J., Kurland, Brenda F., Laymon, Charles M., Wu, Yijen, Salamacha, Nathan, Shen, Ding, Geruntho, Jonathan J., Rigatti, Lora H., Windish, Hillarie P., Langton-Webster, Beatrice, Berkman, Clifford E., Anderson, Carolyn J.

“…Purpose Prostate-specific membrane antigen (PSMA) continues to be the hallmark biomarker for prostate cancer as it is expressed on nearly all prostatic tumors…”
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Structure-Activity Relationship of (18)F-Labeled Phosphoramidate Peptidomimetic Prostate-Specific Membrane Antigen (PSMA)-Targeted Inhibitor Analogues for PET Imaging of Prostate Cancer by Dannoon, Shorouk, Ganguly, Tanushree, Cahaya, Hendry, Geruntho, Jonathan J, Galliher, Matthew S, Beyer, Sophia K, Choy, Cindy J, Hopkins, Mark R, Regan, Melanie, Blecha, Joseph E, Skultetyova, Lubica, Drake, Christopher R, Jivan, Salma, Barinka, Cyril, Jones, Ella F, Berkman, Clifford E, VanBrocklin, Henry F

“…A series of phosphoramidate-based prostate specific membrane antigen (PSMA) inhibitors of increasing lipophilicity were synthesized (4, 5, and 6), and their…”
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Conformational Change with Steric Interactions Affects the Inner Sphere Component of Concerted Proton–Electron Transfer in a Pyridyl-Appended Radical Cation System by Welker, Evan A, Tiley, Brittney L, Sasaran, Crina M, Zuchero, Matthew A, Tong, Wing-Sze, Vettleson, Melissa J, Richards, Robert A, Geruntho, Jonathan J, Stoll, Stefan, Wolbach, Jeffrey P, Rhile, Ian J

“…Proton-coupled electron transfer (PCET) model systems combine one-electron oxidants and bases to generate net hydrogen atom acceptors. We have generated two…”
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Structure–Activity Relationship of 18F‑Labeled Phosphoramidate Peptidomimetic Prostate-Specific Membrane Antigen (PSMA)-Targeted Inhibitor Analogues for PET Imaging of Prostate Cancer by Dannoon, Shorouk, Ganguly, Tanushree, Cahaya, Hendry, Geruntho, Jonathan J, Galliher, Matthew S, Beyer, Sophia K, Choy, Cindy J, Hopkins, Mark R, Regan, Melanie, Blecha, Joseph E, Skultetyova, Lubica, Drake, Christopher R, Jivan, Salma, Barinka, Cyril, Jones, Ella F, Berkman, Clifford E, VanBrocklin, Henry F

“…A series of phosphoramidate-based prostate specific membrane antigen (PSMA) inhibitors of increasing lipophilicity were synthesized (4, 5, and 6), and their…”
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177 Lu-Labeled Phosphoramidate-Based PSMA Inhibitors: The Effect of an Albumin Binder on Biodistribution and Therapeutic Efficacy in Prostate Tumor-Bearing Mice by Choy, Cindy J, Ling, Xiaoxi, Geruntho, Jonathan J, Beyer, Sophia K, Latoche, Joseph D, Langton-Webster, Beatrice, Anderson, Carolyn J, Berkman, Clifford E

“…Prostate-specific membrane antigen (PSMA) continues to be an active biomarker for small-molecule PSMA-targeted imaging and therapeutic agents for prostate…”
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Biochemical characterization of prostate-specific membrane antigen from canine prostate carcinoma cells by Wu, Lisa Y., Johnson, Jacqueline M., Simmons, Jessica K., Mendes, Desiree E., Geruntho, Jonathan J., Liu, Tiancheng, Dirksen, Wessel P., Rosol, Thomas J., Davis, William C., Berkman, Clifford E.

“…BACKGROUND Prostate‐specific membrane antigen (PSMA) remains an important target for diagnostic and therapeutic application for human prostate cancer. Model…”
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177Lu-Labeled Phosphoramidate-Based PSMA Inhibitors: The Effect of an Albumin Binder on Biodistribution and Therapeutic Efficacy in Prostate Tumor-Bearing Mice by Choy, Cindy J., Ling, Xiaoxi, Geruntho, Jonathan J., Beyer, Sophia K., Latoche, Joseph D., Langton-Webster, Beatrice, Anderson, Carolyn J., Berkman, Clifford E.

“…Prostate-specific membrane antigen (PSMA) continues to be an active biomarker for small-molecule PSMA-targeted imaging and therapeutic agents for prostate…”
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Dose optimization of ^sup 177^Lu-labeled phosphoramidate-based PSMA inhibitor with an albumin-binding motif (CTT1403) and therapeutic efficacy comparison to ^sup 177^Lu-PSMA-617 by Ling, Xiaoxi, Choy, Cindy J, Latoche, Joseph D, Geruntho, Jonathan J, Langton-Webster, Beatrice, Berkman, Clifford E, Anderson, Carolyn J

“…Prostate-specific membrane antigen (PSMA) is a potential biomarker for prostate cancer treatment and imaging. It has restricted expression on prostate cancer…”
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Second-Generation Tunable pH-Sensitive Phosphoramidate-Based Linkers for Controlled by Choy, Cindy J, Ley, Corinne R, Davis, Austen L, Backer, Brian S, Geruntho, Jonathan J, Clowers, Brian H, Berkman, Clifford E

“…We developed a second generation of tunable pH-sensitive linkers based on our phosphoramidate scaffold to release amine-containing drugs under acidic…”
Get full text

Structure–Activity Relationship of 18 F-Labeled Phosphoramidate Peptidomimetic Prostate-Specific Membrane Antigen (PSMA)-Targeted Inhibitor Analogues for PET Imaging of Prostate Cancer by Dannoon, Shorouk, Ganguly, Tanushree, Cahaya, Hendry, Geruntho, Jonathan J., Galliher, Matthew S., Beyer, Sophia K., Choy, Cindy J., Hopkins, Mark R., Regan, Melanie, Blecha, Joseph E., Skultetyova, Lubica, Drake, Christopher R., Jivan, Salma, Barinka, Cyril, Jones, Ella F., Berkman, Clifford E., VanBrocklin, Henry F.

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Biochemical characterization of prostate-specific membrane antigen from canine prostate carcinoma cells: PSMA Expression in Canine Prostate Cancer by Wu, Lisa Y., Johnson, Jacqueline M., Simmons, Jessica K., Mendes, Desiree E., Geruntho, Jonathan J., Liu, Tiancheng, Dirksen, Wessel P., Rosol, Thomas J., Davis, William C., Berkman, Clifford E.

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